Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Acetyl-2-hydroxybenzonitrile (5AHB) is a fluorophore that has been used as an exploratory reagent in photochemistry and fluorescence. This compound is a radical mechanism and belongs to the family of benzenes. The quantum yield for 5AHB has been measured at 1.4% in single molecule experiments and 4% in bulk experiments. The mechanistic studies have shown that it is a radiation sensitive compound with a short half life, which can be explained by its photolytic properties. 5AHB has also been shown to be an efficient photosensitizer, which can be used to generate singlet oxygen that can be used as an oxidizing agent or electron donor in photochemical reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tert-butyl 2-chloro-2-oxoacetate is a substrate analogue that has been shown to inhibit the activity of aminopeptidase (AP) and esterase (EST). These enzymes are important for the degradation of peptides in the urine. Tert-butyl 2-chloro-2-oxoacetate has also been shown to have antibacterial properties against uropathogenic E. coli. This analog interacts with substrate proteins, inhibiting their function, which leads to an increase in the concentration of substrates and an inhibition of bacterial growth. Tert-butyl 2-chloro-2-oxoacetate is an amide that can be used as a biomolecular probe for conformational studies and as an inhibitor for AP and EST.</p>

<p>5-Phenylpyridine-2-carbonitrile is a synthetic compound. It emits light when subjected to an electric field, and it can be used in intermolecular quantum efficiency measurements. 5-Phenylpyridine-2-carbonitrile has been shown to have a quantum efficiency of 0.72% in benzonitrile and picolinonitrile diodes at room temperature, which is lower than the quantum efficiency of phosphorescent materials such as ZnS:CuCl (0.87%). This may be due to the low energy required for the triplet state to emit light.</p>

<p>6-Phenylpyridine-2-carbonitrile is a nitrogenous organic compound that has been used as a ligand to bind metal ions. It is also an efficient aminating agent. 6-Phenylpyridine-2-carbonitrile binds to bidentate ligands such as imidazole, which leads to the formation of amides and nitriles. This product has been used in the synthesis of biomolecules with nitrogen, such as urea.</p>

<p>6-Phenylnicotinonitrile is a reactive moiety that is generated from the reaction of an aryl halide and boronic acid. The 6-phenyl group can be used to form new carbon-carbon bonds in the synthesis of heteroaromatic compounds. This compound can also be recycled after use by reacting it with a boronic acid, which creates another reactive moiety. This recycling process has been shown to increase the efficiency of this chemical reaction.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Diethylamino)-2,2-dimethyl-propan-1-ol is a psychoactive substance that belongs to the group of phenethylamines. It is structurally related to the precursor molecule 2,5-dihydroxyphenethylamine (or dopamine). 3-(Diethylamino)-2,2-dimethyl-propan-1-ol has been shown to inhibit cytochrome P450 2C19 and metabolize into glucuronidated metabolites through CYP3A4 and other isoforms. This metabolite is excreted in human urine as a result of its metabolism by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl N-(3-methylphenyl)carbamate is a methylating agent that can be used to modify the epigenome. It is an inhibitor of histone lysine demethylases, which are enzymes that remove methyl groups from the amino acid lysine on histones. Methyl N-(3-methylphenyl)carbamate can also inhibit DNA replication and actin filament formation. This drug has been shown to have a clastogenic effect in mammalian cells and is also an inhibitor of effector proteins.</p>

<p>Versatile small molecule scaffold</p>