Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Benzyl-1H-indole is a chemical compound that belongs to the class of dihydroisoquinolines. This drug has shown anti-HIV activity in vitro and in vivo. It has been tested for its ability to inhibit HIV replication and protein–protein interaction with human immunodeficiency virus type 1 (HIV-1) proteins. 4-Benzyl-1H-indole inhibits the growth of HIV by binding to the gp41 coiled coil, thereby preventing the conformational change necessary for fusion with host cells. The clinical use of this compound is limited due to its low solubility in water and poor oral bioavailability.</p>

<p>1H,4H,5H,6H,7H,8H-Pyrrolo[3,2-c]azepine is a tranquilizer that is chemically related to piperazine. It has no analgesic properties and is used as a tranquilizer.</p>

<p>4-Hydroxy-4-methyl-pent-2-ynoic acid is an organic compound with the formula CH(CH)COH. It is a methyl ester of propiolic acid. 4-Hydroxy-4-methyl-pent-2-ynoic acid can be synthesized from propiolic acid by reacting it with copper chloride and iodides in the presence of a catalytic amount of concentrated sulfuric acid. This reaction affords the methyl ester in high yield. The synthesis of 4-hydroxypropionic acid is analogous to that of acrylic acid, which also yields a methyl ester on chlorination. 4HMP has been used as an intermediate in the production of vitamin A by carbonylation, and as a precursor to propionic acid and its derivatives. 4HMP can also be used as an intermediate for making other chemicals such as dyes, pharmaceuticals, and polymers.</p>

Oxalic acid tert-butyl ester ethyl ester is an organic compound that is a byproduct of the production of methyl acetate. It has been shown to have antitumor and anti-inflammatory effects in animal studies. Oxalic acid tert-butyl ester ethyl ester contains a 7-chloro group, which is also present in deoxyharringtonine. The latter drug has been used to treat tumours and inflammatory conditions. In addition, oxalic acid tert-butyl ester ethyl ester can be converted into cephalotaxine (a natural alkaloid), which has been shown to be effective against cancer cells and inflammation.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2-Ethynyl-1H-indole is a synthetic nucleoside analog of the anti-viral drug acyclovir. It is an activated prodrug that is hydrolyzed by esterases to its active form, which inhibits viral polymerase and thus prevents the synthesis of new viral DNA. 2-Ethynyl-1H-indole also has been shown to have inhibitory effects on chronic bronchitis and emphysema, as well as demonstrating cytotoxic activity in vitro. The enantiomers of 2-ethynyl-1H indole have different pharmacological activities. The (R)-enantiomer is more potent than the (S)-enantiomer in inhibiting erythrocyte coagulation and platelet aggregation in vitro.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Hydroxy-N-(2-hydroxyethyl)benzamide (4OHEBA) is a natural product that belongs to the class of phenolic compounds. It is found in macroalgae and has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. 4OHEBA has also been shown to have chemical diversity and studies show that it can be used in preservative systems.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold