Building Blocks

<p>Versatile small molecule scaffold</p>

<p>1-(4-Fluorophenyl)prop-2-en-1-one is a chalcone that has been shown to have anticancer activity. It has been shown to stabilize the response elements of the transcriptional regulatory protein NF-κB and induce apoptosis in colorectal adenocarcinoma cells. This compound is also able to inhibit cancer growth by inhibiting tumor angiogenesis and metastasis. 1-(4-Fluorophenyl)prop-2-en-1-one binds to DNA, preventing transcription and replication, which leads to cell death. 1-(4-Fluorophenyl)prop-2-en-1-one has also been found to bind withaferin A, a molecule that has been shown to have anticancer activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,5-Dichloro-3,4-dinitrothiophene is a crystalline solid with a tetragonal crystal system. It has been shown to form with yields of up to 45%, depending on the solvent. The crystal structure has been determined by X-ray crystallography and it was found to be monoclinic with nitro groups interacting in a manner analogous to nitro groups. Nitration of 2,5-dichloro-3,4-dinitrothiophene has been shown to produce 2,5-dichloro-3,4-dinitrobenzene and 2,5-dichloro-3,4-dinitrophenylhydrazine.</p>

<p>N-Methyl-3-indoleglyoxylic acid 97 is a potent and selective inhibitor of protein kinases, including the mitogen activated protein kinase (MAPK) family. It has been shown to inhibit proliferation of cells in vitro. In addition, N-Methyl-3-indoleglyoxylic acid 97 inhibits the activation of MAPK in response to stress or cytokine stimulation. This agent has been shown to be selective for different isotypes of protein kinases and displays good selectivity for inhibition of the enzyme activity.</p>

<p>3,5-Bis(propan-2-yl)phenol is an organic compound that has the chemical formula C8H12O. 3,5-Bis(propan-2-yl)phenol can be synthesized from benzene and eugenol by reacting them with a strong base in a high yield. The product is an aromatic ether with a phenyl group. 3,5-Bis(propan-2-yl)phenol is toxic to artemia at concentrations of 2%. It also reacts with triisopropylbenzene to form carvacrol.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

1-(4-Hydroxyphenyl)imidazolidine-2,4-dione is a liquid at room temperature and pressure. It has a high yield of up to 99% and can be used in the production of styrene. The reaction time for this compound is about one hour. 1-(4-Hydroxyphenyl)imidazolidine-2,4-dione catalyses the conversion of styrene to divinylbenzene by reacting with water and base. This compound can also catalyse the conversion of hydantoin to dione when heated with an acid catalyst.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

2,6-Dichloropyrimidine-4-carbonyl chloride is a chemical compound that is used as an intermediate in the synthesis of different drugs. It is also used as an intermediate for the synthesis of 2,6-dichloropyrimidines. This compound is a colorless liquid with a strong odor of chloroform.

<p>Versatile small molecule scaffold</p>

<p>Octanoic acid, 8-bromo-, methyl ester is a histone deacetylase (HDAC) inhibitor that belongs to the class of fatty esters. It has been shown to inhibit cancer cell proliferation and induce cell apoptosis in MDA-MB-231 cells by inhibiting HDAC activity. This drug also has inhibitory activities against cyclin D1 and Bcl-2 expression, which are two proteins that regulate the cell cycle. Octanoic acid, 8-bromo-, methyl ester inhibits HDAC activity by forming an amide bond with the catalytic subunit of the enzyme. This inhibition can be reversed by an aziridine in vitro. Octanoic acid, 8-bromo-, methyl ester also possesses a carbonyl group and functional groups that make it a powerful inhibitor of HDACs.</p>

<p>1-(2-Sulfanylphenyl)ethan-1-one is an activating compound that has been shown to inhibit the growth of cancer cells. It has a strong inhibitory effect on malonic acid and epidermal growth factor, which are factors that stimulate cell proliferation. 1-(2-Sulfanylphenyl)ethan-1-one also inhibits the growth of tumor cells by inhibiting the synthesis of tissue extract and anticancer activity. The compound has been shown to have an inhibitory effect on skin cells and epidermal growth, as well as reducing fatty acids in tissues and sodium sulfide in blood plasma.</p>

<p>Versatile small molecule scaffold</p>