Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Hydrazine is an organic compound with the chemical formula HN-NH2. Hydrazine is a colorless, water-soluble liquid with an extremely unpleasant odor. It has many industrial and agricultural uses, including in pharmaceutical preparations. Hydrazine reacts with acids to produce hydrogen gas and a salt plus water. It also undergoes reductive amination with ketones or aldehydes to give secondary amines.
Hydrazine is used as an intermediate in the production of agrochemicals, dyes, pharmaceuticals, explosives, and other chemicals. It is also used as a reducing agent for analytical chemistry purposes or as a reagent in organic synthesis.
Hydrazine can be found in small quantities in some plants such as potatoes and spinach where it acts as an acidity regulator that helps prevent the plants from wilting under high soil pH levels.END>>

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Benzyloxane-2,6-dione is a methyl ester that has been optimized for pharmacokinetic properties. It is an amide with a catalytic activity and has been shown to bind to phospholipids. This compound has been screened in high-throughput screening tests and has been validated by binding to brain tissue. The pharmacological effects of 4-Benzyloxane-2,6-dione have not yet been elucidated but it is believed that the compound may be able to inhibit the production of beta amyloid peptides in the brain, which are thought to play a role in Alzheimer's disease.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-bromo-2-methylpent-1-ene is an organic compound that belongs to the group of isopentenyl compounds. It is a synthetic compound that has been shown to be effective as an antimicrobial agent. 5-bromo-2-methylpent-1-ene has a copper complex which binds to the copper and diphosphate groups in bacterial DNA, preventing replication and transcription. This drug also inhibits the synthesis of proteins by binding to ribosomes, thereby inhibiting protein synthesis. The antimicrobial activity of 5-bromo-2-methylpent-1e is due to its ability to inhibit RNA synthesis and DNA synthesis in bacteria.

Versatile small molecule scaffold

Versatile small molecule scaffold

Nitrophenols, such as 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol (NPO), are a class of drugs that bind to the c1-6 alkyl receptor. This binding causes receptor desensitization and leads to the inhibition of the release of neurotransmitters such as acetylcholine, histamine, and serotonin. NPO is an excipient in some pharmaceuticals and may also be used for treatment of high blood pressure or damaged heart tissue. The carboxylic acid group on NPO can react with sodium ions to form a salt called sodium nitrophenolate. The residue from this reaction can be removed by adding a cationic polymer before use.

Versatile small molecule scaffold