Building Blocks

<p>Applications 1-(Phenylmethyl)-4-piperidinamine is used in the preparation of 4-substituted coumarins as novel acetylcholinesterase inhibitors used in the treatment and various therapeutic approaches to Alzheimer’s disease. It is also used in the synthesis of nicotinamide derivatives as anti-angiogenic agents.<br>References Razavi, S. et al.: Eur. J. Med. Chem., 64, 252 (2013); Choi, H. et al.: Bioorg. Med. Chem. Lett., 23, 2083 (2013);<br></p>

<p>Applications Diallylmalonic Acid is an intermediate in the synthesis of metabolites of Valproic Acid (V094750) as anticonvulsant agents. It can also be used for the synthesis of Velbanamine.<br>References Zielinski, G. K., et al.: Org. Biomolec. Chem., 13, 2684 (2015):<br></p>

<p>Applications 2-Hydroxyphenylacetic Acid (cas# 614-75-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 2-Mercaptoacetate is an off-odor compound in white wine and an eye irritant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nikolantonaki, M., Darriet, P.: J. Agr. Food Chem., 59, 10191 (2011); Bagley, D.M., et. al.: Toxicol. in vitro, 13, 505 (1999)<br></p>

<p>Applications α-Desethyl Butamirate is an impurity in the synthesis of Butamirate (B690025), an antitussive drug.<br>References Wang, T., et al.: J. Pharm. Biomed. Anal., 23, 867 (2000), Lasztity, A., et al.: Microchem. J., 73, 59 (2002), Wang, L., et al.: J. Pharm. Biomed. Anal., 33, 961 (2003), Lewen, N., et al.: J. Pharm. Biomed. Anal., 35, 739 (2004),<br></p>

<p>Impurity Indomethacin EP Impurity B<br>Applications N-Deschlorobenzoyl Indomethacin (Indomethacin EP Impurity B) is a metabolite of Indomethacin.<br>References O'Brien, W., et al.: Clin. Pharmacol. Ther., 9, 94 (1968), Duggan, D., et al.: J. Pharmacol. Exp. Ther., 181, 563 (1972), Abourashed, E., et al.: Curr. Med. Chem., 6, 359 (1999), Chatterjee, P., et al.: J. Nat. Prod., 62, 761 (1999),<br></p>

<p>Stability Air Sensitive, Hygroscopic<br>Applications 2-Ethylhexyl-4-aminobenzoate is an impurity in the synthesis of Ethylhexyl Triazone (E918810), used in sunscreen formulations as a UV filter to block out harmful ultraviolet light.<br>References Potard, G. et al.: Int. J. Pharm., 189, 249 (1999); Couteau, C. et al.: J. Pharm. Biomed. Anal., 44, 270 (2007);<br></p>

<p>Applications An metabolite of Cotinine. In equilibrium with 5’-Hydroxycotinine the cyclized form.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Morselli, P.L, et al.: J. Med. Chem., 10, 1033 (1967); Murphy, S.E. et. al.: Chem. Res. Toxicol. 12, 639 (1999)<br></p>

<p>Applications Mono-tert-butyl Succinate is a reagent used for the synthesis of fluorinated β2- and β3-amino acids, an inhibitor of α-chymotrypsin.<br>References Peddie, V., et al.: Synthesis, 1845-1859 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Deoxy-D-manno-2-octulosonic Acid Ammonium Salt is a ketosidic component in all lipopolysaccharides of Gram-negative bacteria and has been identified in several acidic exopolysaccharides (K-antigens). Synthetic analogues of KDO may be studied for their potential to disrupt the biosynthesis of bacterial cell-wall components, and lead to new antibacterial agents.<br>References Altschul, S., et al.: J. Mol. Biol., 215, 403 (1990), Baumann, H., et al.: Biochemistry, 31, 4081 (1992), Hashimoto, M., et al.: Eur. J. Biochem., 268, 3139 (2001), Kodar, K., et al.: Immunol. Invest., 38, 704 (2009),<br></p>

<p>Applications 2,4-DIAMINOPTERIDINE-6-CARBOXYLIC ACID (cas# 716-74-5) is a useful research chemical.<br></p>

<p>Impurity Ethinylestradiol EP Impurity I<br>Applications 6,7-Dehydro Ethynyl Estradiol (Ethinylestradiol EP Impurity I) is an Ethynyl Estradiol (E685100) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tettey-Amlalo, R., et al.: J. Pharm. Biomed. Anal., 50, 580 (2009), Neue, U., et al.: J. Sep. Sci., 2001, 24, 921 (2001),<br></p>

<p>Stability Hygroscopic<br>Applications DEET ω-Carboxylic Acid is a metabolite of DEET (D228500), an insect repellant commonly used to prevent contact with mosquitoes.<br>References Constantino, L. &amp; Iley, J.: Xenobiotica, 29, 409 (1999); Syed, Z. &amp; Leal, W.: P. Natl. Acad. Sci. USA, 105, 13598 (2008)<br></p>