Building Blocks

<p>Applications Bicyclo[2.2.1]hept-2-ene is a catalyst used in many reactions such as in the cascade cyclizations of iodoarene, bromobenzylamine, and electron-deficient alkene derivatives and arene C-H amination with aryl halides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Narbonne, V., et. al.: Org. Lett., 16, 628 (2014); Dong, Z., Dong, G.: J. Am. Chem. Soc., 135, 18350 (2013)<br></p>

<p>Applications Glutaconic Acid is used in the synthesis of dialkyltin derivatives of dicarboxylic acids which display antitumor properties. Also used in the synthesis of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands with potential use for CNS illness treatments.<br>References Gielen, M. et al.: Hetero. Chem., 3, 449 (1992); Okubo, T. et al.: Bioorg. Med. Chem. Lett., 12, 3569 (2004);<br></p>

<p>Applications Caffeic Acid analog potentially having anti-inflammatory effects.<br>References Gardana, C., et al.: J. Pharm. Biomed. Anal., 45, 390 (2007), Falcao, S., et al.: Anal. Bioanal. Chem., 396, 887 (2010),<br></p>

<p>Stability Light Sensitive<br>Applications Protected Caffeic Acid<br>References Kurata, A., et al.: J. Biotechnol., 148, 133 (2010), Buzzi, F., et al.: Eur. J. Med. Chem., 44, 4596 (2009), Xu, G., et al.: Arch. Pharm., Res., 32, 1215 (2009),<br></p>

<p>Applications An impurity of the anti-convulsant (S)-Pregabalin (P704790).<br>References Lin, S. et al.: J. Liq. Chrom. Rel. Technol., 19, 2699 (1996); Sripathi, S. et al.: ARKIVOC, 10, 266 (2010);<br></p>

<p>Applications 1,2-Octanediol is a novel surfactant used in the treatment of head louse. Also used in the cosmetics industry in the formulations of sunscreen gels and eye make-up.<br>References Dayan, N. et al.: Cosmet. Toilet., 126, 186 (2011); Georgalas, A. et al.: Cosmet. Toilet., 127, 96 (2012); Burgess, I. et al.: PLoS One., 7, e35419, (2012)<br></p>

<p>Impurity Loratadine EP Impurity H<br>Applications N-Carbethoxy-4-piperidone (Loratadine EP Impurity H) is used in the preparation of 3-hydrazinopyridazines as antihypertensive agents as well as γ-carboline derivatives as potential serotonergic agents. N-Carbethoxy-4-piperidone is also an impurity of Loratadine (L469575).<br>References Schenker, E. et al.: Arsneim.-Forsch., 29, 1835 (1979); El-Kader, A. et al.: Mans. J. Pharm. Sci., 6, 1 (1989); Albu, M. et al.: J. Liq. Chrom. Rel. Technol., 32, 2569 (2009);<br></p>

<p>Applications 1-(2-Furyl)ethanol is an intermediate in the synthesis of 2H-Furo[2,3-c]pyran-2-one derivatives of their germination-promoting activity.<br>References Singh, V., et al.: Synthetic. Commun., 40, 1280 (2010);<br></p>

<p>Stability Light Sensitive<br>Applications 3-Phenyl-5-vinyl-1,2,4-oxadiazole is a chemical reagent used in the synthesis of pharmaceutically active motifs.<br>References Burns, A. et al.: Org. Biomol. Chem., 8, 2777 (2010); Catanese, B. et al.: Exp. Mol. Path. Supp., 2, 28 (1963);<br></p>

<p>Applications 3-Fluoro-4-methoxycarbonylphenylboronic acid, pinacol ester is a useful intermediate for organic synthesis and other chemical transformations.<br>References Zhao, F., et al.: Eur. J. Med. Chem., 134, 147 (2017); Zhao, F., et al.: Bioorg. Med. Chem., 24, 4281 (2016)<br></p>

<p>Applications Bis(2-butoxyethyl) 2-Hydroxyethyl Phosphate Triester is a metabolite of Tris(2-butyloxyethyl)phosphate (T875030), which is an organophosphate, that can be used in the preparation of flame retardant, such as viscose fiber.<br>References Wang, Y., et al.: Fangzhi Xuebao, 33, 16 (2012); Xiaoshan, L. et al.: Aquatic Toxicology, 114, 173 (2012);<br></p>

<p>Applications 3,6-Bis(hydroxymethyl)-2,5-piperazinedione is an intermediate in the synthesis of impurities of Cycloserine (C988800), an antibacterial agent.<br>References Shields, J. E., et al.: Biochem., 5, 1041 (1966); Hidy, P.H., et al.: J. Am. Chem. Soc., 77, 2345 (1955);<br></p>

<p>Applications Azodicarbonyl reagent used in the methods for determining levels of 1,25 dihydroxyvitamin d2 and d3 in biological and food samples and dietary supplements.<br>References Aranov, P. K. et al.: Anal. Bioanal. Chem., 391, 1917 ( 2008),<br></p>

<p>Impurity Solifenacin EP impurity A<br>Applications Solifenacin (S676700) intermediate.<br>References Andersson, K., et al.: Drugs, 35, 477 (1988), Wallis, R., et al.: Life Sci., 64, 395 (1999), Mitsuya, M., et al.: J. Med. Chem., 43, 5017 (2000), Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004),<br></p>

<p>Applications 2-Chloro-N,N-dimethylacetamide is N,M-dialkyl amide used as an organic catalyst in the preparation of phosphorylated thiosemicarbazide.<br>References Yanchuk, N.I. et al.: Zh. Obshch. Khim., 62, 1284 (1992); Yanchuk, N.I. et al.: 35, 568 (1994);<br></p>

<p>Applications 2-(2-Chloroethoxy)acetyl Chloride (cas# 39229-33-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Durban, M. et al.: Eur. J. Lipid. Sci. Tech., 105, 633 (2003);<br></p>

<p>Applications Sinorphan is an inhibitor of angiotensin-converting enzyme and neutral endopeptidase.<br>References Sulpizio, A.C., et al.: J. Pharmacol. Exp. Therap., 209, 1141 (2004); Takeda, Y., et al.: J. Hyper., 18, 927 (2000); Monteil, T., et al.: Syn. Comm., 31, 211 (2001);<br></p>