Building Blocks

<p>Versatile small molecule scaffold</p>

<p>4-Amino-4'-hydroxybenzophenone is a benzophenone with a hydroxyl group in the ortho position. It has absorption spectra that are similar to those of benzene, but it is less soluble in solvents and more soluble in water. The molecule has two possible conformations, both of which have an equilibrium constant (K) of 10. The two conformations can interconvert by rotation about the C=C bond, which is referred to as torsion. This conformational change in the molecule alters its light absorption properties.</p>

<p>4-Methoxyisobenzofuran-1,3-dione is a natural product that belongs to the group of hydroxybenzoic acids. It is obtained by the hydrogenation of 3-nitrophthalic anhydride and 3-hydroxyphthalic anhydride, which are obtained from anacardic acid. 4-Methoxyisobenzofuran-1,3-dione has been used as an intermediate for antibiotics and synthetic dyestuffs. The chloride salt of this compound has been used as a reagent in organic synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Phenylcycloheptan-1-one is a chemical used in organic synthesis. It has been shown to undergo decarbonylation and dimerization reactions, as well as rearrangements of the carbon-carbon double bond. These reactions are used to synthesize a wide variety of other molecules. The efficiency of 2-phenylcycloheptan-1-one depends on the type and amount of reagents used in the process, as well as on the structure of the molecule being synthesized. 2-Phenylcycloheptan-1-one is often used as a sensitizer for photochemical reactions due to its ability to absorb ultraviolet light.</p>

<p>2-(2-Amino-2-phenylethoxy)-1,3-dimethylbenzene is a molecule that binds to the sodium channel of nerve cells and blocks the flow of ions. It prevents the nerve cell from transmitting its signal. This drug has been shown to be effective in animal models for muscle spasms, but it is not used clinically because it can cause paralysis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

2-(1H-1,2,3-Benzotriazol-1-yloxy)acetic acid is a ligand that has been used to study molecular orbitals and the theory of diffraction. It is also luminescent and can be used for elemental analysis. The crystal system of 2-(1H-1,2,3-Benzotriazol-1-yloxy)acetic acid is trigonal pyramidal with a space group P212121. This molecule has an isomorphous substitution in the coordination sphere with the metal ion. The functional theory was applied to this molecule to elucidate its absorption properties. When this ligand absorbs light, it can transfer energy to other molecules through resonance, which may lead to changes in their electronic structure.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-[4-(4H-1,2,4-Triazol-4-yl)phenyl]acetic acid (DSC) is a compound that has been shown to have anti-cancer properties. It was found to be effective against breast cancer cells in vitro and in vivo. The cytotoxic effect of DSC on cancer cells may be due to its ability to bind to the membrane phospholipid bilayer and interfere with the cell's ability to regulate ion fluxes. This can lead to increased intracellular calcium levels and subsequent activation of proteases, which are important for the proliferation of cancer cells. 2-[4-(4H-1,2,4-Triazol-4-yl)phenyl]acetic acid has also been found to inhibit protein synthesis in cancer cells. These results show that 2-[4-(4H-1,2,4-Triazol-4-yl)phenyl]acetic acid may</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>3-Methylnaphthalene-2-carboxylic acid is a dicarboxylic acid that can be found in the environment. It has been isolated from Australian soil samples and is produced by some bacterial strains. 3-Methylnaphthalene-2-carboxylic acid has antimicrobial activity, which may be due to its ability to inhibit microbial growth by inhibiting protein synthesis.</p>

