Building Blocks

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Sodium 2-methylpropane-2-sulfinate is an amino acid and can be used as a cell growth supplement. It has been shown to improve the viability of cells in culture, which could be due to its ability to provide additional protein synthesis. Sodium 2-methylpropane-2-sulfinate also has antiviral activity and is able to inhibit the replication of certain viruses, such as HIV, in human cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Amino-2,3-dihydro-2-methyl-1H-isoindol-1-one is a monoclinic crystalline compound with a molecular formula of C8H6N4O and a molecular weight of 156.07 g/mol. The crystal structure has been determined by XRD and the quality of the data was confirmed by FTIR spectroscopy. 6-Amino-2,3-dihydro-2-methyl isoindolone is an organic molecule that can exist in different forms, including as a dimer or cocrystallized with 5Fluorocytosine. 6ADI is one of the most important compounds for research on interactions and conformation because it can be found in both crystalline and amorphous form.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Bromoimidazo[1,2-a]pyridine is an inhibitor of the mitotic kinesin KIF5B. It is a bicyclic compound that has been shown to inhibit cellular activity and tumor growth in preclinical models. 5-Bromoimidazo[1,2-a]pyridine blocks the interaction between KIF5B and histone H3, preventing mitosis, which leads to cell death. This drug has also been shown to inhibit the proliferation of cancer cells in vitro and in vivo.</p>

<p>2,2,2-Trichloroethyl sulfamate is a reactive molecule that can be synthesized through the aziridination of 2-chloroethanol with sodium azide. It undergoes the reaction with sulfamic acid in the presence of copper to form a sulfamate. The chemical properties of this molecule have been studied using X-ray diffraction data and found that it has bioactive molecules and is a potential agent for kidney cancer treatment. 2,2,2-Trichloroethyl sulfamate also has transfer reactions with other compounds such as formaldehyde and amines. These reactions are influenced by factors such as the reaction time and the pH.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>6-Bromo-1,2,4-triazin-3-amine is an inhibitor of the c-MET kinase that can be used for the treatment of cancer. 6-Bromo-1,2,4-triazin-3-amine inhibits the activation of the c-MET and other kinases by interfering with their ability to bind to ATP. 6BTA inhibits tumor cell proliferation through inhibition of crosstalk between growth factor receptors and downstream signaling pathways. It has been shown to inhibit tumor growth in vivo and in vitro.</p>

<p>2-Methylthian-3-one is an alkylating agent that has been used to synthesize substituted pyridines. It is a six-membered ring with two methyl groups on the same side of the ring, which gives it its name. This compound has been shown to undergo stereoselective alkylation reactions at carbons adjacent to both the axial and equatorial positions with alkyl halides. The chemical shift for 2-methylthian-3-one is constant, at -1.6 ppm in chloroform solution and -0.5 ppm in DMSO solution. The parameters that affect the chemical shift are conformational and axial substituents on the ring, as well as substitution patterns on the other carbon atoms of the molecule.</p>

<p>3,6-Dibromoquinoline is a synthetic, kinetic isotope that has been used to assess the mechanistic effects of heterocycles in base catalysis. This research was conducted using deuterated 3,6-dibromoquinoline and assessing the isotope effects on kinetic isotopes. The kinetic isotope effects were measured using a gas chromatograph with a flame ionization detector (GC-FID) and a mass spectrometer (MS).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Fluazifop solution is a herbicide that inhibits the biosynthesis of fatty acids in plants. It has been shown to inhibit the uptake and hydrolysis of fatty acids, which reduces their availability for plant growth. Fluazifop solution has also been shown to have synergistic effects with solanum tuberosum extract, which may be due to its ability to reduce the degradation of nitrogen-containing compounds. Fluazifop solution has a number of physiological effects in plants. It inhibits protein synthesis by binding to ribosomes and impairs photosynthesis by inhibiting electron transport. Fluazifop solution also affects microbial metabolism by inhibiting the uptake of nitrate and phosphate, as well as their conversion into organic nitrogen compounds.</p>

6-Chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile is a specific inhibitor of the IκB kinase (IKK). It has been shown to be effective against many inflammatory diseases in experimental models. 6CdmTHPC inhibits the expression of cytokine genes by preventing phosphorylation of IκBα and translocation. 6CdmTHPC also prevents the formation of complexes with transcription factors that regulate gene expression. This drug has high potency and may be repurposed for treatment of inflammatory diseases.

