Building Blocks

Chroman-6-carbaldehyde is a chemical compound that has been shown to have antidiabetic and antifungal activity. It is synthesized by reductive amination of chroman-6-carboxylic acid with an amine (e.g., piperazine) in the presence of sodium cyanoborohydride. Chroman-6-carbaldehyde inhibits lipase activity, which can decrease the blood glucose level in diabetic patients, and also has antibacterial properties. This compound is one of the active compounds found in a strain of fungus Penicillium sp., which was isolated from soil samples collected in the city of Kolkata, India. Chroman-6-carbaldehyde is fluorescent and can be detected using fluorescence spectroscopy and high performance liquid chromatography (HPLC).

3-Methyl-5-nitro-1H-indole is a potent inhibitor of rifampicin, which is an antibiotic used to treat tuberculosis. 3-Methyl-5-nitro-1H-indole inhibits the growth of bacteria by binding to the 50S ribosomal subunit. It does not show any bactericidal activity in vitro and has been found to be ineffective in mice with chronic infections. 3-Methyl-5-nitro-1H-indole binds to the 50S ribosomal subunit and prevents the formation of antibiotic–ribosome complexes that are needed for bacterial protein synthesis. This drug also has pharmacokinetic properties that have been optimized for oral administration in humans. 3methyl 5 nitro 1H indole targets enzymes involved in DNA replication and transcription, such as bacterial gyrase, dna topoisomerase, and RNA polymerase.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,5-Dioxo-2,5-dihydro-1H-pyrrole is a compound that belongs to the group of heterocyclic compounds. It is an amide derivative of 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1yl)phenylacetic acid. 2,5-Dioxo-2,5-dihydro-1H pyrrole has been shown to have high radiation resistance and can be used for the production of polyimide film and plastics. This compound also has thermogravimetric properties that make it suitable for use as a heat transfer fluid in industrial furnaces. 2,5 Dioxo -2,5 dihydro -1H pyrrole has nitrogen atoms at both ends of the molecule that are reactive with amino groups on other molecules. The terminal amino groups on 2, 5 dioxo

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold