Building Blocks

7-Benzyl-2,6-dichloro-7H-purine is a reagent that is used in the synthesis of adenine and other purines. It can be synthesized by coupling 3-methylxanthine with aminoacids and organometallic reagents. This chemical can also be used to selectively synthesize 6-benzyladenine, which is an important precursor to pharmaceuticals. The 7-benzyl group on this chemical has been shown to act as a positional group in the catalytic hydrogenation of amines. This selective hydrogenation process has been found to be regioselective for cycloalkyl amines.

Versatile small molecule scaffold

Rhosin hydrochloride is a cardiac glycoside derived from the plant Rhosinus peregrinus. It has been shown to have a regulatory effect on cardiac hypertrophy, and has been used in animal experiments to treat cancer. Rhosin hydrochloride is also known to inhibit cell factor and regulatory adhesions, which are proteins that aid in the binding of cells to other cells or tissue. It has been shown to be effective at inhibiting the uptake of calcium ions by rat cardiomyocytes. These properties make rhosin hydrochloride an attractive target for future research into cardiovascular disease treatment.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methyl-1-phenylbutane-1,3-dione is a chemical intermediate that belongs to the group of alkyl bromides. It is used as an herbicide and a pesticide, and can be reduced to 2-methyl-2-(4'-bromophenyl)pentanal by reductive cleavage with chlorine. The reduction of 2-methyl-1-phenylbutane-1,3-dione by hydrogen gas leads to the diastereoisomers 2-(4'-bromophenyl)-2-(2'-methylpropionyl)pentanal and 3-(4'-bromophenyl)-2-(2'-methylpropionyl)pentanal. The former is a chiral molecule that can be used as a medicine for high blood pressure, while the latter has been shown to be effective against microbial strains such as Escherichia coli and Candida albicans.

Versatile small molecule scaffold

Versatile small molecule scaffold

Dichloropyridazine-3,6-diol is a furan derivative that has been shown to act as an inhibitor of the oxidative deamination of pyridine. It is also a nucleophilic reagent with a chlorine atom and two hydroxylamine groups in its structure. The carbonyl oxygen atom and the cyclic carbonyl group are both susceptible to oxidation and can be used to form chlorides. Dichloropyridazine-3,6-diol is resistant to acid chlorides such as thionyl chloride or phosphoric acid. This compound undergoes dehydration reactions with carboxylic acids and chlorides, yielding the corresponding carboxylate or chloride.

2-Methyl-1,2,3,4-tetrahydroquinoxaline is an enantioselective antioxidant that has been shown to have a chiral conformation. It has also been found to be a catalyst in the reductive elimination of hydrochloric acid. This compound can be hydrogenated by catalytic hydrogenation and this reaction produces tetralin as a by-product. 2-Methyl-1,2,3,4-tetrahydroquinoxaline is used in research because it contains a methyl group and amines that are important for biological functions.

3,5-Diamino-4-methylbenzoic acid is a chemical compound with the formula C6H3N3O2. It is an organic nitrite that reacts readily with nucleophiles such as alcohols, phenols, and amines to form the corresponding N-substituted benzoic acid. The reaction proceeds via a two step process in which 3,5-diamino-4-methylbenzoic acid first reacts with sodium nitrite to produce 3,5-diamino-4-nitrobenzoic acid followed by hydrolysis of this intermediate to form the desired product. Nitrite salts are used in the food industry as preservatives and antimicrobials. They can be applied as a gas or dissolved in water. Nitrite salts are also used for wastewater treatment and for environmental remediation.

Versatile small molecule scaffold

Versatile small molecule scaffold