Building Blocks

<p>Applications 2-Bromopropionic Acid is a versatile reactant used in emulsion polymerization in the preparation of reversible addition-fragmentation chain transfer (RAFT) agent.<br>References Ferguson, C., et al.: Macromolecules, 35, 9243 (2002); Ferguson, C., et al.: Macromolecules, 38, 2191 (2005);<br></p>

<p>Applications 3,5-Diiodosalicylic Acid is an metabolite of Aspirin (A187780), an anti-inflammatory, anti-platelet and cancer-preventive agent. 3,5-Diiodosalicylic Acid was shown to exhibit agonist activity at GPR35, a orphan G protein coupled receptor.<br>References Deng, H.Y., et al.: Arch. Pharmacol., 385, 729 (2012); Blandin, V., et al.: Molec. Pharmacol., 58, 1461 (2000);<br></p>

<p>Applications 2,2-Difluoropropionic acid (cas# 373-96-6) is a useful research chemical.<br></p>

<p>Applications 3-Methyl-2-buten-1-ol can be used as an additive to improve the antiknock properties of gasoline.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mack, J. Hunter, et al.: Fuel, 117(PB), 939-943 (2014)<br></p>

<p>Applications 5-Nitroisoquinoline (cas# 607-32-9) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate in the formation of L-egothioneine, a natural amino acid ubiquitously present in cells and tissues of most plants and mammalian species. In humans, L-ergothioneine is found in red blood cells, liver, kidney, brain, seminal fluid, and cataract-free lenses at concentrations ranging from 100 uM to 2 mM. L-ergothioneine is exclusively biosynthesized in fungi and mycobacteria. Hence, humans assimilate it through dietary intake.L-ergothioneine has been proven to act as an antioxidant in vivo and to afford protection from g and UV radiation as well as from singlet oxygen in vivo. Recently, it has been shown that L-ergothioneine protects isolated perfused heart against the deleterious effect of post-ischemic reperfusion.The intermediate, 2-mercaptohistine has been used for the<br>References Makinen, K.K., et al.: Eur. J. Biochem., 123, 171 (1982), Howard, R.J., et al.: Biochem. Pharmacol., 35, 1589 (1986),<br></p>

<p>Stability Moisture Sensitive<br>Applications 10-Bromodecanol can be used to synthesize rotaxane dendrimers. It can also be used to synthesize J2326, a molecule that induces neurite outgrowth in neuronal cells.<br>References Wei, W., et al.: Proc. Natl. Acad. Sci. USA 112, 5597 (2015); Chang, P., et al.: Neuropharmacology 92, 146 (2015)<br></p>

<p>Applications N,N-DIMETHYLFORMAMIDE DINEOPENTYL ACETAL (cas# 4909-78-8) is a useful research chemical.<br></p>

<p>Applications 2-Nitro-4,5-methylenedioxybenzaldehyde (cas# 712-97-0) is a compound useful in organic synthesis.<br>References Kajihara, Y., et al.: Carb. Res., 331, 455 (2001)<br></p>

<p>Applications 3,4,5-Trimethoxytoluene is a reagent for oxadiazolylindazole sodium channel modulators which are neuroprotective toward hippocampal neurons.<br>References Clutterbuck, L. A., et al.: J. Med. Chem., 52, 2694 (2009);<br></p>

<p>Applications 4-​Hydroxy-​7-​methoxy-6-​quinolinecarboxamide​ is useful in the synthetic preparation of Lenvatinib (L329400(P)) with high purity. Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.<br>References Liu, S., et al.: Faming Zhuanli Shenqing (2020), CN 111377865 A; Matsui, J., et al.: Clin. Cancer Res., 14, 5459 (2008); Gild, M., et al.: Nature Rev. Endocrinol., 7, 617 (2011)<br></p>

<p>Applications 4-(4'-Bromophenyl)-4-hydroxypiperidine is a metabolite of bromoperidol.<br>References Wong, F. A., et al.: Drug Metab. Dispos., 11, 301 (1983); Lyles-Eggleston, M. D., et al.: Med. Chem. Res., 9, 686 (1999); Sato, S., et al.: Pharmacol. Toxicol., 86, 145 (2000)<br></p>

<p>Applications A metabolite of Tryptophan-niacin.<br>References Yuyama, S. et al.: Adv. Exp. Med. Biol. 294, 475 (1991).<br></p>

<p>Applications A substituted alkynyl phenoxy compound as new synergists in pesticidal compositions.<br>References Hefner,T., et al.: Bioorg. Med. Chem., 10, 1731 (2002),<br></p>

<p>Applications 3-Bromoquinoline (cas# 5332-24-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,5-DIMETHOXYTETRAHYDROFURAN (cas# 696-59-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethyl 2-Oxo-2-(2-oxotetrahydrofuran-3-yl)acetate is an intermediate formed in the synthesis of 5-[[(Dimethylamino)iminomethyl]amino]-2-oxopentanoic Acid (D471015), a metabolite of asymmetric dimethylarginine.<br>References Martens-Lobenhoffer, J. et al.: Anal Biochem., 419, 234 (2011)<br></p>