Building Blocks

1-Azido-4-ethylbenzene is a chemical compound that is synthesized from 1-azido-2,4-dibromobenzene and an alkylating agent. It reacts with triflates to produce the corresponding aziridines. The synthesis of 1-azido-4-ethylbenzene can be achieved by using photoreduction or cross coupling reactions. This compound is used in the synthesis of diarylamines and aziridinium salts.
1-Azido-4-ethylbenzene can be synthesized from 1,2,3,4,5,6-(dibromomethyl)benzene and an alkylating agent (e.g., ethyl bromide). It reacts with triflates to produce the corresponding aziridines. The synthesis of 1-azido-4-ethylbenzene can also be achieved by using photore

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloroquinolin-3-ol is an orally active, organic solvent-free, synthetic drug that is a basic compound. It has been shown to have anti-inflammatory properties and can be used for the treatment of inflammatory diseases such as rheumatoid arthritis. The drug has also been shown to be effective against autoimmune diseases such as type 1 diabetes mellitus. 2-Chloroquinolin-3-ol is an analogue of quinolinic acid, which is found in plants and animals. 2CQOL binds to chloride channels on the surface of cells, which prevents the influx of chloride ions into the cell and leads to cytotoxicity.

Versatile small molecule scaffold

6-Ethynyl-2-methylquinoline is a natural product that can be synthesized by the photochemical reaction of arylacetylenes with styrenes. The synthesis proceeds via an anti-markovnikov cyclization to yield the desired product. This process requires two steps and produces two products, one being 6-ethynyl-2-methylquinoline. Protodeboronation then takes place on the methyl group to yield 6-ethynylquinoline. Mechanistic studies have shown that this reaction is catalytic, with regioselectivity controlled by the protodeboronation step.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1,2,3,4-Tetrahydroquinolin-5-amine (1,2,3,4-THQ) is a hydrazine derivative that has been used in organic synthesis as a reagent for the reductive amination of amines. It is also used as a precursor for the synthesis of other heteroaromatic compounds. The 1,2,3,4-THQ can be prepared by condensation of aniline with nitroethane and phenylenediamine in the presence of Raney nickel. Analogous reactions have been reported using benzylamine derivatives.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold