Building Blocks

<p>Applications 3-Dimethylamino-1-propyne is used as a reactant in the synthesis of quinazoline derivatives such as (2Z)-Afatinib (A355305) which may be used in the treatment of some cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsou, H., et. al.: J. Med. Chem., 44, 2719 (2001)<br></p>

<p>Applications 1,4-Dimethoxy-2-methylbenzene (cas# 24599-58-4) is a useful research chemical.<br></p>

<p>Applications 2,4,6-Trichlorobenzoyl Chloride, can be used for the preparation of large-ring lactones in high yields. It is used for the syntheisis of cytotoxic marine natural product Amphidinolide X and Jasplakinolide (J210700).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fieser, M. Reagents for Organic Synthesis New York 16, 353, (1992); Lepage, O., et al.: J. Amer. Chem. Scoi., 126 (49), 15970<br></p>

<p>Applications Ammonium sulfide is a very useful reagent in various aspects ranging from large scale production of textile manufacture, trace metal analysis, patina to bronze, and as well as cell culture and organic reactions/synthesis. Recently it has been used as a cleaning solution in the study of semiconductor growth on indium phosphide with various metals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferrandis, P., et al.: J. Appl. Phys., 123, 161534/1-161534/10 (2018)<br></p>

<p>Stability Moisture and Acid Sensitive<br>Applications (1-Methoxy-2-methylprop-1-enoxy)trimethylsilane is useful in the synthesis of organic compounds such as 1,​1'-​Bis[1-​(1-​methoxycarbonyl-​1-​methyl-​ethyl)​-​3-​butenyl] Ferrocene Monome, Alkylbismuths and N-​Tosyl-α,​β-​dehydroamino Esters.<br>References Espinosa, M., et al.: RC Adv., 6, 15655 (2016); Nishimoto, T., et al.: Chem. Eur. J., 19, 14411 (2013); Wang, J., et al.: Faming Zhuanli Shenqing, CN 103665053 A 20140326 (2014)<br></p>

<p>Applications rac-Trifluorolactic Acid is a derivative of DL-Lactic Acid (L113490) which occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity.<br>References He, W. et al.: Comp. Biochem. Phys. Part A: Mol. Int. Phys., 166, 308 (2013)<br></p>

<p>Applications Triisopropyl Borate is a borate ester used in Suzuki couplings.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wolfe, J. et al.: J. Am. Chem. Soc., 121, 9550 (1999); Darses, S. et al.: Eur. j. Org. Chem., 8, 1875<br></p>

<p>Applications 4-methyl-3-oxoheptanenitrile (cas# 1039833-22-1) is a useful research chemical.<br></p>

<p>Applications 3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, R., et. al.: J. Med. Chem., 56, 6069 (2013)<br></p>

<p>Applications 2-Bromothiazole is a heterocyclic S compound to induce base-pair substitution and having mutagenic activity.<br>References Voogd, C.E., et al.: Mutation Research, Genetic Toxicology Testing, 118, 153 (1983),<br></p>

<p>Applications Reagent used in the preparation of many pharmaceutically active compounds such as antiulcer agents, antitumor agents, antibiotics and anxiolytics.<br>References Colabufo, N., et al.: J. Med. Chem., 51, 7602 (2008), Manfroni, G., et al.: Bioorg. Med. Chem. Lett., 19, 714 (2009),<br></p>

<p>Applications 4-​Hydroxy-​7-​methoxy-6-​quinolinecarboxamide​ is useful in the synthetic preparation of Lenvatinib (L329400(P)) with high purity. Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.<br>References Liu, S., et al.: Faming Zhuanli Shenqing (2020), CN 111377865 A; Matsui, J., et al.: Clin. Cancer Res., 14, 5459 (2008); Gild, M., et al.: Nature Rev. Endocrinol., 7, 617 (2011)<br></p>

<p>Applications Methyl chlorodifluoroacetate<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Methyl-2-buten-1-ol can be used as an additive to improve the antiknock properties of gasoline.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mack, J. Hunter, et al.: Fuel, 117(PB), 939-943 (2014)<br></p>

<p>Applications cis-2-Hexen-1-ol is used in the invention of a repellent for Oryzaephilus surinamensis.<br>References Xu, W., et al.: Faming Zhuanli Shenqing (2017), CN 107258786 A 20171020<br></p>

<p>Applications 1,4-Bis(diphenylphosphino)butane is a catalyst precursor used in organic synthesis such as the preparation of phenanthrothiazoles.<br>References Shi, X. et al.: J. Org. Chem., 82, 3886 (2017);<br></p>

<p>Applications 3-Mercaptophenol is a versatile reactant used in the study of mechanism and catalysis of the native chemical ligation reaction. It was also used as a reactant in the synthesis and biological evaluation of HSP90 inhibitors based on molecular dynamic calculated conformational analysis of radicicol and its analogs.<br>References Moulin, E., et al.: J. Am. Chem. Soc., 127, 6999 (2005); Johnson, E., Kent, S.: J. Am. Chem. Soc., 128, 6640 (2006);<br></p>

<p>Stability Light Sensitive<br>Applications 3-Furaldehyde is a volatile compound of honey of various floral origin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alissandrakis, E., et al.: Food Chem., 100, 396 (2007), Baltrusaityte, V., et al.: Food Technol. Biotechnol., 45, 201 (2007),<br></p>