Building Blocks

2-(2,5-Dioxoimidazolidin-4-yl)ethane-1-sulfonamide is a crystalline solid that belongs to the class of imidazolidinediones. It has the chemical formula CHNOS and a molecular weight of 244.25 g/mol. The imidazolidinedione ring system is planar with an intramolecular hydrogen bonding pattern. This compound can be used as a precursor for the synthesis of homocysteine, which is involved in methionine metabolism. 2-(2,5-Dioxoimidazolidin-4-yl)ethane-1-sulfonamide has been shown to have antiinflammatory properties and can be used to treat conditions such as gout and hypercholesterolemia.

2-Methyl-1H-indole-4-carboxylic acid (2MICA) is a cyclic compound that is used in the synthesis of other compounds. It is obtained by reacting 2,3-dibromo-nitrobenzoic acid with sodium ethoxide in an alkaline solution. The yield of 2MICA can be increased by using catalytic acid anhydrides such as dimethyl sulphoxide or lactam. In the presence of reductive agents, 2MICA can be synthesized from the corresponding lactam or cyclised carboxylic acid. 2MICA reacts with sodium ethoxide to form a lactam and reduces 2-bromo-3-nitrobenzoic acid to yield 2MICA.

Versatile small molecule scaffold

3-Methyl-3,4-dihydro-1H-quinoxalin-2-one is a substrate for tyramine and homovanillic acid oxidases. It is used as a fluorogenic substrate for horseradish peroxidase. The fluorescence of 3-methyl-3,4-dihydro-1H-quinoxalin-2-one changes in response to the activity of the enzyme. This makes it possible to measure the enzyme activity of tyramine or homovanillic acid oxidases by measuring the intensity of the fluorescence. The stability of 3 methyl -3,4 dihydro -1H quinoxalin -2 one has been shown when it was incubated with horseradish peroxidase at 37 degrees Celsius for 20 hours.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Cyclohexylpropyl bromide is a chemical reagent that is used as an intermediate in the synthesis of various drugs. It yields a mixture of products with different structures and properties, including dopamine, aldehydes, and phthalic acid. 3-Cyclohexylpropyl bromide has been shown to have a combination effect on the spontaneous locomotor activity of rats treated with dopamine. This may be due to its ability to inhibit metallo-β-lactamase, an enzyme that inactivates antibiotics such as carbapenems.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Amino-N,N-diethylacetamide is a hydrolysing agent that is used in pest control. It has been shown to be effective against Triatoma infestans and Tunga penetrans, which are vectors for Chagas disease. 2-Amino-N,N-diethylacetamide hydrolyses proteins by cleaving the peptide bond in tripeptides. The ester hydrochloride form of this compound has also been shown to be an effective insecticide against mosquitoes. This pesticide can be formulated with other active ingredients such as nitrous oxide or isobutyl chloroformate for increased efficacy.

Methyl 2-cyclopropylacetate is a heterocyclic compound that has anticancer activity. It inhibits the production of inflammatory cytokines, such as IL-8, in mice with colitis. Methyl 2-cyclopropylacetate also has been shown to inhibit the binding of noradrenaline to its receptor in cell cultures and animals with bowel disease. This drug binds to 5-ht1a receptors and inhibits reuptake of serotonin. Methyl 2-cyclopropylacetate is metabolized by CYP2D6 and CYP3A4 enzymes, making it an inhibitor for these two enzymes. The methyl group can be substituted with ethyl formate or an alkynyl group, which are less reactive than nitro groups when exposed to nucleophiles.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold