Building Blocks

<p>Versatile small molecule scaffold</p>

3-(1-Pyrrolylmethyl)pyridine (3PMP) is a pyrrole that can be used as an electrocatalyst in polymerization reactions. The catalytic activity of 3PMP has been studied by electrochemical impedance spectroscopy and voltammetry. 3PMP is also a good electron donor because of its ability to form a stable radical cation at the electrode. This redox potential may be due to the presence of pyridine nitrogen, which is able to form strong hydrogen bonds with other molecules. 3PMP has also been shown to have good transport properties and can be used for copolymerization with other monomers, such as tetraphenylporphine, leading to an exponential increase in the number of polymer chains formed.

2-[(2,3-Dihydro-1H-inden-2-yl)amino]acetic acid is a non-peptide neurotransmitter that is synthesized by the LNTN cells in the rat brain. It has high concentrations in the central nervous system and it has been found to be an agonist at the NOP receptor. The drug is metabolized by hydrolytic enzymes, such as esterases and glucuronidases, which are present in high concentrations in the body. This compound may be used for diagnostic purposes with its profile of pressor activity and hypotensive effects.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Formyl-3-methoxybenzoic acid is a sulfamic acid derivative that has been used in the treatment of asthma. It is a prodrug that converts to its active form, methanesulfonic acid, by enzymatic transfer. The target product of this reaction is zafirlukast, which competitively blocks leukotrienes at the cysteinyl leukotriene receptor. Methanesulfonic acid acts as an inhibitor of hydrogen transfer and may also act as a proton ionophore in the lungs. 4-Formyl-3-methoxybenzoic acid can be synthesized on a large scale with chemical products that are readily available. This agent reacts with proline and protonates it.</p>

<p>Versatile small molecule scaffold</p>

<p>2-{[(2-Methoxybenzyl)oxy]methyl}oxirane is a monoclonal antibody that binds to the follicle-stimulating hormone receptor (FSHR) and blocks its activity. It has been shown to be effective in autotransplantation, which is a treatment for infertility in women. The antibody can be used as an anti-apoptotic agent and may have potential use as a cancer therapy. 2-{[(2-Methoxybenzyl)oxy]methyl}oxirane has shown promising results in vivo in mouse models of skin cancer, leukocytes, and murine melanoma. This drug also has the ability to inhibit the proliferation of tumor cells by inducing apoptosis through binding to annexin V.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

3-Amino-pentanoic acid hydrochloride is a glycine analog, which blocks the glycine receptor of the NMDA type and inhibits glutamate binding. 3-Amino-pentanoic acid hydrochloride has been shown to have synergistic interaction with aminooxyacetic acid, an inhibitor of the glycine transporter. This increases the concentration of glycine in the synapse and leads to an anticonvulsant effect. 3-Amino-pentanoic acid hydrochloride also interacts with γ-aminobutyric acid (GABA) receptors and taurine receptors, which may be due to its structural similarity to these compounds.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,6-Naphthyridin-1(2H)-one is a potent and selective inhibitor of the chemokine receptor CXCR4. It is a novel and innovative compound that has been shown to have neuropathic pain activity in animal models. This agent has also been shown to inhibit the growth of cancer cells in vitro. The substitution pattern on this molecule may be responsible for its binding affinity to CXCR4 receptors as well as its selectivity over other chemokine receptors. 2,6-Naphthyridin-1(2H)-one has been shown to be an antagonist of the chemokine receptor CXCR4, which may be beneficial for treatment of chronic inflammatory diseases or cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>