Building Blocks

<p>Applications An intermediate in the formation of L-egothioneine, a natural amino acid ubiquitously present in cells and tissues of most plants and mammalian species. In humans, L-ergothioneine is found in red blood cells, liver, kidney, brain, seminal fluid, and cataract-free lenses at concentrations ranging from 100 uM to 2 mM. L-ergothioneine is exclusively biosynthesized in fungi and mycobacteria. Hence, humans assimilate it through dietary intake.L-ergothioneine has been proven to act as an antioxidant in vivo and to afford protection from g and UV radiation as well as from singlet oxygen in vivo. Recently, it has been shown that L-ergothioneine protects isolated perfused heart against the deleterious effect of post-ischemic reperfusion.The intermediate, 2-mercaptohistine has been used for the<br>References Makinen, K.K., et al.: Eur. J. Biochem., 123, 171 (1982), Howard, R.J., et al.: Biochem. Pharmacol., 35, 1589 (1986),<br></p>

<p>Applications p-Chloroacetophenone is a chemical reagent used in the synthesis of various pharmaceutically and biologically active compounds such as COX-2 inhibitors.<br>References Penning, T. et al.: J. Med. CHem., 40, 1347 (1997); Wolfe, J. et al.: Angew. Chem. Int. Ed., 38, 2413 (1999);<br></p>

<p>Stability Air and Moisture Sensitive<br>Applications Dangerous for the environment.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4,5-Dimethyl-3-isoxazolamine is an isoxazole derivative used in the preparation of a varitey of biologically active compounds such as selective ETA receptor antagonists.<br>References Murugesan, N. et al.: J. Med. Chem., 46, 125 (2003);<br></p>

<p>Applications 1,3-Benzothiazole-4-sulfonyl Chloride (cas# 149575-65-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (±)-3-Heptanol, is a volatile components of various plants, and can be used as flavor and fragrance ingredients. It is also used as building block used for the synthesis of various chemicals. It is used for the preparation of biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, I., et al.: Bioorg. Med. Chem. Lett., 55 (18), 5889 (2012); Gibka, J., et al.: Zeszyty Naukowe - Politechnika Lodzka, 60, 65 (1998);<br></p>

<p>Applications 2,4,6-Collidine is an reagent used for various synthetic preparations such as the synthesis of methylated pyridines by three-componet catalytic condensation of acetylene, acetone and ammonia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pertel, S.S., et al.: Carbohydrate. Rsch., 356, 172 (2012); Kung, A. C., et al.: J. Org. Chem., 70, 3127 (2005);<br></p>

<p>Stability Volatile<br>Applications Hexamethyldisilane is an organic silylating and disilylating reagent. It is also a useful reagent for reductive coupling, reductive deuteration, aroylarylation, carbosilylation, insertion, deuteration and dimerization reactions.<br>References Xiao, G., et al.: Tetrahedron Lett., 59, 1836 (2018); Lu, A., et al.: Angew. Chem. Int. Ed., 57, 3233 (2018); Deb, M., et al.: New J. Chem., 41, 14528 (2017); Hiyama, T., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2010)<br></p>

<p>Applications is a building block used in various chemial synthesis such in the preparation of 6-(carboxymethylureido)-(±)-nicotine (CMUNic), nicotine immunogen, and  imidazo[1,2-c]-quinazoline-2,5-(3H,6H)dione.<br>References Y Hieda et. al,: The Journal of pharmacology and experimental therapeutics, 283(3), undefined (1998-2-12); Papadopoulos EP.Journal of Heterocyclic Chemistry 18(3), 515-518,<br></p>

<p>Applications Isobutyric Anhydride is used as a highly reactive and non-water producing acyl donor for hydrolase-catalyzed enantioselective esterification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, J.-H., et al.: Appl. Microbiol. Biot., 43, 402 (1995)<br></p>

<p>Applications 2-​Amino-​6-​methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Kα).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miller, M. S., et al.: Bioorg. Med. Chem., 25, 1481-1486 (2017);<br></p>

<p>Applications 3-(Dimethylamino)-1,2-propanediol is a reagent in the synthesis of 1,2-Dioleoyl-3-trimethylammonium-propane, Chloride (D484450).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-BENZYLADENINE (cas# 7280-81-1) is a useful research chemical.<br></p>

<p>Applications N,N-Dimethylmethyleneiminium Iodide (cas# 33797-51-2) is a useful research chemical.<br></p>

<p>Applications 5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.<br>References Hasegawa, M., et al.: J. Med. Chem., 50, 4453 (2007); Okaniwa, M., et al.: J. Med. Chem., 55, 3452 (2012)<br></p>

<p>Applications 1-Dodecyne (CAS# 765-03-7) is a useful research chemical compound.<br></p>

<p>Applications 6-Chloro-1-hexanol is used as a reagent in the synthesis of 3-(4-Chloro butyl)-1H-indole-5-carbonitrile; a key intermediate of the antidepressant drug Vilazodone (V265000).<br>References Anitha, N., et al.: Synthetic Commun., 44, 3563 (2014)<br></p>

<p>Applications Tri-n-butyl Borate is used as a catalyst in the formation of dihydropyrimidinones under solvent-free microwave-assisted conditions.<br>References Ranjith, Choorikkat, et al.: Bullet. of the Chem. Soc. of Jap., 83(3), 288-290 (2010)<br></p>