<p>1-(Aminomethyl)naphthalene hydrochloride (1-AMN) is an organocatalytic oxidant that is used to oxidize quaternary ammonium salts and quinazolinones. 1-AMN is a white crystalline solid that can be stored at room temperature. It has been shown to have the ability to react with anisidine, amines, and alcohols to produce aniline, nitrosobenzene, and hydroxylamine, respectively. This product also has a functional group which is capable of reacting with chlorides or diazonium ions. The use of this product in biochemistry has been shown in the immobilization of biomolecules such as DNA and RNA.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Quinolin-2-yl)propanoic acid is a quinoline derivative that is used to treat inflammatory diseases. It is thought to have an anti-inflammatory effect by inhibiting the production of the fatty acid arachidonic acid, which is then converted into prostaglandins and leukotrienes. 3-(Quinolin-2-yl)propanoic acid inhibits cellular signaling by binding to specific protein receptors. This drug binds to the fatty acids in cell membranes, which leads to the inhibition of cellular growth factor signal transduction and signal detection. Research has shown that 3-(quinolin-2-yl)propanoic acid has a toxic effect on humans, as well as other animals, including rats and mice. The animal studies showed that this drug inhibited the growth of cancer cells in human colon tumors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>NSC 185058 is a potential cancer therapy that inhibits protein synthesis in the cell. It prevents cells from growing and dividing by inhibiting their ability to synthesize proteins. NSC 185058 also induces apoptotic cell death, which is programmed cell death that occurs as a result of genetic or environmental stress. When cells undergo apoptosis, they are able to destroy themselves without releasing harmful substances into the surrounding area. NSC 185058 has been shown to induce autophagy and autophagy-related proteins in animal models. Autophagy is a process by which cells break down dysfunctional components to recycle nutrients and energy for future use. NSC 185058 has also been shown to inhibit tumor growth in mice with malignant brain tumors when used in combination with other therapies such as radiation and chemotherapy.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,4-Dibromo-2,5-dimethylthiophene is a diphosphinoethane that has been used as a catalyst for the thermal and photochemical activation of methyl groups. It has been shown to have a high reactivity with hexane and form fluorescent polymer films. 3,4-Dibromo-2,5-dimethylthiophene is structurally similar to other diphosphinoethanes that are used in phosphine devices and polymer films. The crystal structure of 3,4-dibromo-2,5-dimethylthiophene has been determined using X-ray crystallography. In this study it was found that the molecule can exist in two different structural isomers.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Ethylthiazol-2-amine is a chemical that yields, on hydrolysis, a mixture of 5-ethylthiazole and 2-aminoethanol. It can be prepared by the reaction of ethyl mercaptan with carbon tetrachloride in the presence of potassium hydroxide. The spectral data for this compound are given in Table 1. The reaction time for this synthesis is about 25 minutes and it is operational at temperatures from 0 to 100°C. This compound reacts with tetracycline, an antibiotic, to yield a yellow solid. It also reacts with solvents such as acetonitrile and amines to give a white precipitate.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Phenyl N-(1,3-thiazol-2-yl)carbamate is a crystal structure stabilizer. It is an oriented, two-dimensional molecule that contains two phenyl rings (-C6H5) connected to each other by a single bond and one thiazole ring (-N=C=S). The orientation of the molecule in space is stabilized by a dihedral angle of 60° between the two phenyl rings. This orientation causes the phenyl rings to point in opposite directions and prevents them from rotating around their axis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>tert-Butyl 2-methyl-3-oxobutanoate is a metabolite of tert-butyl acetate, which is an organic compound that has been used for the production of synthetic rubber and other chemicals. The biosynthesis of tert-butyl 2-methyl-3-oxobutanoate is dependent on the availability of a ketoaldehyde precursor. When tert-butyl acetate is incubated with aspergillus niger, the desired product can be obtained in high yield. Tertiary butyl 2 methyl 3 oxobutanoate can also be synthesized by deuteration of tertiary butyl alcohol with deuterium gas. The product can then be purified using gas chromatography/mass spectroscopy (GC/MS) and identified using nuclear magnetic resonance (NMR) analysis.</p>

<p>Ethyl ±-Bromo-²-phenylpropionate is a thiomorpholine that is used in organic reactions. It has been found to be an effective catalyst for the epoxidation of alkenes, as well as for the acylation of alcohols and amines.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(2-Bromoacetyl)-1H-isochromen-1-one is a heterocyclic compound that can be prepared using the following preparative method.</p>

<p>Versatile small molecule scaffold</p>

<p>1,4,5,6,7,7a-Hexahydro-inden-2-one is a cycloaddition product of two 1,4-dihydrobenzenes. It has been shown to undergo the pauson-khand reaction with diazomethane to produce a cyclopropane ring.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Ethynyl-1-benzofuran is a ligand in organic chemistry that can react with an oxidant to form terminal alkynes. It has been shown to undergo hydrofunctionalization and stereocontrol, which are two of the most commonly studied reactions in organic chemistry. This compound is also used as a precursor for benzofurans, which are important organic compounds that have been studied extensively due to their structural diversity. 2-Ethynyl-1-benzofuran is synthesized from azides and aldehydes or triazoles, which can be obtained through advances in organic chemistry.</p>

<p>Sodium propane-1-sulfinate is a carbonyl group that introduces an amyloid protein with a methyl ketone and hydroxyl group. The presence of the methyl ketone isomers can be explained by the cyclic structure, which consists of six carbons. This functional group has been shown to inhibit the activity of crth2, which is part of a heterocycle. Sodium propane-1-sulfinate also inhibits retinoic acid c1-6 alkylase, which is a functional group found in the human body. The introduction of this functional group may have an inhibitory effect on metabolism.</p>

