Building Blocks

<p>Applications S-Propyl N,N-Diethyldithiocarbamate was shown to exhibit tuberculostatic activity and as well as pesticidal activities.<br>References Konecny, V., et al.: Agrochem., 7, 3 (1967); Baker, K., et al.: J. Pharmacol. Exp. Ther., 284, 215 (1998),<br></p>

<p>Applications (4-Bromophenyl)urea (cas# 1967-25-5) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Bromo-6-methyl-3H-1,3-benzodiazole<br></p>

<p>Stability Unstable in acidic solution<br>Applications Trimethyl Orthovalerate is used in the synthesis of dihydropyran-4-ones, via the Maitland-Japp reaction, which can be converted stereoselectively into tetrahydropyran-4-ones. This conversion is useful in the study of the functionalized tetrahydropyran units that are found in the anticancer polyketide lasonolide A and the Civet fragrance which is used in perfumery.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Clarke, P., et al.: Org. Biomol. Chem., 13, 4743 (2015)<br></p>

<p>Applications N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-[5-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]pentyl]-N1-hydroxybutanediamide, is a bifunctional chelator.<br></p>

<p>Stability Hygroscopic<br>Applications A novel labelled metabolite of Butadiene monoepoxide (BMO), a mutagen and carcinogen compound.<br>References Cheng, X., et al.: Drug Metab. Dispos., 21, 121 (1993), Nieusma, J., et al.: Chem. Res. Toxicol., 10, 450 (1997),<br></p>

<p>Stability Air Sensitive, Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications N-Acetyl-4-benzoquinone Imine (NAPQI) is a toxic metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). N-Acetyl-4-benzoquinone Imine can react with cysteine residues of hepatic proteins to yield Acetaminophen-cysteine (A161255) (4).<br>References (1) Jaeschke, H., et al.: Toxicol. Sci., 89, 31 (2006) (2) O’Malley G. F., et al.: J Med Toxicol. 11, 317 (2015)(3) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(4) Frey, S. M., et al.: J Med Toxicol. 11, 218 (2015)<br></p>

<p>Applications 3-Bromo-5-methoxypyridine<br></p>

<p>Applications A optically active metabolite of Tramadol.<br>References Lintz, V.W., et al.: Arzneim.-Forsch./Drug Res., 31, II, 11, 1932 (1981)<br></p>

<p>Applications (S)-Pulegone is the stereoisomer of (R)-Pulegone (P840140) which is a monoterpene, commonly found in the essential oils of Nepeta cataria (Catnip).<br>References Sonboli, A., et al.: Chem. Biodivers., 7, 1784 (2010), Ntalli, N., et al.: J. Agric. Food Chem., 58, 7856 (2010), Chun, M., et al.: Microchem. J., 95, 25 (2010)<br></p>

<p>Applications Fenclozic Acid is a a potent antiinflammatory agent with analgesic and antipyretic properties and is a human hepatotoxic drug.<br>References Hepworth, W., et. al.: Nature, 221, 582 (1969); Rodrigues, A.V.M., et. al.: Arch. Toxicol., 87, 1569 (2013)<br></p>

<p>Impurity Indomethacin EP Impurity B<br>Applications N-Deschlorobenzoyl Indomethacin (Indomethacin EP Impurity B) is a metabolite of Indomethacin.<br>References O'Brien, W., et al.: Clin. Pharmacol. Ther., 9, 94 (1968), Duggan, D., et al.: J. Pharmacol. Exp. Ther., 181, 563 (1972), Abourashed, E., et al.: Curr. Med. Chem., 6, 359 (1999), Chatterjee, P., et al.: J. Nat. Prod., 62, 761 (1999),<br></p>

<p>Applications 4-Formylbenzoic Acid Methyl Ester is a benzoic acid derivative with antioxidant activity.<br>References Conde, E. et al.: Food Chem., 114, 806 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Deoxy-D-arabino-hexonic Acid Calcium Salt has been shown to not play a major role in the initial hydrothermal decarboxylation of biomass.<br>References Luijkx, G.C.A., et. al.: Carbohyd. Res., 272, 191 (1995)<br></p>