Building Blocks

<p>Applications An intermediate for the synthesis of many biologically active molecules including receptor ligands and enzyme inhibitors<br>References Miyashita, A., et al.: Chem. Pharm. Bull., 45, 1235 (1997), Collins, I., et al.: J. Med. Chem., 45, 1887 (2002), Miller, W.H., et al.: Bioorg. Med. Chem. Lett., 13, 1483 (2003),<br></p>

<p>Applications 2-Iodobenzenamine is an synthetic intermediate for the synthesis of complex organic compounds and pharmaceuticals.<br>References Liu, J., et al.: Synthesis., 45, 943 (2013); Rambabu, D., et al.: Bioorg. Med. Chem. Lett., 23, 1351 (2013);<br></p>

<p>Applications N-Boc-pyrrolidine is a boc-protected cyclic amine used as a building block in the preparation of diastereomers by usually undergoing α'-lithiations and electrophilic substitution reactions.<br>References Beak, P. et al.: J. Org. Chem., 58, 1109 (1993);<br></p>

<p>Applications 4-Pyridinecarboxaldehyde, is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.<br>References Ulloora, Sh., et al.: Ehro. J. Med. Chem., 70, 341 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications 3-Furaldehyde is a volatile compound of honey of various floral origin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alissandrakis, E., et al.: Food Chem., 100, 396 (2007), Baltrusaityte, V., et al.: Food Technol. Biotechnol., 45, 201 (2007),<br></p>

<p>Applications Boronic acid derivatives and their binding affinities with diols.<br>References Yang, W., et al.: Bioorg. Med. Chem. Lett., 12, 2175 (2002), Yang, W., et al.: Med. Res. Rev., 23, 346 (2003),<br></p>

<p>Applications 4-Pentenal acts as a reagent used in the screening of the phytochemical, antibacterial and cytotoxic activity of medicinal plant of Tamilnadu.<br>References Nameirakpam, N. D., et al.: Int. J. Pharm. Res. BioSci., 1 (2012)<br></p>

<p>Applications 2-Bromo-3'-hydroxyacetophenone (cas# 2491-37-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl Cyanoformate (cas# 623-49-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl Carbazate is used in the synthesis of P1 aryl heterocycle-based thrombin inhibitors. It can be also used to prepare diazenedicarboxamides as inhibitors of alanylalanine ligase.<br>References Young, M., et al.: J. Med. Chem., 47, 2995 (2004); Kovac, A., et al.: Bioorg. Med. Chem. Lett., 17, 2047 (2007)<br></p>

<p>Applications 3-Iodobenzonitrile<br></p>

<p>Applications Benzoic Anhydride is the more active analogue of benzoic acid formed via dehydration. Benzoic Anhydride is used in the synthesis of a wide range of organic compounds including some dyes. Benzoic Anhydride is also used as an arylation agent in the Heck reaction.<br>References Lewis, D.M. et al.: J. Soc. Dyes Col., 99, 354 (1983); Shmidt, A.F. et al.: Kin. Catal., 41, 743 (2000);<br></p>

<p>Applications Ethyl 2-Oxo-2-(2-oxotetrahydrofuran-3-yl)acetate is an intermediate formed in the synthesis of 5-[[(Dimethylamino)iminomethyl]amino]-2-oxopentanoic Acid (D471015), a metabolite of asymmetric dimethylarginine.<br>References Martens-Lobenhoffer, J. et al.: Anal Biochem., 419, 234 (2011)<br></p>

<p>Applications 3-Methoxybenzyl chloride is a chemical reagent used to benzylate sugars (e.g. 2-Deoxy-D-ribose [D252000]) and also used to alkylate amides (e.g. Benzyl acetoacetic amide [B222950]).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cheng, M., et al.: Org. Biomol. Chem., 4, 510 (2006); Martin, O., et al.: J. Org. Chem., 53, 3287 (1988)<br></p>

<p>Applications 1,4-Cyclohexanedione, is a versatile building block in the synthesis of more complex compounds. This intermediate can be hydrolysed and decarboxylated to afford the desired dione.<br>References Nielsen. A.T., et al.: Org. Synth.,;Coll., 5, 288 (1973);<br></p>

<p>Applications N-(4-Bromobutyl)phthalimide is used in the preparation of β-cyclodextrin derivatives that block the pore formed by protective antigen for the inhibition of the action of anthrax toxin.<br>References Karginov, V.A., et. al.: Bioorg. Med. Chem., 14, 33 (2006)<br></p>

<p>Stability Volatile<br>Applications Hexamethyldisilane is an organic silylating and disilylating reagent. It is also a useful reagent for reductive coupling, reductive deuteration, aroylarylation, carbosilylation, insertion, deuteration and dimerization reactions.<br>References Xiao, G., et al.: Tetrahedron Lett., 59, 1836 (2018); Lu, A., et al.: Angew. Chem. Int. Ed., 57, 3233 (2018); Deb, M., et al.: New J. Chem., 41, 14528 (2017); Hiyama, T., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2010)<br></p>

<p>Applications Propyl Acetoacetate is used as a reagent in the synthesis of 3,4-dihydropyrimidin-2(1H)-ones as a novel class of potent and selective A2B adenosine receptor antagonists.<br>References Crespo, A., et al.: ACS Med. Chem. Lett., 4, 1031 (2013)<br></p>