Building Blocks

Rac-2,2'-Methylenebis(4-oxatricyclo[5.2.1.0,2,6]dec-8-ene)-3,5-dione is a polyvalent anhydride that has been used as a crosslinking agent in epoxy resin systems and as a viscosity modifier in polymerizable systems. It is also used as an additive to improve the properties of powder coatings and to produce polycarboxylic acid dispersions for use in alkyd resins and oil field chemical additives. The material is supplied as a colloidal suspension in water with a particle size of less than 1 micron. Racemic 2,2'-Methylenebis(4-oxatricyclo[5.2.1.0,2,6]dec-8-ene)-3,5-dione (rac-(1R,2S,6R,7S)-

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Mabuprofen is a nonsteroidal anti-inflammatory drug that belongs to the class of NSAIDs. It is used to treat pain, inflammation, and stiffness caused by osteoarthritis, rheumatoid arthritis, and other joint diseases. Mabuprofen is a prodrug that has been shown to inhibit the production of prostaglandins in the brain and spinal cord. This inhibition leads to an increase in cyclic adenosine monophosphate (cAMP) levels which can then reduce the production of proteins in cells. This can have anti-inflammatory effects that are beneficial for people with inflammatory bowel disease or hyperproliferative diseases such as cancer. Mabuprofen has also been shown to decrease the levels of soybean trypsin inhibitor in rats with bowel disease. The mechanism for this activity may be due to its ability to act as a substrate molecule for enzyme reactions, such as soybean trypsin inhibitors.

Versatile small molecule scaffold

Tetrahydroquinolin-2(1H)-one is a hydrobromide that has been found in the environment as an environmental pollutant. Tetrahydroquinolin-2(1H)-one is used to synthesize amides and has been studied by single-crystal x-ray diffraction. The molecule is centrosymmetric, with a molecular weight of 244.06 g/mol. Tetrahydroquinolin-2(1H)-one can be used as a ligand for metals such as chlorine and magnesium. It does not dissolve in water but does dissolve in organic solvents such as ethers, chloroform, or benzene.

5-Phenyl-1H-pyrazin-2-one is a potent inhibitor of tyrosine kinase, which is an enzyme that regulates the activity of cells by transferring phosphate groups from ATP to tyrosine residues. This drug binds to the ATP binding site, resulting in inhibition of the enzyme's activity and reduced cell proliferation. 5-Phenyl-1H-pyrazin-2-one has been shown to be effective in treating rheumatoid arthritis and other autoimmune diseases, with no adverse effects on bone metabolism or blood pressure. It also has no effect on platelet aggregation or erythrocytes.

Versatile small molecule scaffold

3,5-Dichlorophthalic acid is a divalent organic acid that is used as an intermediate in the production of other chemicals. 3,5-Dichlorophthalic acid is used as a regulator of plant growth and development. It can also be used to make different n-substituted compounds, such as naphthalene, phthalic anhydride, and 2,6-dichloro-pyridine.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Allylcyclohexanone is an unsaturated ketone that is synthesized by the ring-opening of allyl cyclohexane carboxylate with sodium hydroxide. It can be used as a chemical intermediate for the synthesis of other compounds. 2-Allylcyclohexanone can also be used to react with hydroxide solution to produce a salt and an alcohol. The hydroxide solution can act as a base, reducing the carbonyl group in the presence of an acid to form the corresponding alcohol. This reaction is stereoselective because it only occurs when there are two different groups on adjacent carbons.
2-Allylcyclohexanone has been shown to inhibit non-nucleoside reverse transcriptase inhibitors (NNRTIs) such as nevirapine, efavirenz, and delavirdine. In addition, it has been found to have functional groups that are capable of reacting

Vinyltributyltin is a dibutyltin oxide (DBTO) enantiomer that has been shown to inhibit the HIV-1 protease. Vinyltributyltin has also been shown to reduce inflammation in bowel disease, as well as to have synergistic effects with other drugs in the treatment of cancer and inflammatory bowel disease. The mechanism of action of vinyltributyltin is not yet known, but it may be related to its ability to inhibit the quinazolone-dependent formation of reactive oxygen species. Vinyltributyltin also inhibits the NS3 protease, which is an enzyme involved in hepatitis C virus replication.

JNJ 37822681 is a novel, potent, and selective small molecule inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the degradation of anandamide, a cannabinoid receptor ligand. The compound has been shown to be efficacious in animal models predictive of antipsychotic activity.