Building Blocks

Versatile small molecule scaffold

5-(4-Fluorophenyl)-5-methylimidazolidine-2,4-dione is a hydantoin derivative. It has an acceptor group and a coplanar benzene ring with two carbonyl chains. The dihedral angle between the two carbonyl groups is about 180 degrees, and the hydrogen bonds are formed between the carbonyl groups and the hydrogen atoms of the benzene ring. This compound has one hydroxyl group and can be classified as an alpha type.

Bromofluoroacetamide is a halopyridine chemical compound that is used as an antibacterial agent. It has been shown to inhibit the growth of bacteria, such as Gram-positive and Gram-negative bacteria, by binding to their cell membranes and dissociating into bromide ions. This drug also has anticancer properties, which may be due to its ability to interfere with the cell cycle and DNA synthesis. Bromofluoroacetamide has two isomers: 2-bromo-N-2,2-difluoroacetamidobenzene (DFAA) and 2,4-dibromoacetanilide (DABA). DFAA is more potent than DABA against Gram-positive bacteria.

3,3,3-Trifluoropropane-1,2-diol is a model compound that is synthesized from the reaction of phosphorus pentachloride and ethanolamine in the presence of irradiation. The product is an alcohol with three hydroxyl groups, which can be used for different reactions. 3,3,3-Trifluoropropane-1,2-diol has an active hydrogen bond that can form a hydrogen bond with an amino acid or phosphate group in a protein. It also has a trifluoromethyl group that can react with other compounds and cause them to be more toxic than they would otherwise be. 3,3,3-Trifluoropropane-1,2-diol has been shown to react with glutamic acid in model studies to form a cyclic amine.

4-[(Trifluoromethyl)sulphonyl]phenol is a hydrogen peroxide-releasing molecule that has been shown to be a strong electron donor. It is used as a catalyst in organic synthesis and can also act as a photochromic agent. 4-[(Trifluoromethyl)sulphonyl]phenol has the ability to form radicals with electron-deficient molecules such as carboxylic acids, alcohols, and amines. This process is called nitrating and can lead to reduction reactions with indoline or other aromatic compounds. 4-[(Trifluoromethyl)sulphonyl]phenol can also reduce hydrogen peroxide by transferring electrons from its phenolic hydroxyl group to the peroxide molecule, which leads to the formation of water and oxygen gas.

1,3-Benzothiazole-2-sulfonamide is a synthetic inhibitor that has been shown to inhibit proteolytic activity. It also inhibits the expression of aromatic hydrocarbons and nitro compounds by reacting with hydroxyl groups. This drug is metabolized by the liver. 1,3-Benzothiazole-2-sulfonamide has been shown to have prognostic value in human serum, chloride and carbonic acid levels in patients with head injuries. It is also known to be a functional group that can be found in pharmacological agents such as nitro compounds.

2-Nitrobenzenesulphonyl fluoride is a synthetic chemical compound that has been shown to inhibit the activity of basic proteins. It binds to the hydroxyl group of lysine residues and prevents them from forming cross-links with other proteins. This inhibition leads to a conformational change in the protein, which results in its denaturation or destruction. 2-Nitrobenzenesulphonyl fluoride has shown an inhibitory effect on creatine kinase, a muscle enzyme that provides energy for muscle contraction and relaxation. It also affects the diameter of bladder cells and inhibits acid analysis by inhibiting gastric secretions.

2-Amino-4,4,4-trifluoro-3-hydroxybutanoic acid (2AHB) is a β-amino acid that is used in the treatment of various diseases. 2AHB has been shown to have antiviral activity against coronaviruses and anti-inflammatory effects in mice. This compound also has radioprotective properties and can be used for the prevention of radiation induced injury. 2AHB has been shown to induce apoptotic cell death in many cells, including cancer cells. It can be used for the treatment of inflammatory diseases such as arthritis and inflammatory bowel disease. 2AHB binds to metal ions such as iron and zinc, which are required for some enzymes involved in DNA synthesis, leading to inhibition of these enzymes. This prevents DNA replication, which can lead to cell death.

(1-Bromo-2,2,2-trifluoroethyl)benzene is a nonpolar compound that is used as the stationary phase in gas chromatography. It is a polar compound with a high boiling point and low volatility. The boiling point of this compound is between 158°C and 214°C and its melting point ranges from −179°C to −114°C. The molecular weight of (1-bromo-2,2,2-trifluoroethyl)benzene is 174.3 g/mol. This compound has the chemical formula C6H4BrF3 and contains 6 fluorine atoms. Fluorine atoms are polyfunctional, which means they have more than one reactive site on the molecule. As a result, this compound can be used as an adsorbent for organic compounds in the sorbent industry.

Phenprocoumon is a drug that belongs to the class of coumarin derivatives. It is used as an oral anticoagulant for the prevention and treatment of thrombosis or embolism in patients with atrial fibrillation, chronic deep venous thrombosis, or pulmonary embolism. Phenprocoumon prevents clot formation by inhibiting vitamin K-dependent factors necessary for blood coagulation. This drug may also be used to control bleeding in persons with hemophilia A or B. Phenprocoumon has been shown to decrease the rate of myocardial infarction (heart attack) and mortality rates in patients who have had a previous myocardial infarction. The mechanism by which phenprocoumon works is not well understood but it is known that this drug may interact with other drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs).

Versatile small molecule scaffold

Versatile small molecule scaffold

3,5-Dibromo-4-fluorotoluene is a white solid that is soluble in acetone, ethanol, and benzene. It is also an intermediate in the synthesis of benzoic acid, which can be used to produce ester or chloride derivatives. 3,5-Dibromo-4-fluorotoluene has been shown to be a precursor for the production of lithium adducts and intermediates. This compound reacts with lithium to form lithium bromide (LiBr) and lithium iodide (LiI). The reaction with chlorine forms 3,5-dichloro-4-fluorotoluene (3,5-DDFT). This latter compound can dimerize to form an n-propyl derivative.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Fluoro-3,5-dinitrobenzoic acid (2FDBA) is a fluorinated dinitrophenyl ester that is used in microwave-assisted organic synthesis. It can be used to synthesize glycosylated trichloroacetimidates with efficient and stereospecific methodology. 2FDBA is an acceptor for the electron-rich trichloroacetimidates, which undergoes glycosylation reactions at these positions. The reaction proceeds under acidic conditions, with nucleophilic and reactive properties that are suitable for the synthesis of oligosaccharides and disaccharides. The product has been shown to be stable in water at pH 6.0 and above, but not in basic solutions.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Bromobenzyl fluoride is a nucleophilic, efficient fluorinating agent. It can be used for the synthesis of aldehydes and hydroxides in the presence of sodium hydroxide. 2-Bromobenzyl fluoride is also an efficient reagent for the synthesis of fluorinated compounds.