Building Blocks

<p>Applications N,N-Dicyclohexylmethylamine is used as a reagent in the base preparation of 13C2- and 2H phenethylamines as internal standards for IDMS by Pd-catalyzed double carbonylation of aryl iodides in the presence of amine nucleophiles followed by deoxygenation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nielsen, D., J. Org. Chem., 74, 6155 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.<br>References Bhat, S. et al.: J. Hetero. Chem., 52, 1253 (2015); Xu, R. et al.: J. Labelled. Comp. Radiopharm., 58, 308 (2015);<br></p>

<p>Applications Dicyclohexyl Ketone (cas# 119-60-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Has binding affinity to guanine deaminase, an important metalloenzyme in purine catabolism. Found in urine of patients with malignant cancer.<br>References Fernandez, J. et al.; Bioorg. Med. Chem.; 18, 6748 (2010); Li, H. et al.; J. Mass. Spectrom. 44, 641 (2009)<br></p>

<p>Stability Unstable in acidic solution<br>Applications Trimethyl Orthovalerate is used in the synthesis of dihydropyran-4-ones, via the Maitland-Japp reaction, which can be converted stereoselectively into tetrahydropyran-4-ones. This conversion is useful in the study of the functionalized tetrahydropyran units that are found in the anticancer polyketide lasonolide A and the Civet fragrance which is used in perfumery.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Clarke, P., et al.: Org. Biomol. Chem., 13, 4743 (2015)<br></p>

<p>Applications Pyruvaldehyde is used in the synthesis and cytotoxicity evaluation of N-terminal analogues of tubulysin-U an antimitotic compound. Also used in the synthesis of imidazoles as potent calcitonin gene-related CGRP antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shankar, S. et al.: Tetrahedron Lett., 54, 6137 (2013); Tora, G. et al.: Bioorg. Med. Chem. Lett., 23, 5684 (2013);<br></p>

<p>Applications Dithiocarbamate complexes serve as hosts for the specific binding of various metal cations.<br>References Bourson, J., et al.: J. Phys. Chem., 97, 4552 (1993), Lai, S., et al.: Inorg. Chem., 38, 4262 (1999),<br></p>

<p>Applications Trimebutine (T795605) impurity standard.<br>References Wang, J., et al.: Br. J. Pharmacol., 113, 945 (1994), Chen, D., et al.: Bioorg. Med. Chem., 5, 1715 (1997), Min, H., et al.: Bioorg. Med. Chem. Lett., 18, 523 (2008),<br></p>

<p>Applications Trans, trans, trans-1,5,9-cyclododecatrene - (CAS# 676-22-2) is a useful research chemical compound.<br></p>

<p>Stability Hygroscopic<br>Applications N-Methylguanidine is an alkylated guanidine which shows inhibitory action against trypsin catalysis. N-Methylguanidine inhibited metabolism of certain hepatic drugs that was mediated by cytochrome P 450 protein in human liver microsome and hepatocyte.<br>References Inagami, T. et al.: Biochemistry, 7, 4045 (1968); Hanada, K. et al.: Nephron, 103, 179 (2006);<br></p>

<p>Applications 2-Methylvaleraldehyde (cas# 123-15-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,4,5,6-Tetra(9H-carbazol-9-yl)isophthalonitrile is an organic fluorescent dye.<br>References Uoyama, Hiroki., et al.: Nature (London, United Kingdom), 492, 234(2012); Kim, Bo Seong., et al.: Adv. Funct. Mater.,  24, 3970 (2014);<br></p>

<p>Applications 4-Chlorobenzonitrile<br></p>

<p>Applications N-Methylformanilide is an aromatic reagent used in the synthesis of dye-sensitized solar cells. Also used in the synthesis of potent tyrosinase inhibitors.<br>References Meyer, T et al.: J. Org. Chem., 77, 3704 (2012); Nihei, K. et al.: Bioorg. Med. Chem. Lett., 14, 681 (2004);<br></p>

<p>Applications 17a-Oxa-D-homo-5β-androst-1-ene-3,17-dione is a metabolite in the urine of men following treatment with Δ1-testololactone, which is an idiopathic oligospermic infertility. Also, it is derived from Androstenedione (A637550), which is a testosterone precursor and metabolite with androgenic activity. Controlled substance (anabolic steroid).<br>References Yaeger, R. L., et al.: Drug Metab. Dispos., 13, 107-109 (1985); Walker, V.R., et al.: Anal. Biopchem., 234, 194 (1996), King, D.S., et al.: J. Am. Med. Assoc., 281, 2020 (1999)<br></p>

<p>Applications 3-Diethylaminophenol is used as a reagent in the synthesis of coumarin- and rhodamine-fused deep red fluorescent dyes.<br>References Chen, J., et al.: J. Org. Chem., 78, 6121 (2013)<br></p>