Building Blocks

<p>Applications trans-Cyclohexane-1,4-diamine (cas# 2615-25-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,4,6-Tritert-butylpyridine is used in the synthesis of acceptors in organic solar cells.<br>References Morgan, M., et al.: Chem. Comm., 55, 11095-11098 (2019)<br></p>

<p>Applications 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine-13C2 is a labelled 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (D416350), used in the preparation of pterin-based inhibitors.<br>References Hevener, K. et al.: J. Med. Chem., 53, 166 (2010)<br></p>

<p>Stability Moisture, Light Sensitive<br>Applications Used for derivatization, TLC and HPLC separation, and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2.<br>References Clin. Chim. Acta., 214, 195 (1993), Anal. Lett., 26, 429 (1993)<br></p>

<p>Applications Diethyl Benzylmalonate (cas# 607-81-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Diethyl Butylethylmalonate-d5 is the isotope labelled analog of Diethyl Butylethylmalonate, a derivative of Diethyl 2-n-Butylmalonate (D443880) which is a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria.<br>References Yang, S., et al.: Eur. J. Med. Chem., 86, 133 (2014); Shi, W., et al.: Bioorg. Med. Chem. Lett., 20, 3592 (2010)<br></p>

<p>Applications 1-Bromobutane-2,2,3,3,4,4,4-d7 (CAS# 223487-53-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Diethyl 2-n-Butylmalonate is used as a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria.<br>References Yang, S., et al.: Eur. J. Med. Chem., 86, 133 (2014); Shi, W., et al.: Bioorg. Med. Chem. Lett., 20, 3592 (2010)<br></p>

<p>Applications N-Boc-p-phenylenediamine is the boc protected compound of 1,4-Phenylenediamine (P319845). 1,4-Phenylenediamine is a hair dye component, paraphenylenediamine, as a contact allergen for treatment of inflammatory diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chugh, K., et al.: J. Med., 13, 131 (1982), Baud, F., et al.: J. Toxicol. Med., 4, 279 (1984), Ashraf, W., et al.: Human Exp. Toxicol., 13, 167 (1994),<br></p>

<p>Applications 3-Dimethylamino-1-propyne is used as a reactant in the synthesis of quinazoline derivatives such as (2Z)-Afatinib (A355305) which may be used in the treatment of some cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsou, H., et. al.: J. Med. Chem., 44, 2719 (2001)<br></p>

<p>Applications Dimethyl cyclopropane-1,1-dicarboxylate (cas# 6914-71-2) is a useful research chemical.<br></p>

<p>Applications Ethyl 3-benzoylacrylate is an impurity of Enalapril (E555250), an antihypertensive and an angiotensin-converting enzyme (ACE) inhibitor.<br>References Gross, M., et al.: J. Pharmacol. Exp. Ther., 216, 552 (1980), Gomez, H.J., et al.: J. Cardiovasc. Pharmacol., 15, Suppl. 3, S26-S29, (1990), MacFadyen, J., et al.: Clin. Pharmacokinet., 25, 274 (1993), Malini, P.L.: Adv. Ther., 10, 253 (1993),<br></p>

<p>Applications is a building block used in various chemial synthesis such in the preparation of 6-(carboxymethylureido)-(±)-nicotine (CMUNic), nicotine immunogen, and  imidazo[1,2-c]-quinazoline-2,5-(3H,6H)dione.<br>References Y Hieda et. al,: The Journal of pharmacology and experimental therapeutics, 283(3), undefined (1998-2-12); Papadopoulos EP.Journal of Heterocyclic Chemistry 18(3), 515-518,<br></p>

<p>Applications Ethyl Carbazate is used in the synthesis of P1 aryl heterocycle-based thrombin inhibitors. It can be also used to prepare diazenedicarboxamides as inhibitors of alanylalanine ligase.<br>References Young, M., et al.: J. Med. Chem., 47, 2995 (2004); Kovac, A., et al.: Bioorg. Med. Chem. Lett., 17, 2047 (2007)<br></p>

<p>Applications Ethyl 2-Oxo-2-(2-oxotetrahydrofuran-3-yl)acetate is an intermediate formed in the synthesis of 5-[[(Dimethylamino)iminomethyl]amino]-2-oxopentanoic Acid (D471015), a metabolite of asymmetric dimethylarginine.<br>References Martens-Lobenhoffer, J. et al.: Anal Biochem., 419, 234 (2011)<br></p>

<p>Applications 4-​Hydroxy-​7-​methoxy-6-​quinolinecarboxamide​ is useful in the synthetic preparation of Lenvatinib (L329400(P)) with high purity. Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.<br>References Liu, S., et al.: Faming Zhuanli Shenqing (2020), CN 111377865 A; Matsui, J., et al.: Clin. Cancer Res., 14, 5459 (2008); Gild, M., et al.: Nature Rev. Endocrinol., 7, 617 (2011)<br></p>

<p>Applications cis-2-Hexen-1-ol is used in the invention of a repellent for Oryzaephilus surinamensis.<br>References Xu, W., et al.: Faming Zhuanli Shenqing (2017), CN 107258786 A 20171020<br></p>

<p>Applications Used in a novel process for preparing β-hydroxy-fatty acids which are useful as base material for lipids A, LB films, cosmetics, liquid crystals etc.<br>References Hanahan, D., et al.: J. Mol. Biol., 166, 557 (1983), Yang, S., et al.: Biotechnol. Bioeng., 43, 1124 (1994), Ramsay, J., et al.: Can. J. Microbiol., 41, 262 (1995), Rehm, B., et al.: Intl. J. Biol. Macromol., 25, 3 (1999),<br></p>

<p>Applications 5-Hydroxy-2-oxo-2,3-dihydro-1H-[1]benzazephe-4-carboxylic Acid Ethyl Ester (cas# 108993-98-2) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>