Building Blocks

Versatile small molecule scaffold

N-Benzyl(cyclopropyl)methanamine is a phenanthrene derivative that is synthesized by the reaction of benzylic methylene with methanol. This compound can be hydrolyzed to benzoic acid and cyclopropanol. N-Benzyl(cyclopropyl)methanamine has been used as an electrode material for organic electrochemical cells as it has high electron transfer and overpotential, making this compound more suitable than other materials such as benzylic or alkyl groups. The synthesis of esters from N-benzyl(cyclopropyl)methanamine can be achieved through the use of acetals.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Benzyloxane-2,6-dione is a methyl ester that has been optimized for pharmacokinetic properties. It is an amide with a catalytic activity and has been shown to bind to phospholipids. This compound has been screened in high-throughput screening tests and has been validated by binding to brain tissue. The pharmacological effects of 4-Benzyloxane-2,6-dione have not yet been elucidated but it is believed that the compound may be able to inhibit the production of beta amyloid peptides in the brain, which are thought to play a role in Alzheimer's disease.

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 5-iodopyridine-2-carboxylate is an amino acid analog that specifically binds to lysine residues. This compound inhibits the incorporation of lysine into proteins, which may be important for the study of protein synthesis. Methyl 5-iodopyridine-2-carboxylate has been shown to react with aromatic amino acids and form amidines that are stable in aqueous solution. It can also react with tryptic peptides to yield model compounds.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1H-Indene-2-carboxylic acid is a 6-carboxylic acid that has been found to inhibit the growth of cancer cells in vitro. It has been shown to competitively inhibit the activation of peroxisome proliferator-activated receptor gamma (PPARγ), which is involved in controlling cell growth and differentiation. 1H-Indene-2-carboxylic acid also inhibits the activity of cytochrome P450 and induces apoptotic cell death, which may be due to its ability to activate caspase 3. This drug was also shown to increase levels of growth factors by upregulating expression of insulin like growth factor II (IGFII).

1-((Pyridin-2-yl)methyl)piperidin-4-one is an organic compound that can be synthesized from piperidine and malonic acid. It is an antipsychotic agent that binds to the dopamine D4 receptor, which may be responsible for its antiangiogenic properties. 1-(Pyridin-2-yl)methyl)piperidin-4-one has been shown to inhibit the growth of human umbilical vein endothelial cells in culture and to block the formation of new blood vessels, as well as to reduce the volume of existing blood vessels. This drug also has a high yield in crystallization and is easy to synthesize from commercially available starting materials.