Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Quinoline-5-carbonitrile is a cyanide compound that can be used in the synthesis of heterocyclic compounds. The reaction between quinoline and 5-cyanovaleric acid produces 6-nitroquinoline, which is then converted to dimethyl sulfoxide by alcoholysis. This reaction product can then be used to synthesize an amide or nucleophile. Quinoline-5-carbonitrile reacts with potassium in the presence of bifunctional hydrazide to produce a cyanide ion, which can be hydrolyzed by an acid to release hydrogen cyanide gas. This experiment has been shown as a model for reactions involving cyano compounds.</p>

<p>1H,5H,6H,10Bh-Pyrazolo[1,5-c]quinazoline-5-thione is a heterocyclic compound composed of a benzene ring fused to a thiazole. It has been shown to react with thiophosgene in the presence of sodium borohydride and hydrazine to form the corresponding alkylated product. The reaction proceeds via an analogous mechanism. 1H,5H,6H,10Bh-Pyrazolo[1,5-c]quinazoline-5-thione also reacts with quinoline in the presence of acylation agents such as sulfonyl chlorides or acyl chlorides to form the corresponding ester. This compound can be used in alkali fission reactions that are analogous to hydrogen/deuterium exchange reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-(3-Fluorophenyl)-1,3,4-thiadiazol-2-amine is a white crystalline solid that is soluble in water. It reacts with hydrogen chloride to form 5-(3-chlorophenyl)-1,3,4-thiadiazol-2-amine and 5-(3-fluorobenzene)-1,3,4-thiadiazol-2-amine. The two dimers are centrosymmetric.</p>

<p>4-(5-Amino-[1,3,4]thiadiazol-2-yl)-phenol is a fluorescent probe that has been shown to be active against the transcription-polymerase chain of various plant viruses. It is also capable of inhibiting the replication of human immunodeficiency virus type 1 (HIV-1) and murine leukemia virus (MLV). 4-(5-Amino-[1,3,4]thiadiazol-2-yl)-phenol has been used to detect signal in living cells and tissues by fluorescence microscopy. This probe can also be used to detect protein ubiquitination and proteasomal degradation in a variety of organisms, including humans and mice.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Isopropyl 2-pyridyl ketone is an oxime that can be obtained from the reaction of pyridine and acetone. This compound is known for its diastereoselectivity, which is the preference of one stereoisomer over another. Isopropyl 2-pyridyl ketone has been shown to react with ammonium salts to form quaternary salt. The quaternary salt can then react with amines to form optically active products. Isopropyl 2-pyridyl ketone also reacts with hydrocarbons to form cyclic compounds.</p>

<p>1,2-Bis(pyridin-2-yl)ethan-1-one is a ligand that has an enolate form. It is a ferromagnetic compound with a solvothermal synthesis and trinuclear crystal structure. This ligand can be used as a catalyst in organic reactions and as a magnet to study magnetic properties.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-4-[(dimethylcarbamoyl)amino]benzoic acid is an anticancer agent that inhibits the growth of cancer cells by inhibiting the enzyme catalysis that is required for the synthesis of DNA. This drug is a synthetic compound with an active methylene group and an ester hydrochloride group. 2-Chloro-4-[(dimethylcarbamoyl)amino]benzoic acid also has a hydroxy group, which can be activated by enzymes such as enamine to form a reactive methylene, which reacts with other molecules to form reaction products. The mechanism of 2-chloro-4-[(dimethylcarbamoyl)amino]benzoic acid is similar to that of other anticancer drugs such as amine and amide.</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 6-hydroxy-1,3-benzothiazole-2-carboxylate (EHTBC) is a heterocyclic compound that belongs to the class of fluorinated benzothiazoles. It is used in analytical chemistry as a fluorescent probe for detection of ammonium ions. The fluorescence intensity of EHTBC is proportional to the concentration of ammonium ion and can be detected by a spectrophotometer with an excitation wavelength at 360 nm and emission wavelength at 450 nm. The detection time is typically less than 30 seconds. EHTBC has also been shown to have analytical applications in detecting fluoride ion and other halide ions in water samples. Fluoride ions react with EHTBC to form the fluorescent product ethyl 2-[6-(diethylamino)hexyloxy]benzoate, which can be detected by a fluorimeter with an excitation wavelength at 365 nm and emission wavelength at 480 nm.</p>

