Building Blocks

<p>Applications Epolamine is a very useful synthetic intermediate. It is a reagent used to synthesize Diclofenac Epolamine (D436470) which is a diclofenac salt with greater water solubility and better cutaneous absorption properties than other commonly used forms of the drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Serafini, G., et al.: Clin. Drug Invest., 32, 41 (2012); Fini, A., et al.: Eur. J. Pharm. Biopharm., 38, 66 (1992)<br></p>

<p>Applications An impurity of the anti-convulsant (S)-Pregabalin (P704790).<br>References Lin, S. et al.: J. Liq. Chrom. Rel. Technol., 19, 2699 (1996); Sripathi, S. et al.: ARKIVOC, 10, 266 (2010);<br></p>

<p>Applications Isocyanobenzene is used in the study of the inhibition mechanism of reconstituted cytochrome p-450scc-linked monooxygenase system by antimycotic reagent and other inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kurokohchi K., et al.: J. Steroid Biochem. Mol. Biol., 42, 287 (1992)<br></p>

<p>Applications Alizarin is used widely as a prominent red dye for textile facbrics. Alizarin red is now used in biochemical assay to determine quantitatively by colorimetry, the presence of calcific deposition by cells of the osteogenic lineage. Alzarine derivatives was evaluated as new inhibitors of the HIV-1 reverse transcriptase associated DNA polymerase and RNase H. Alizarin was also shown to inhibit proliferation, tumor growth and suppress tumorigenesis in human osteosarcoma and breast cancer cell representative for bone metastasis. Dyes and metabolites.<br>References Yuan, H.S., et al.: Mycol., 3, 100 (2012); Esposito, F. et al.: FEBS. J., 278, 1444 (2011); Fotia, Caterina, J. Orthop. Rsch. 30, 1486 (2012);<br></p>

<p>Applications 5-Chloronaphthalene-1-sulfonyl Chloride (cas# 6291-07-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Bis(2-hydroxypropyl) Ether is commonly used as a plasticizer, an intermediate in industrial chemical reactions.<br>References Fasano, W.J., et al.: Toxicol. In. Vitro., 25, 1664 (2011); Ottavioli, J., et al.: Spectroscopy. Lett., 44, 221 (2011);<br></p>

<p>Applications One of the alkyl ethers with tert-Bu groups in their molecules which showed very poor biodegradability, tert-Bu Me ether (MTBE)  [1634-04-4] had no effect on the biodegradability of gasoline blended with it. Studies on the biodegradation of several alkyl ethers were carried out by measuring the O uptake rate in the presence of standard activated sludge as a source of microorganisms.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Siegemund, B., et al.: Acute Toxicity Data, 1, 200 (1992),<br></p>

<p>Applications Shows some anti-viral activity due to the adamantane structure. In addition it shows anti-microbial activity and cytotoxic application.<br>References Aigami, K. et al.: J. Med. Chem., 18, 713 (1975); Aigami, K. et al.: J. Pharm. Res., 4, 1407 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Diazolidinyl urea is an antimicrobial agent.<br></p>

<p>Applications Ethylmalonic Acid is used as a diagnostic agent used in the diagnosis of Ethylmalonic encephalopathy which is a rare autosomal recessive inborn error of metabolism.<br>References Baertling, F. et al.: Eur. J. Pediat., 173, 1719 (2014); Sudo, Y. et al.: Hu,am Genome Var., 1, 15016 (2014);<br></p>

<p>Applications 3-Methoxycatechol is used to prepare polyphenolic deoxybenzoins as potential antioxidants and tyrosinase inhibitors.<br>References Ng, L., et al.: Bioorg. Med. Chem., 17, 4360 (2009)<br></p>

<p>Applications phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate (cas# 1281055-79-5) is a useful research chemical.<br></p>

<p>Applications 2-Ethyl-2-methylpentanoic Acid is a derivative of 2,5-Dimethyl-2-ethylhexanoic Acid (D461540), used in biological studies to evaluate environmental chemicals for estrogenicity.<br>References Rabinowitz, J.R., et al.: Chem. Res. Toxicol.,22, 1594 (2009); Judson, R., et al.: Environ. Health Perspect, 117, 685 (2009)<br></p>

<p>Stability Moisture Sensitive<br>Applications Ethyl Malonyl Chloride is used as a reagent in the synthesis of novel thiadiazoloacrylamide analogs as inhibitors of dengue-2 virus NS2B/NS3 protease. Ethyl Malonyl Chloride is also used as a reagent in the synthesis of quinolone-benzylpiperidine derivatives as acetylcholinesterase inhibitors and antioxidant hybrids for Alzheimer disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, H., et al.: Bioorg. Med. Chem., 22, 6344 (2014); Pudlo, M., et al.: Bioorg. Med. Chem., 22, 2496 (2014)<br></p>