Building Blocks

<p>Stability Corrosive<br>Applications Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, Li., et al.: Bioorg. Med. Chem., 18, 7948 (2010); Roberts, D.W., et al.: Chem Res. Toxicol., 23, 228 (2010);<br></p>

<p>Applications Ethyl Diazoacetate is used in the synthesis of Arteludovicinolide A as well as pyrimidoazepine analogs as seritonin 5-HT2A/C receptor ligands for treatment of obesity. This compound contains solvent for added stability.<br> E0<br>References Yang, H. et al.: Eur. J. Med. Chem., 63, 558 (2013); Kreuzer, A. et al.: Org. Lett., 15, 3420 (2013);<br></p>

<p>Applications This compound is an isomer of compound (E925685) used in the synthesis of neuraminidase inhibitors.<br>References Jarinrat K. et al.: Bioorg. Med. Chem. Lett., 20, 2152 (2012);<br></p>

<p>Applications Ethyl phenylacetate is one of the odour active components in a variety of foods such as mango (Mangifera indica L. cv. Corazon), guava wine, and soypaste.<br>References Pino, J.: Int. J. Food Sci. Tech., 47, 1944 (2012); Pino, J. &amp; Queris, O.: J. Agr. Food Chem., 59, 4885 (2011); Zhang, Y., et al.: Molecules, 15, 3421 (2010)<br></p>

<p>Applications Euscaphic Acid is a hypoglycemic natural product from Folium Eriobotryae with anti-inflammatory properties. Euscaphic Acid also downregulates NF-κB activations and inhibits LPS-induced inflammatory responses.<br>References Chen, J., et al.: Pharmazie. 63, 765 (2008); Kim, I. T., et al.: J Cell Biochem. 113, 1936 (2012)<br></p>

<p>Applications Ethyl 3-(4-Pyridyl)propiolate (cas# 66869-71-4) is a useful research chemical.<br></p>

<p>Applications An Acetanilide and Anisole derivative metabolite by liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pesenti, C., et al.: ChemBioChem., 5, 590 (2004), Sandford, G., et al.: J. Fluorine Chem., 128, 90 (2007),<br></p>

<p>Applications Used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs.<br>References Toyn, J.H., et al.: Yeast, 16, 553, 560 (2000)<br></p>

<p>Applications 4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chang, Y.A., et al.: Bioconjugate Chem., 3, 200 (1992); Liao, T.H., et al.: Anal. Biochem., 148, 365 (1985)<br></p>

<p>Applications 4-Fluorobenzoic Acid Methyl Ester, is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin (B595850).<br>References Wang, J., et al.: Zhongguo Yiyao Gongye Zazhi, 40, 247 (2009);<br></p>

<p>Applications Formamidine Sulfuric Acid is a reagent used in reduction and synthesis reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, Q. et al.: Carbon, 54, 36 (2013);<br></p>

<p>Applications Forest fires are actually beneficial for ecosystems, provided they don’t happen too often. After a fire, plants germinate and grow incredibly fast. 2H-Furo[2,3-c]pyran-2-one, KAR2, is a compound in smoke responsible for promoting the seed germination of a wide range of plant species. The researchers named the compounds “the karrikins”, for “karrik”, an aboriginal word for smoke.<br>References Sakuma, H., et al.: .Agric Biol. Chem., 45, 443 (1981), Stevens, J., et al.: Plant Soil, 298, 113 (2007), Nelson, D., et al.: Plant Physiol., 149, 863 (2009),<br></p>

<p>Applications Furoyl Chloride is used in the preparation of novel dibenzothiepins that show antibiofilm activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stecoza, C. et al.: Curr. Org. Chem., 17, 113 (2013);<br></p>

<p>Applications Hexyl chloroformate is used as a derivatizing agent in organic synthesis, and is also used as a reagent to synthesize Dabigatran (D100090), an oral thrombin inhibitor used to prevent venous thromboembolism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eerenberg, E., et al.: Circulation, 124, 1573 (2011); Eriksson, B., et al.: Lancet, 370, 949 (2007); Maurino, V., et al.: J. Am. Soc. Mass Spec., 10, 1328 (1999); Simpson, J., et al.: J. Am. Soc. Mass Spec., 6, 525 (1995); van Ryn, J., et al.: Thromb. &amp; Haemo., 103, 1116 (2010)<br></p>

<p>Applications n-Hexyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 2241800-08-6) is a useful isotopically labeled research compound. This compound has been found to be an endocrine disruptor that was found in a study involving pantyhose.<br>References Li, A.,et.al., Environ.Sci.Technol., 52,10812-10819,(2018);<br></p>

<p>Applications Hexamethyldisilazane is used in the preparation of 5-azacytidine, an antineoplastic drug. Also used in the preparation of β3-AR agonists used in anti-stress formulations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vujjini, S. et al.: Org. Proc. Res. Dev., 17, 303 (2013); Xu, F. et al.: Org. Lett., 15, 1342 (2013);<br></p>

<p>Applications L-Histidine is an essential amino acid for human development which the body cannot produce on its own. L-Histidine is one of the 22 proteinogenic amino acids. L-Histidine precursor to histamine (H436500) and a component of carnosine.<br>References Kopple, J.D. et al.: J. Clin. Invest., 55, 881 (1975); Sachs, D.H., et al.: J. Biol. Chem., 246, 6576 (1971); Mercer, L.P., et al.: Nutrition, 6, 273 (1990); Morgan, W.T., et al.: J. Biol. Chem., 268, 6256 (1993);<br></p>