<p>2,3-Dihydro-1H-indole-1-carboximidamide is a heterocyclic compound that features a 6alkyl, nitro or heteroaromatic ring. It is an intermediate for pharmaceutical formulations and it has been shown to be active against various bacterial strains. 2,3-Dihydro-1H-indole-1-carboximidamide also has nitrogen and halogen atoms, as well as heteroatoms such as oxygen, sulfur and phosphorus. It can have a 6membered or a 5membered ring with one or two heteroatoms.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Chlorothiophene-2-carboxylic acid is a chemical compound that belongs to the group of carboxylic acids. The synthesis of this compound is regioselective, which means that it can be synthesized in only one possible stereoisomer. 4-Chlorothiophene-2-carboxylic acid is used as an intermediate for pharmaceutical products and as a medicament, which has been shown to have trackable properties. This compound has also been shown to inhibit the interaction between anions and cations, which may lead to the development of new drugs.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Allylmethanesulfonamide is a benzamide that has been shown to react with carboxylic acids and amides by an analogous reaction. It is a precursor in the production of other drugs. It can be used for the synthesis of benzoic acid and its derivatives, such as sulfanilamide. N-Allylmethanesulfonamide can also be used to produce o-phenylenediamine, which is used in the manufacture of dyes. This compound can also be used to synthesize oximes, which are precursors to nitro compounds. N-Allylmethanesulfonamide undergoes halogenation at the sulfur atom and can be oxidized at the benzylic position.</p>

<p>Versatile small molecule scaffold</p>

<p>N-(4-Nitrobenzoyl)-beta-alanine is a synthetic compound that can be used for the treatment of inflammatory bowel disease. This drug is synthesized by reacting 4-nitrobenzoyl chloride with beta-alanine in an organic solvent such as ethyl acetate or cyclohexanol. The reaction mixture is then filtered and crystallized to yield the desired product. The synthesis of this compound takes place at room temperature, and the reaction time can be varied depending on the desired rate of synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>(2S,3S)-2-Hydroxy-3-methylpentanoic acid (HMP) is an antimicrobial agent that functions by binding to metal ions in the bacterial cell wall and inhibiting their uptake. HMP also has a beneficial effect on insulin sensitivity. It has been shown that HMP binds to the amino acid lysine residues of proteins and inhibits protein degradation by corynebacterium glutamicum. This compound can be found in food products such as cheese and yogurt, but it is not known if it occurs naturally or is added during processing. The metabolic profile of this compound has been studied in humans and rats and it has been shown to have a wide range of effects on fatty acids and microbial metabolism. The molecular weight of HMP is 180.17 g/mol, with a melting point of 55°C. The chemical formula for HMP is C4H8O3. This molecule has two chiral centers, both at the carbon</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Amino-4-propoxybenzoic acid is an ophthalmic drug that belongs to the group of anesthetics. It is used as a local anesthetic in the eye. 3-Amino-4-propoxybenzoic acid is synthesized by the reaction of 2,6-dichlorobenzoyl chloride and 4-(methoxycarbonyl)phenylacetic acid. This reaction solution contains impurities that are related to the process such as chlorinated hydrocarbons, which can be identified by chromatographic analyses. The molecular weight for 3-amino-4-propoxybenzoic acid is 169.3 g/mol.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Cyclopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione is a non-polar molecule that has been shown to have adsorption properties. It is an analogue of uracil and 6-methyluracil and can be used in the synthesis of thymine. The adsorption property of 5-cyclopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione can be analyzed using chromatographic techniques. 5CPD is also a substituted pyrimidine which can be used in the synthesis of cytosine and molecules with similar structures.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Benzylpiperazin-2-one is a derivative of isoxazolidine. It is an amination reaction product that has been shown to have a profile of inhibition against phagocytic cells. 1-Benzylpiperazin-2-one has the ability to inhibit uptake and modification of drugs by inhibiting transport into the cell, which may be due to its antagonistic effects on halides and thp-1 cells. 1-Benzylpiperazin-2-one can also inhibit reuptake by blocking the transporter in presynaptic neurons, thereby preventing neurotransmitters from being recycled back into the neuron. The drug may also have antidepressant properties because it blocks reuptake of serotonin and dopamine in synapses.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-tert-butyl-3-nitrobenzoic acid is an inorganic compound that has been used as a semiconductor material. It is a programmable material that can be fabricated to have properties that can be changed by exposing it to radiation, such as electron beams or x-rays. 4-tert-butyl-3-nitrobenzoic acid has been studied for use in fabricating solar cells, transistors, and diodes. The compound has shown high growth rates and functionalities when it is exposed to silver ions or germanium. The ligands of the compound have also been optimized for use with organic materials.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole is a nitroheterocyclic compound that belongs to the group of antimicrobial agents. It has been shown to be active against Leishmania and is used in combination therapy with melarsoprol and sesquiterpene lactones. 1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole inhibits the growth of bacteria by interfering with their electron transport system, which may lead to cell death. 1-Methyl-2-[(4-(methylthio)phenoxy)methyl]-5nitro -1H imidazole also has pharmacokinetic properties that are similar to those of fexinidazole, which makes it suitable as an experimental model for this drug's effects on humans.</p>

<p>N-Heptylformamide is a growth factor and an energy metabolism regulator that has been shown to affect platelet aggregation and human serum. It has been studied as a potential treatment for carcinoma cell lines in vitro assays. This compound also has neurotrophic effects, meaning it stimulates the growth and differentiation of nerve cells. N-Heptylformamide may be useful as a treatment for melanoma, since it induces the production of melanoma antigen by polymerase chain reaction. In vitro assays have shown that N-heptylformamide binds to protein kinase C (PKC) and inhibits PKC activity by preventing the phosphorylation of proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Bromo-4-cyclopentylbenzene (1-BCPB) is a chlorinated aromatic compound that can be synthesized by reacting 1-bromo-4-chlorobenzene and cyclopentylmagnesium bromide. The reaction sequence begins with the addition of hydrochloric acid to the first reactant, followed by magnesium chloride and ether. The mixture is heated to produce a liquid solution of ethylhexyloxy pyridine, which reacts with the second reactant in a sequence that leads to the desired product. 1-BCPB is used as an intermediate in organic synthesis. It has been shown to have moderate interaction with paraldehyde and pyridinium salts at room temperature, but it does not react with cycloalkyls or pyridinium salts at elevated temperatures.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Carbamothioyl-N-phenylacetamide is a basic compound that reacts with sodium hydroxide to form the corresponding amide. It is used in the synthesis of other compounds, including xanthine and caffeine. 2-Carbamothioyl-N-phenylacetamide can be prepared by reacting phenylacetic acid with thiourea in the presence of ethanol, followed by hydrolysis with sodium hydroxide. The product can also be obtained by heating xanthine in aqueous solution with sodium hydroxide and ethanol. This reaction is shown in figure 1 below.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Isocyanoethylbenzene, also known as 2-IBAB, is an organic compound that contains a carbonyl group and two isocyanate groups. It is used as a catalyst in hydrosilylation reactions to synthesize polymers such as polyurethanes. The reaction between 2-isocyanoethylbenzene and copper complex produces an imine that reacts with phosphite to form quinoline derivatives. These quinoline derivatives are then reacted with carboxylates to form ruthenium complexes, which catalyze the polymerization of deionized water. The polymerization initiator for this process is typically an organic peroxide or azide.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Cyclopropyl-3-methylthiourea (1CMTU) is an inhibitor of glutamate dehydrogenase and has been shown to regulate the levels of glutamate in the brain. It is an effective treatment for a number of neurological disorders, such as epilepsy and Parkinson's disease. 1CMTU inhibits the activity of glutamic acid decarboxylase, which is responsible for converting glutamate into GABA. This drug also prevents neuronal death by inhibiting oxidative stress and regulating insulin sensitivity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2H,3H,6H-[1,4]Dioxino[2,3-F]indole-7-carboxylic acid is an indole that reacts with electrophiles such as chlorine and bromine to form chloro and bromo derivatives. These derivatives can be used to produce a wide variety of compounds. The reactivity of this chemical is determined by the presence of electron withdrawing groups on the ring. When these groups are present, the compound is more reactive. This reactivity can be seen in the reaction with sodium hydroxide, which produces an alkoxide ion when reacted with 2H,3H,6H-[1,4]Dioxino[2,3-F]indole-7-carboxylic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>