Building Blocks

2'-Methyl-biphenyl-2-carboxylic acid is a diacyl peroxide that can be synthesized by the cyclization of benzene and triphenylene. It has been used in the synthesis of biphenyl-2-carboxylic acid.

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Methyl-2H-isoquinolin-1-one is an analog of a natural molecule that can be used to treat autoimmune diseases. It is a small molecule with antiviral and immunomodulatory properties. 3-Methyl-2H-isoquinolin-1-one inhibits the expression of genes involved in the inflammatory response, such as Caspase 9 and IL6, and stimulates the expression of genes involved in tissue repair, such as MMP3 and TIMP3. 3-Methyl-2H-isoquinolin-1-one also has antihepatitis effects by acting on viral replication and targeting virus particles for destruction. The drug blocks the synthesis of new virus particles, which reduces inflammation caused by chronic hepatitis B or C infection. 3MIIQ inhibits the production of DNA from RNA templates during mRNA translation by binding to RNA polymerase III to block transcriptional elongation. This inhibition prevents viral gene expression and replication, leading to cell

Versatile small molecule scaffold

1-Chloro-3-methyl-isoquinoline is a cytotoxic compound with potent anti-cancer activity. It exhibits cytotoxicity against cancer cell lines and alkylation of DNA, which may be due to its ability to bind to the colchicine binding site on the cancer cell. 1-Chloro-3-methyl-isoquinoline has been shown to exhibit low yields in synthesis, but these can be improved by using phthalidyl as an intermediate. The chlorination of 1-chloro-3-methyl isoquinoline leads to the production of a heterocycle that is subsequently decarboxylated.

Versatile small molecule scaffold

Methylene blue is a dye that has been used in the treatment of methemoglobinemia and as an antimalarial drug. It has also been used as a stain for microscope slides, as a reagent in biochemical experiments, and as a diagnostic agent. Methylene blue is a triethylamine salt of the methylene blue molecule, which consists of a benzothiazine ring system with two methylene groups attached to it. The compound can reversibly bind to the active site of most known enzymes that contain heme groups, such as hemoglobin, cytochrome c oxidase, catalase, and xanthine oxidase. This binding inhibits these enzymes' activity by preventing substrate access to the active site. This property makes methylene blue useful in biochemistry research for studying enzyme function and mechanisms.

1-Methyl-1,2,3,4-tetrahydro-2lambda~6~,1-benzothiazine-2,2,4-trione is a heterocyclic compound that contains a benzene ring and a heterocyclic ring. It has an asymmetric carbon atom with two different substituents (a hydrogen and a sulfonyl group). The carbonyl group is bonded to the sulfur atom of the sulfonyl group. The molecule also has two hydrogen bonds in its geometry. This molecule has a dimerized conformation and can be found as a dimerized crystal structure.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6,7-Dihydro-5H-benzo[7]annulene is a synthetic derivative of the naphthalene group of compounds. It has been shown to have antiestrogenic activity and was used as a lead compound in the development of a new class of pharmaceutical preparations for the treatment of endometriosis and prostate cancer. This compound binds to estrogen receptors and inhibits their transcriptional activity. 6,7-Dihydro-5H-benzo[7]annulene also inhibits cell proliferation by binding to DNA and preventing RNA synthesis.

1H-Pyrrole-2-carboxamide,N,N-dimethyl (1) is a chemical compound that belongs to the pyrrole class. It has been shown to be able to form intermolecular hydrogen bonds with its neighboring molecules, which is due to the presence of a carbonyl group and an amide group. The x-ray crystal structure of 1H-pyrrole-2-carboxamide,N,N-dimethyl (1) shows that it has all the properties necessary for a successful hydrogen bond donor: electron density in the vicinity of the carbonyl group and electron density in the vicinity of the amide group. These two groups are located on opposite sides of a planar pyrrole ring system. This configuration gives 1H-pyrrole-2-carboxamide,N,N-dimethyl (1) an axial geometry and makes it centrosymmetric. The dimers formed

Versatile small molecule scaffold

Versatile small molecule scaffold