Building Blocks

<p>Impurity Aripiprazole Diquinoline Butanediol Impurity (USP)<br>Applications An impurity found in the process for the preparation of Aripiprazole (A771000). Aripiprazole Diquinoline Butanediol Impurity (USP).<br>References Burris, K., et al.: J. Pharmacol. Exp. Ther., 302, 381 (2002), Harrison, T., et al.: Drugs, 64, 1715 (2004),<br></p>

<p>Applications Octadec-9-yne (CAS# 35365-59-4) is a useful research chemical compound.<br></p>

<p>Applications (2-Nitrophenyl)hydrazine (cas# 3034-19-3) is a useful research chemical.<br></p>

<p>Applications 3,6-Bis(hydroxymethyl)-2,5-piperazinedione is an intermediate in the synthesis of impurities of Cycloserine (C988800), an antibacterial agent.<br>References Shields, J. E., et al.: Biochem., 5, 1041 (1966); Hidy, P.H., et al.: J. Am. Chem. Soc., 77, 2345 (1955);<br></p>

<p>Applications Cystamine dihydrochloride is the dihydrochloride salt of Cystamine, a neuroprotective drug that works by inhibiting transglutaminase activity in the body. Cystamine has also exhibited suppressive effects against HIV replication in infected human cells.<br>References Bergamini, A., et al.: J. Clin. Invest., 93, 2251 (1994); Fox, J., et al.: J. Neuro., 91, 413 (2004); Jeitner, T., et al.: Biochem. Pharm., 69, 961 (2005)<br></p>

<p>Applications Bis(2-chloroethyl)-d8-amine HCl (CAS# 102092-04-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 10-NONADECANONE (cas# 504-57-4) is a useful research chemical.<br></p>

<p>Applications NN'-Bis(2-hydroxyethyl)urea (cas# 15438-70-7) is a useful research chemical.<br></p>

<p>Impurity Cyclophosphamide Impurity A<br>Applications A cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard. Cyclophosphamide Impurity A<br>References Colvin, M. et al.: Cancer Res., 36, 1121 (1976); Ludeman, S. et al.: Drug Metab Dispos., 20, 337 (1992); Ludeman, S.M. et al.: J. Pharmaceut. Sci., 84, 393 (1995); Yu, L. et al.: Drug Metab. Dispos., 24, 1254 (1996);<br></p>

<p>Applications Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014); Keaney, E.P., et al.: Bioorg. Med. Chem. Lett., 24, 3714 (2014)<br></p>

<p>Stability Moisture Sensitive<br>Applications Norcantharidin is a potential antitumor agent.<br></p>

<p>Applications 2-(carboxymethyldisulfanyl)acetic acid (cas# 505-73-7) is a useful research chemical.<br></p>

<p>Applications trans-2-Nonenal is an unsaturated aldehyde that is a product of fatty acid peroxidation (and also has a grassy, cucumber smell). trans-2-Nonenal is naturally found in mushrooms, coffee and is also a constituent of carrot root. It also exhibits insecticidal effects.<br>References Chamberlain, D., et al.: J. Chem. Ecol., 17, 615 (1991); Guerin, P. &amp; Ryan, M.: Experentia, 36, 1387 (1980); Parliment, T., et al.: J. Agr. Food Chem., 21, 485 (1973); Wood, W., et al.: Mycologia, No vol. given, 561 (1994)<br></p>

<p>Applications Cyclooctatetraene is used as a reactant in the synthesis of tricyclo[4.2.2.02,5]dec-9-ene-3,4,7,8-tetracarboxylic acid diimide, an antitumor drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vishnuvajjala, B.R., Cradock, J.C.: J. Pharm. Sci., 75, 301 (1986)<br></p>

<p>Applications N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alloisoleucine, is a building block used in the synthesis of Ecumicin, which is a the potent anti-mycobacterial cyclic depsipeptide natural product.<br>References Hawkins, P. et al.: Organic Letters, Vol. 20, P: 1019-1022 (2018)<br></p>

<p>Applications N-Nonanoylmorpholine (cas# 5299-64-9) is a useful research chemical.<br></p>

<p>Applications Nonanoyl Chloride is used in the synthesis of immunosuppressants involving 2-aminoethanols and aminopropane-1,2-diols. Also used in the synthesis of Vanilloids with antinociceptive and antiinflammatory compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kiuchi, M. et al.: J. Med. Chem., 43, 2946 (2000); Janusz, J. et al.: J. Med. Chem., 36, 2595 (1993);<br></p>