Building Blocks

<p>Impurity Cyclophosphamide Impurity A<br>Applications A cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard. Cyclophosphamide Impurity A<br>References Colvin, M. et al.: Cancer Res., 36, 1121 (1976); Ludeman, S. et al.: Drug Metab Dispos., 20, 337 (1992); Ludeman, S.M. et al.: J. Pharmaceut. Sci., 84, 393 (1995); Yu, L. et al.: Drug Metab. Dispos., 24, 1254 (1996);<br></p>

<p>Applications A 2-(N-Ethyl-m-toluidino)ethanol pigment system and lipoprotein lipase are used as a new glycerol oxidase determination method for serum triglyceride. 2-(N-Ethyl-m-toluidino)ethanol is also used in quantitative structure–activity relationship (QSAR) models that are developed to predict the aquatic toxicity of chemicals to the fathead minnow (Pimephales promelas).<br>References Tang, Xian-ping., et al. Xibei Guofang Yixue Zazhi, 33(4), 445-446 (2012); Papa, Ester., et al.: J. Chem. Inf. Model., 45(5), 1256-1266 (2005)<br></p>

<p>Applications 5-(Ethylthio)-1h-tetrazole<br></p>

<p>Applications A Penicillin metabolite used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.<br>References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010); Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010);<br></p>

<p>Stability Air Sensitive, Hygroscopic<br>Applications 2-Ethylhexyl-4-aminobenzoate is an impurity in the synthesis of Ethylhexyl Triazone (E918810), used in sunscreen formulations as a UV filter to block out harmful ultraviolet light.<br>References Potard, G. et al.: Int. J. Pharm., 189, 249 (1999); Couteau, C. et al.: J. Pharm. Biomed. Anal., 44, 270 (2007);<br></p>

<p>Applications Ethylenediamine Dihydrochloride (cas# 333-18-6) is a useful research chemical.<br></p>

<p>Applications Xylenesulfonic Acid is a hydrotrope used to solubilise hydrophobic compounds and in aqueous solutions as well is in the study of liposome systems.<br>References Friberg, S.E. et al.: J. Disp. Sci. Technol., 19, 19 (1998); Odeh, F. et al.: J. Disp. Sci. Technol., 27, 665 (2006);<br></p>

<p>Applications p-Toluic Acid is used as a reagent in the synthesis of several organic compounds including that of 2-aryl-1,3,4-oxadiazole derivatives which are potential antibacterial agents. Also used in the synthesis of 4-(bromomethyl) benzoic acid.<br>References Karimi, F., et al.: J. Chem. Pharm. Res., 7, 1028 (2015); Zheng, F., et al.: Guangdong Huagong, 42, 27 (2015);<br></p>

<p>Applications 2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds.<br>References Gallardo-Godoy, A., et al.: J. Med. Chem., 54, 1010 (2011); Lai, H., et al.: Antiviral. Res., 97, 74 (2013); Yamamoto, K.N., et al.: Environ. Molec. Mutagen., 52, 547 (2011);<br></p>

<p>Applications (1R,5S,6R)-Ethyl 5-(Pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate is the enantiomer of Ethyl (3R,4S,5S)-4,5-Epoxy-3-(1-ethylpropoxy)cyclohex-1-ene-1-carboxylate (E917820), an intermediate of Oseltamivir.<br>References Clark, C., et al.: J. Med. Chem., 31, 831 (1988)<br></p>

<p>Applications Ethyl difluoroacetate<br></p>

<p>Applications (E)-Ethyl 4-Bromo-3-methyl-2-butenoate (cas# 51318-62-8) is a compound useful in organic synthesis.<br></p>

<p>Impurity Solifenacin EP impurity A<br>Applications Solifenacin (S676700) intermediate.<br>References Andersson, K., et al.: Drugs, 35, 477 (1988), Wallis, R., et al.: Life Sci., 64, 395 (1999), Mitsuya, M., et al.: J. Med. Chem., 43, 5017 (2000), Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004),<br></p>

<p>Applications Byproduct produced in the preparation of Atropine.<br></p>

<p>Applications Ethyl 4-Bromobutanoate is a building block which has been used as a reactant for the preparation of firefly luciferase inhibitor-conjugated peptide derivatives.<br>References Poutiainen, P.K., et. al.: Bioconjugate Chem., 25, 4 (2014)<br></p>

<p>Applications A novel medical application of isothiocyanate ester in treating various leukemia, with low toxicity, which includes benzyl isothiocyanate, phenylethyl isothiocyanate, allyl isothiocyanate, sulforaphane, and erucin. Benzyl isothiocyanate (BITC) inhibits the growth of human pancreatic cancer cells by inducing apoptosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kubinyi, H., et al.: J. Cancer Res. Clin. Oncol., 116, 529 (1990), Sheridan, R., et al.: J. Med. Chem., 50, 3173 (2007), Sahu, R.P., et al.: Carcinogenesis, 30, 1744 (2009),<br></p>

<p>Stability Air Sensitive<br>Applications 2-Ethylhexanal, is an organic building block used in various chemical synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(N-Ethylanilino)ethanol can be used as a corrosion inhibitor. It can also be used as a reactant in the synthesis of a highly selective fluorescent probe for ALDH3A1-positive viable cells.<br>References Gupta, Meenakshi, et al.: Corrosao e Proteccao de Materiais, 31(1), 17-21 (2012);Yagishita, Atsushi, et al.: Bioconjugate Chem., 28(2), 302-306 (2017)<br></p>

<p>Applications Ethyl fluoroacetate is an inhibitor of insect juvenile hormone biosynthesis. It also shows toxic effects against Vibrio fischeri.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Quistad, Gary B., et al.: J. of Agri. and Food Chem., 30(6), 1151-4 (1982);Dawson, D. A., et al.: Archives of Envir. Contam. and Tox., 66(2), 248-258 (2014)<br></p>