Building Blocks

<p>Applications (1R,5S,6R)-Ethyl 5-(Pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate is the enantiomer of Ethyl (3R,4S,5S)-4,5-Epoxy-3-(1-ethylpropoxy)cyclohex-1-ene-1-carboxylate (E917820), an intermediate of Oseltamivir.<br>References Clark, C., et al.: J. Med. Chem., 31, 831 (1988)<br></p>

<p>Applications 3-Ethyl-2,4-dimethyl-1H-pyrrole is a important diagnostic compound for pyrrole disorder or pyroluria, an abnormality in biochemistry resulting in overproduction of pyrrole molecules and resulting in improper hemoglobin synthesis.<br>References Walsh, W.J., et al.: Physiol. Behav., 82, 835 (2004); Inrvine, D.G., et al.: Clin. Chem., 24, 2069 (1978);<br></p>

<p>Applications Ethyl difluoroacetate<br></p>

<p>Applications α,α'-Dichloro-o-xylene is a useful building block, and has been used in the preparation of nanocomposite copper metal.<br>References Nejadshafiee, V.; et al.: Turkish Journal of Chemistry, 41, 700 (2017).<br></p>

<p>Applications Caffeic Acid analog potentially having anti-inflammatory effects.<br>References Gardana, C., et al.: J. Pharm. Biomed. Anal., 45, 390 (2007), Falcao, S., et al.: Anal. Bioanal. Chem., 396, 887 (2010),<br></p>

<p>Stability Light Sensitive<br>Applications Protected Caffeic Acid<br>References Kurata, A., et al.: J. Biotechnol., 148, 133 (2010), Buzzi, F., et al.: Eur. J. Med. Chem., 44, 4596 (2009), Xu, G., et al.: Arch. Pharm., Res., 32, 1215 (2009),<br></p>

<p>Applications Ethyl Diazoacetate is used in the synthesis of Arteludovicinolide A as well as pyrimidoazepine analogs as seritonin 5-HT2A/C receptor ligands for treatment of obesity. This compound contains solvent for added stability.<br> E0<br>References Yang, H. et al.: Eur. J. Med. Chem., 63, 558 (2013); Kreuzer, A. et al.: Org. Lett., 15, 3420 (2013);<br></p>

<p>Applications trans-Campestanyl Ferulate is used for synthesis of trans-feruloyl-β-sitostanol.<br>References Condo, A., et al.: J. Agric. Food Chem., 49, 4961 (2001);<br></p>

<p>Applications Reagent used in labelled pyrimidine and purine synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009),<br></p>

<p>Applications Ethyl Cinnamate, is used in the preparation of polymer-encapsulated osmonium used as a catalyst for the dihydroxylation of alkenes and preparation of a camptothecin intermediate, anticancer drug. Also used in the synthesis of substrate specific ERK1/2 inhibitors used to induce apoptosis and inhibit cell proliferation.<br>References Akiyama, R. et al.: RSC Adv., 2, 7456 (2012); Li, Q. et al.: Bioorg. Med. Chem. Lett., 19, 6042 (2009);<br></p>

<p>Applications Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative.<br>References Rask-Madsen, J., et al.: Eur. J. Clin.Invest., 13, 351 (1983), Minuz, P., et al.: Pharmacol. Res. Commun., 16, 875 (1984), Pindato, S., et al.: Anal. Profiles Drug Subs. Excip., 24, 1 (1996),<br></p>

<p>Applications An impurity of the anti-convulsant (S)-Pregabalin (P704790).<br>References Lin, S. et al.: J. Liq. Chrom. Rel. Technol., 19, 2699 (1996); Sripathi, S. et al.: ARKIVOC, 10, 266 (2010);<br></p>

<p>Impurity Loratadine EP Impurity H<br>Applications N-Carbethoxy-4-piperidone (Loratadine EP Impurity H) is used in the preparation of 3-hydrazinopyridazines as antihypertensive agents as well as γ-carboline derivatives as potential serotonergic agents. N-Carbethoxy-4-piperidone is also an impurity of Loratadine (L469575).<br>References Schenker, E. et al.: Arsneim.-Forsch., 29, 1835 (1979); El-Kader, A. et al.: Mans. J. Pharm. Sci., 6, 1 (1989); Albu, M. et al.: J. Liq. Chrom. Rel. Technol., 32, 2569 (2009);<br></p>

<p>Applications Ethyl 3-bromopropionate<br></p>

<p>Stability Corrosive<br>Applications Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, Li., et al.: Bioorg. Med. Chem., 18, 7948 (2010); Roberts, D.W., et al.: Chem Res. Toxicol., 23, 228 (2010);<br></p>

<p>Applications Hydrazine derivative.<br></p>