Building Blocks

<p>The isoxazole ring of 3-(pyridin-4-yl)isoxazol-5-amine is stabilized by hydrogen bonds. The orientation of the pyridine ring and the two asymmetric carbon atoms result in a chiral center. The molecule has two possible structures. The result of this is a molecule that can be stabilized with one or the other configuration, depending on how it is synthesized.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Biphenyl-4-thiol is a biphenyl derivative that is used in the treatment of fatty acid oxidation disorders. It is a lipophilic molecule that accumulates in red blood cells and can be detected by surface-enhanced Raman spectroscopy. Biphenyl-4-thiol has been shown to interact with the lipid bilayer, which may be due to its ability to form monolayers on the surface of red blood cells. The dipole moment of biphenyl-4-thiol causes an accumulation of electrons on one side of the molecule, which leads to electrochemical impedance changes upon exposure to electromagnetic radiation. X-ray absorption studies have shown that biphenyl-4-thiol has good chemical stability, which may be due to its aromaticity.</p>

<p>4-Chloro-8-nitroquinazoline is a potent antiproliferative agent that binds to the FGFR3 receptor and inhibits the proliferation of bladder cancer cells. It also has potent activity against bladder cancer cells in culture and inhibits cell growth by binding to submicromolar concentrations of this protein. 4-Chloro-8-nitroquinazoline may be useful for the treatment of bladder cancer, which is a disease characterized by uncontrolled cell division. This drug can inhibit proliferation of bladder cancer cells by interfering with their ability to signal through FGFR3 receptors, thereby inhibiting the activation of downstream signaling pathways that regulate cell cycle progression.</p>

3-Ethynyl-1-azabicyclo[2.2.2]octan-3-ol is a potent inhibitor of farnesyl diphosphate synthase, an enzyme involved in the biosynthesis of cholesterol. It also has potent inhibitory activity against muscarinic acetylcholine receptors and antimuscarinic effects on the bladder. 3-Ethynyl-1-azabicyclo[2.2.2]octan-3-ol is rapidly absorbed from the gastrointestinal tract and catalyses the nonenzymatic conversion of low density lipoproteins (LDL) to oxidized LDL, which is then taken up by macrophages in the arterial wall where it promotes foam cell formation and atherosclerosis. This drug also inhibits cerebral function and has been shown to have antitumor properties in animal studies.

<p>2-Amino-5-acetylpyridine is a potent adenosine kinase inhibitor. It binds to the ATP site of the enzyme and inhibits the production of ATP, which is necessary for the normal functioning of cells. 2-Amino-5-acetylpyridine has been shown to be orally bioavailable in rat studies. In computational studies, it was found that analogues with a longer side chain may provide greater potency and oral bioavailability. Computational studies also revealed that 2-amino-5-acetylpyridine may have selectivity for adenosine over other substrates.</p>

<p>2-(Piperidin-2-yl)acetic acid (2-PA) is a coordination complex that binds to the l-tartaric acid ligand, which is an amide. This compound may be used to treat urinary infections and fatty alcohols. 2-PA has shown anticancer activity in vitro and in vivo against a wide range of cancer cells. 2-PA also inhibits the production of isoflavonoid, which is a plant hormone that has been shown to possess anticancer properties. It also has been shown to have anti-inflammatory effects and can inhibit lipase activity. This compound can be synthesized using organic solvents at temperatures between -20°C and 180°C.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold