Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Methyl 6-methoxypyridine-2-carboxylate is an additive that can be used in the alkaline hydrolysis of esters. The pyridine nitrogen atom has a substituent effect on the methyl group, as it is electron donating and inductive. Substituent effects are seen when there are different atoms or groups attached to the same carbon atom. Methyl 6-methoxypyridine-2-carboxylate reacts with nucleophiles such as water, alcohols, amines, thiols, and acids to form esters and amides. These reactions are promoted by an acidic environment. The analogous reaction of methyl 6-methoxypyridine-2-carboxylate is its reaction with ammonia to form an amide.

<p>2,2-Diethylbutanal is a chemical that is used as an antineoplastic drug. It has been shown to have affinity for the mineral sulfide and oxidizers. 2,2-Diethylbutanal has also been shown to be a long-term maternal toxicant in animals, with effects on the fetus and newborns. It has also been shown to cause problems for infants by reducing their serum levels of thyroxine and triiodothyronine (thyroid hormones). This chemical causes genetic mutations in isolates of organisms such as E coli and S cerevisiae. 2,2-Diethylbutanal may have adverse effects on the conformation of proteins or interfere with protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5,5-Dimethyl-1,3-diazinane-2,4-dione is a hydrophobic molecule that regulates gene expression. It binds to the transcription factor TFEB and inhibits its activity. 5,5-Dimethyl-1,3-diazinane-2,4-dione also interacts with the transcription factor E2F and inhibits its activity. This agent is able to increase erythroid differentiation and inhibit hematopoietic differentiation. 5,5-Dimethyl-1,3-diazinane-2,4-dione has been shown to activate apoptosis by binding to DNA and inhibiting transcription of genes necessary for cell division. The affinity of this agent for DNA may be due to methyl groups on its structure.</p>

<p>Versatile small molecule scaffold</p>

<p>Ethylhexyl triazone Related Compound A is a compound that inhibits the production of melanin. It is used as an ingredient in sunscreens to protect against ultraviolet radiation. It has been shown to be a potent UVB filter with good photostability, and has been shown to be effective against both erythema and skin cancer in vivo. The analytical method for this compound is based on HPLC separation followed by UV detection at 254 nm. The validation study has been conducted using animals and the recoveries were found to be good across all levels of the test samples.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Benzoyl-2-methyl-1H-indole is an isomer of tetrahydrocarbazole. It has a high yield and optical purity. 3-Benzoyl-2-methyl-1H indole can be synthesized from β-unsaturated aldehydes, such as 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2yl)-3,5,6,-trimethylphenol. The compound has been shown to react with alkali metals to form a salt in the presence of dehydrogenative conditions. This reaction proceeds via an iminium intermediate that reacts with the metal salt to produce the product. 3BzIMeI can also react with alcohols or amines in the presence of heterocycles such as mesitylene to form substituted benzimidazoles.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>