Building Blocks

Applications A novel utilization of aminophenone derivative in toxicology, for treating intoxications with cyanogenic toxic substances.
References Donoghue, N., et al.: Eur. J. Biochem., 60, 1 (1975), Chen, Y., et al.: J. Bacteriol., 170, 781 (1988),

Stability Hygroscopic
Applications A nucleotide base as immunostimulator agent.
References Allawi, H., et al.: Biochemistry, 36, 10581 (1997), Wilhelm, J., et al.: Chem. BioChem., 4, 1120 (2003),

Applications etramethylpyrazine is an anti-inflammatory compound isolated from the fermented food natto. Tetramethylpyrazine demonstrated in vivo nootropic activity in rats.
References Kao, T., et al.: Exp. Neurol., 247, 188 (2013); Wu, W., et al.: Behav. Brain Res., 253, 212 (2013)

Stability Moisture Sensitive
Applications 9-Fluorenylmethyl Chlorocarbonate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopamine (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rebane, R., et al.: J. Chromatograph. Anal. Technol. Biomed. Life. Sci., 904, 99 (2012); Brueckner, H., et al.: Amino. Acids., 42, 877 (2012);

Applications A fluorescent reagent used to evaluate peptides, pharmaceutical drugs and other bioactive compounds.
References Rudat, B. et al.: Eur. J. Med. Chem., 46, 4457 (2011); Michail, K. et al.: Int. J. Pharm. Pharmac. Sci., 3, 180 (2011); Walsh, M. et al.: J. Fluoresc., 21, 105 (2011);

Applications 2-(2-Nitrophenyl)malondialdehyde (cas# 53868-44-3) is a useful research chemical.

Applications Harmine is a natural β-carboline alkaloid and a CNS stimulant (1,2). Harmine has been shown to be a potent and selective inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) (3). DYRK1A is a potential therapeutic target for treating diabetes, Down Syndrome, and HIV (4).
References (1) DiStefano, S., et al.: J. Pharmacol. Exp. Ther., 174, 456 (1970)(2) Dos Santos, R. G. and Hallak, J. E. J Psychoactive Drugs. 5,1 (2016) (3) Atteya, R., et al.: Mech Ageing Dev. 6, S0047 (2016)(4) Bol, S. M., et al.: PLoS One. 6, e17190 (2011)

Applications 5-Hydroxymethyluracil (cas# 4433-40-3) is a compound useful in organic synthesis.

Applications Bis(2-butoxyethyl) 2-Hydroxyethyl Phosphate Triester is a metabolite of Tris(2-butyloxyethyl)phosphate (T875030), which is an organophosphate, that can be used in the preparation of flame retardant, such as viscose fiber.
References Wang, Y., et al.: Fangzhi Xuebao, 33, 16 (2012); Xiaoshan, L. et al.: Aquatic Toxicology, 114, 173 (2012);

Applications An intermediate in the manufacturing of pressor amines. The sulfate salt is used as topical vasoconstrictor.
References Zhang, L., et al.: Biochem. J., 340, 255 (1999), Miyazaki, M., et al.: J. Biol. Chem., 278, 33904 (2003), Li, C., et al.: Bioorg. Med. Chem. Lett., 19, 5214 (2009),

Applications Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors.
References Day, J. et al.: Chem. A Eur. J., 16, 2758 (2010); Sechi, M. et al.: Bioorg. Med. Chem., 17, 2925 (2009);

Applications (3-Azidopropyl)triphenylphosphonium Bromide (cas# 127611-39-6) is a compound useful in organic synthesis.

Applications 2'-Aminoacetophenone, is detected in the breath of Pseudomonas aeruginosa colonized cystic fibrosis patients. It is also present in various food products causing different off-flavors.
References Christoph, N. N., et al.: Advances Exp. Med. Bio., 467, 659 (1999); Scott, A. A., et al.: J. Breath Rese., 5(4), 046002 (2011);

Applications Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates.
References Canton, R., et al.: J. Clin. Microbiol., 40, 1237 (2002), Yu, E., et al.: Science, 300, 976 (2003), Chollet, R., et al.: Antimicrob. Agents Chemother., 48, 2518 (2004), Li, X., et al.: Drugs, 64, 159 (2004),

Applications Methyl 5-Aminopentanoate Hydrochloride is used as a reactant to synthesize several compounds with therapeutic potential.
References Larson, Peter, et al.: ACS Med. Chem. Let, 8(11), 1148-1152 (2017);Li, Yongtao, et al.: J. of Med. Chem., 61(7), 3166-3192 (2018);Lu, Yuzhi, et al.: ACS Med. Chem. Let., 7(12), 1185-1190 (2016)

Applications Occurs in unripe fruit and in young green leaves; has also been found in very young sugar beets.
References Lelieveld, J., et al.: Nature, 452, 737 (2008), da Silva, G., et al.: Environ. Sci. Technol., 44, 250 (2010),

Applications 3-(4-Hydroxyphenyl)propionic Acid Methyl Ester is a useful synthetic intermediate. It can be used to prepare potent and orally available G protein-coupled receptor 40 agonists as potential antidiabetic agents.
References Sasaki, S., et al.: J. Med. Chem., 54, 1365 (2011); Christiansen, E., et al.: ACS Med. Chem. Lett., 1, 345 (2010)

Applications 2,4,5-Trifluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize quinolone antibacterial agnts.
References Sanchez, J., et al.: J. Med. Chem., 31, 983 (1988); Tran, T., et al.: Bioorg. Med. Chem. Lett., 14, 4405 (2004)