Building Blocks

<p>Stability Air Sensitive, Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications N-Acetyl-4-benzoquinone Imine (NAPQI) is a toxic metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). N-Acetyl-4-benzoquinone Imine can react with cysteine residues of hepatic proteins to yield Acetaminophen-cysteine (A161255) (4).<br>References (1) Jaeschke, H., et al.: Toxicol. Sci., 89, 31 (2006) (2) O’Malley G. F., et al.: J Med Toxicol. 11, 317 (2015)(3) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(4) Frey, S. M., et al.: J Med Toxicol. 11, 218 (2015)<br></p>

<p>Impurity Loratadine USP Related Compound E<br>Applications Loratadine impurity. Loratidine impurity E. Loratadine USP Related Compound E.<br>References Villani, et al.: J. Med. Chem., 15, 750 (1972), Zhong, D., et al.: Pharmazie, 49, 736 (1994), Ruperez, F., et al.: J. Pharm. Biomed. Anal., 29, 35 (2002),<br></p>

<p>Stability Light Sensitive<br>Applications 4,4’-Diaminostilbene-2,2’-disulfonic Acid, 95+% (cas# 81-11-8) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride is used as a reagent in the synthesis of valuable β-amylalkyl-β-amino acid enantiomers.<br>References Tasnadi, G., et al.: Org. Biomol. Chem., 8, 793 (2010)<br></p>

<p>Applications Trans, trans, trans-1,5,9-cyclododecatrene - (CAS# 676-22-2) is a useful research chemical compound.<br></p>

<p>Applications (cas# 526-83-0) is a useful research chemical.<br></p>

<p>Applications 4-Methylenepiperidine Hydrochloride is a building block that can be coupled with aryl halides via Suzuki cross-coupling to give benzyl piperidines and related compounds.<br>References Vice, S., et al.: J. Org. Chem., 66, 2487 (2001);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Deoxy-D-arabino-hexonic Acid Calcium Salt has been shown to not play a major role in the initial hydrothermal decarboxylation of biomass.<br>References Luijkx, G.C.A., et. al.: Carbohyd. Res., 272, 191 (1995)<br></p>

<p>Impurity Cefoperazone EP Impurity C<br>Applications N-Methyl-5-tetrazolethiol (Cefoperazone EP Impurity C) is an impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347(1982),<br></p>

<p>Applications 2-Cyano-6-Hydroxybenzothiazole (cas# 939-69-5) is a useful research chemical.<br></p>

<p>Applications Hexadecanoic-9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d17 Acid (CAS# 81462-28-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium 4-chlorophenoxyacetate (cas# 13730-98-8) is a useful research chemical.<br></p>

<p>Applications Cyclooctatetraene is used as a reactant in the synthesis of tricyclo[4.2.2.02,5]dec-9-ene-3,4,7,8-tetracarboxylic acid diimide, an antitumor drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vishnuvajjala, B.R., Cradock, J.C.: J. Pharm. Sci., 75, 301 (1986)<br></p>

<p>Stability Hygroscopic<br>Applications Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.<br>References Bhat, S. et al.: J. Hetero. Chem., 52, 1253 (2015); Xu, R. et al.: J. Labelled. Comp. Radiopharm., 58, 308 (2015);<br></p>

<p>Applications (2-Nitrophenyl)hydrazine (cas# 3034-19-3) is a useful research chemical.<br></p>

<p>Applications Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014); Keaney, E.P., et al.: Bioorg. Med. Chem. Lett., 24, 3714 (2014)<br></p>

<p>Applications 3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol.<br>References Hojati, S. F., et al.: Can. J. Chem., 88, 135 (2010);<br></p>