Building Blocks

Versatile small molecule scaffold

N-butyl methanesulfonate is a genotoxic agent that inhibits the growth of bacteria by binding to the DNA. N-butyl methanesulfonate is effective against typhimurium and has shown carcinogenic effects in hamster cells. N-butyl methanesulfonate is also capable of inhibiting quinoline derivatives, which are carcinogens that are found in tobacco smoke. This chemical can be used as a natural compound for the treatment of diabetic neuropathy and cryptococcus neoformans. It may also be used as an antiviral agent for the treatment of influenza virus.

<p>Chromane-2-carboxylic acid is an amide with a hydroxy group that has inhibitory effects on alkoxyphenols. It has been shown to have the ability to inhibit the growth of cancer cells in mammalian tissue and has been used in synthesizing nitro compounds. Chromane-2-carboxylic acid also inhibits matrix metalloproteinases, which are enzymes that break down proteins in the extracellular matrix and are associated with tumor invasion and metastasis. This compound also has radical scavenging activities, which may be due to its ability to form hydrogen bonds or intramolecular hydrogen bonds with aromatic hydrocarbons or fatty acids.</p>

<p>Bromo-PEG4-azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromo-PEG4-azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

GSK'547 is a small molecule that can interact with the ferroptosis pathway, which is involved in both acute and chronic kidney injury. GSK'547 has been shown to inhibit ischemia reperfusion-induced renal dysfunction by suppressing inflammation and oxidative stress. GSK'547 also inhibits cancer cell proliferation and acts as an anti-inflammatory agent. In addition, GSK'547 has been shown to be beneficial for treating tuberculosis infections and cavity diseases. The mechanism of action of GSK'547 involves inhibiting bacterial cell wall synthesis by binding to the beta-subunit of DNA gyrase. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division.

Versatile small molecule scaffold

1-Bromo-4-isobutylbenzene is a ketone that can be synthesized by the reaction of benzene with acetonitrile in the presence of a catalytic amount of oxone. The synthesis is an example of an arylation, which is the addition of an aromatic group to another molecule. It has been shown experimentally that 1-bromo-4-isobutylbenzene undergoes a transition from the x-ray structure analysis to the crystal x-ray structure when dissolved in acetonitrile and heated to 100°C. The final product is then purified by recrystallization with ethylene as a solvent.

2,2-Dipropylpentanoic acid is a white crystalline solid with a melting point of -51°C. It has a hydroxyl group and an ester linkage. The chemical formula is CH3(CH2)3COOC3H7. It has a molecular weight of 182.27 g/mol and a density of 1.071 g/cm3. It is soluble in organic solvents such as chloroform, ether, benzene, acetone, and carbon tetrachloride but insoluble in water. 2,2-Dipropylpentanoic acid can be used as a catalyst for the synthesis of polymers from monocarboxylic acids and chloride or magnesium halides. This compound also has antidepressant activity by inhibiting the reuptake of serotonin from the synapse into the presynaptic neuron.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Glycidyltrimethylammonium chloride is a quaternary ammonium compound that has been widely used as a disinfectant and in wastewater treatment. It is mainly used to kill bacteria and viruses, although it can also be used to remove hazardous material from water. Glycidyltrimethylammonium chloride has the ability to inhibit bacterial growth by causing cell membrane damage. This compound is also able to inhibit the synthesis of DNA, RNA, and protein in cells by binding to their respective building blocks. In addition, glycidyltrimethylammonium chloride has cytotoxic effects on human cells and significantly inhibits the replication of oral pathogens.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Methyl 2-chloro-5-iodonicotinate is a basic and yields a radioligand for use in imaging studies. It is used as a specific activity and solid-phase extraction. Methyl 2-chloro-5-iodonicotinate has been shown to be effective for radiolabeling studies of the brain following intravenous administration.</p>

Tris(2-cyanoethyl)phosphine (TCEP) is a metal carbonyl compound that has been used as a reagent in organic chemistry. TCEP is an amphoteric molecule that can react with both acids and bases, and is stable in the pH range of 5 to 9. It has been shown to have anti-inflammatory properties by inhibiting neutrophil migration. TCEP also has biological properties, such as its ability to inhibit the growth of Cryptococcus neoformans. TCEP binds to the mitochondrial membrane potential, which prevents proton leakage through the membrane and inhibits oxidative phosphorylation. TCEP binds strongly to minerals such as sodium salts, which can be used to isolate this molecule from reaction solutions. TCEP can be obtained by laser ablation or X-ray crystallography techniques.

<p>1-(4-Nitrophenyl)butane-1,3-dione is a tautomer of 1,4-naphthoquinone. This compound has been reported to have an optical rotation of [alpha]D=+14.2° (C=1 in methanol). The triflate and carbonyl groups are involved in hydrogen bonding with each other. The hydrogen bond is a weak interaction that only occurs between polar molecules. This compound also has an x-ray crystal structure, which can be determined by diffraction studies. It is possible to synthesize this molecule from 1,4-naphthoquinone and butane-1,3-dione or by photolysis of 1-(4-nitrophenyl)-2,5-dioxopentanoic acid. In addition to its optical properties, the intramolecular hydrogen bonds give this molecule interesting optical properties.</p>

Versatile small molecule scaffold