Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Cyclopentylpentanoic acid is a carboxylic acid that is produced by the condensation of two molecules of acetaldehyde. It has been shown to have antibacterial activities against Pseudomonas aeruginosa and Aeruginosa and has been used to treat bacterial infections in animals. Cyclopentylpentanoic acid also inhibits virulence factors, such as the production of exotoxins, proteases, and hemolysin, which are enzymes that destroy red blood cells. This compound also inhibits the growth of A. baumannii through sensing mechanisms mediated by an unknown factor.

Versatile small molecule scaffold

2-Amino-N,3-diphenylpropanamide is a chiral compound that can be synthesized from 2-propanol and amide. It has two moieties, which are the amide and the protonated amino group. The amide moiety is a chiral center because it has four different substituents. The experimental thermodynamic experiments show that the enantiomer with the R configuration has higher energy than the one with the S configuration. This is due to its high steric hindrance and its electron donating property.

2-Hydroxy-4-(phenylmethoxy)benzoic Acid Methyl Ester is a benzene derivative that inhibits the binding of xanthones to the benzene ring in a variety of ways. This compound is formed by reacting phenol with methyl benzoate in the presence of acid and heat. The low energy ligand inhibits the binding of xanthones to benzene by forming hydrogen bonds, covalent bonds, or van der Waals forces with the anion. 2-Hydroxy-4-(phenylmethoxy)benzoic acid methyl ester has shown anti-inflammatory properties, which may be due to its ability to inhibit leukocyte adhesion at inflammatory sites.

2-[(2-Nitrophenyl)amino]acetic acid (2NPA) is a selective antagonist with high affinity for the acetylcholine receptor. It has been shown to inhibit ionic currents in Xenopus oocytes expressing α-subunits of the nicotinic acetylcholine receptor. The compound binds to the site on the receptor that is normally occupied by acetylcholine and prevents it from binding to its normal binding site, thereby inhibiting functional activity. 2NPA was found to be a potent inhibitor of acetylcholine release in rat brain synaptosomes and inhibited acetylcholinesterase activity. 2NPA also inhibits cholinergic neurotransmission in the hippocampus, which may be due to its ability to block nicotinic receptors.