<p>(5-Phenylfuran-2-yl)methanamine is a drug that has been shown to be effective in treating neurodegenerative diseases and cancer. It is a member of the sirtuin family, which are enzymes that regulate gene expression. The drug inhibits SIRT2 and other deacetylases, which may lead to the development of new treatment strategies for neurodegenerative diseases and cancer. (5-Phenylfuran-2-yl)methanamine has high water solubility, which allows it to penetrate through the blood brain barrier more effectively than hydrophobic drugs. This property also makes it possible to administer lower doses of the drug, thereby reducing side effects on healthy cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-N-methylbenzylamine is a nitro compound that has been shown to have antimycobacterial activity. It belongs to the class of aliphatic hydrocarbons, which are functional groups consisting of a chain of carbon atoms with hydrogen atoms attached to some of the carbons. The molecular modeling found that 3-methyl-N-methylbenzylamine binds to the active site of mycobacterial enoyl reductase and inhibits its activity. This leads to a decrease in cellular energy metabolism, which can lead to cell death. 3-Methyl-N-methylbenzylamine also has an amine group, which is an organic acid that contains nitrogen and hydrogen. These molecules are important for piperazine synthesis and may be responsible for the antimycobacterial properties of 3-methyl-N-methylbenzylamine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenylbutanehydrazide is a nitro, carbonyl group and hydrogen bond donor. It has an interaction with the benzyl group of 4-phenylbutanoylhydrazide through hydrogen bonds. The conformation of 4-phenylbutanehydrazide is agonistic and its secondary structure is mainly determined by the carbonyl group. The carbonyl group interacts with the hydrazide nucleus through a hydrogen bond, while its acylhomoserine residue interacts with the carbonyl group through a thiocarbamate interaction. This compound may be classified as an agonist or antagonist depending on the receptor it binds to.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Cyclopentyl-N-propylamine is a functional compound that belongs to the class of organic compounds. It is used as an intermediate in the synthesis of other drugs and pharmaceuticals. This compound has been shown to have a high reactivity, which makes it useful in polymerization and polymerization initiator applications. N-Cyclopentyl-N-propylamine has been shown to be reactive with polarizers, alkylthio groups, and trifluoromethyl groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Bis(3-methoxyphenyl)methanone is a palladium catalyst that selectively activates olefins. It has been shown to be useful in the synthesis of dihydrobenzofurans and oxonium derivatives, which are used as pharmaceuticals. This compound also catalyzes the transformation of various functional groups, such as diazo, alkenes, and intramolecular aldol condensation. Bis(3-methoxyphenyl)methanone is used as a catalyst for the production of dibenzofuran compounds with high selectivity. The diastereoselectivity of this compound is due to its ability to activate substrates with electron-donating groups at positions ortho to the phenyl group.</p>

<p>Versatile small molecule scaffold</p>

<p>3,3-Dimethyl-1-(methylsulfanyl)butan-2-one is an enolate that is used as a pesticide. It is typically applied to the soil or sprayed on plants. It can be modified to increase its insecticidal activity by adding other chemicals such as carbaryl, acetonitrile, or hydroxymethylphenyl. 3,3-Dimethyl-1-(methylsulfanyl)butan-2-one is metabolized by hydrolysis and methylcarbamates are formed. The sulfide group in the molecule reacts with oxygen to form sulfoxides and carbofuran, which are toxic to mammals and birds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>4-Ethylamino-1-butanol is an alkanolamine that interacts with receptors in the body. It has a hydroxyl group and is a molecule that contains functionalities. It interacts with other molecules, such as corticotropin-releasing hormone (CRH). 4-Ethylamino-1-butanol binds to CRH and prevents it from binding to its receptor, which decreases the release of corticotropin. This compound has been used as a positron emission tomography (PET) radiotracer for imaging the insulin receptor in living tissue. The chemical can be systematically introduced into tissues and organs, including the brain, where it accumulates due to its hydrophilic nature. 4-Ethylamino-1-butanol also has oxygenated groups that are suitable for PET imaging using 18F radiolabeling.</p>

<p>Versatile small molecule scaffold</p>

5-Nitro-1,2,3,4-tetrahydroquinoline is an amine that is used in the synthesis of other chemicals. It is selective for transfer reactions because it can transfer to sulfate. The reaction selectivity is determined by the module and the reaction solution. The efficiency of the carbenium ion can be increased by adjusting the pH to make it more acidic. 5-Nitro-1,2,3,4-tetrahydroquinoline has a high yield and can be synthesized with a high degree of purity by using ammonium sulfate as a transfer agent in a neutral solution.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>5-Dichloro-2-nitrophenol is a chemical that is used as an immunomodulator, pesticide, or herbicide. It is activated by the body to form a reactive intermediate that can bind to DNA and create mutations. 5-Dichloro-2-nitrophenol has been shown to cause oxidative damage in cell cultures and other tissues, such as proximal tubules of the kidney. It also produces malondialdehyde oxidation products which are known to be cytotoxic. In addition, preincubation with 5-Dichloro-2-nitrophenol increases the sensitivity of cells to other oxidative stressors such as peroxides and hydrogen peroxide.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>