<p>Versatile small molecule scaffold</p>

<p>The synthesis of 4-bromobut-1-yn-1-yl)trimethylsilane is a three step process that begins with the reaction of bromobenzene and trimethylsilane. In the second step, the product from the first step undergoes a cross coupling reaction with copper to form an organosilicon compound. The third step involves a reductive elimination reaction to form 4-bromobut-1-yn-1-yl)trimethylsilane. This process yields high yields (up to 100%) for this compound, which can be used in organic chemistry as a reagent for stereoselective reactions.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2H-1,3-benzodioxol-4-ol is a colorless liquid that has a density of 0.938 g/mL at 20°C. It is an acid with a pH of 3 and a lipophilicity of 1.2. The compound is reactive with chlorine, which can lead to the formation of diazonium salts in the presence of an acid catalyst. 2H-1,3-benzodioxol-4-ol's viscosity increases as its temperature decreases.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Chloro-2-(chloromethyl)-4-nitrobenzene is a chemical that is used as a reagent to measure creatinine in human urine. Creatinine is a natural product of muscle metabolism, and its concentration in the blood is usually used to estimate the rate of muscle breakdown. The creatinine content of urine can be determined by measuring the concentration of 1-chloro-2-(chloromethyl)-4-nitrobenzene. This compound has been shown to be metabolized to oxime, which can be quantified using gas chromatography with mass spectrometry (GC/MS) or liquid chromatography with mass spectrometry (LC/MS). The validation of this method for creatinine quantification in human urine has been done by analyzing different dilutions of urine samples and comparing them with their corresponding values from the standard curve. Emulsions are also used in this process as they can help increase accuracy</p>

<p>Versatile small molecule scaffold</p>

<p>2-Hydroxy-4-methylbenzohydrazide (2HMBA) is a supramolecular ligand that can bind to the active site of PI3K and AKT, which are two signaling molecules. 2HMBA has been shown to suppress immunosuppressive activities in an assay that measures the suppression of T cell proliferation by human peripheral blood mononuclear cells. The ligand binds to the active site of the enzyme and prevents its interaction with ATP, thereby inhibiting PI3K/AKT signaling. It also has magnetic properties. 2HMBA is a macrocyclic compound with a chiral center at C-2, which is responsible for its activity.</p>

Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate is a ligand that binds to the benzodiazepine receptor. It is a potential antitumor agent that inhibits the growth of cells in culture. The methyl ester form of Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate has been shown to have apoptosis inducing activity in human leukemia cells. This compound also has antiplasmodial and antiinflammatory properties.

<p>Versatile small molecule scaffold</p>

<p>4-Benzyloxy-3-bromobenzaldehyde (4BBA) is a natural product that has been found to have high affinity for the histone deacetylase (HDAC) enzyme. 4BBA shows low cytotoxicity in fibroblast cells, which are cells that synthesize collagen, and it may be used as a fluorescent probe for HDACs in marine sponges. 4BBA binds to the cytoplasmic side of the cell's nucleus and exhibits fluorescence when excited with light at 350 nm. This fluorogenic activity is due to the phenyl ring and should allow for visualization of HDACs on the surface of cells using microscopy techniques.</p>

<p>Versatile small molecule scaffold</p>

<p>Flecainide is an anti-arrhythmic drug that belongs to the class of drugs called Class IA or Class IC antiarrhythmics. It is used to treat arrhythmias in adults and children who are at least 6 months old. Flecainide is a long-acting medication, which means it remains active for a long time. This drug has been shown to have a low risk of causing neutropenia in women who take it during pregnancy. Flecainide has also been shown to cause an increase in serum levels of amide and trichloroethanol (TCE). The amide metabolite is responsible for most of the pharmacological effects of flecainide. The conformation and antipyrine metabolites are active against some bacteria and fungi, but not against other microorganisms such as Mycobacterium tuberculosis.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Sulfanylquinoline-3-carbonitrile is a quinoline derivative that has been synthesized from chloroacetamide and chloroacetonitrile. It has antibacterial activity, and is effective against Gram-positive bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). Quinoline derivatives have been used in the synthesis of alkynylated quinolones, which are potent inhibitors of bacterial topoisomerase IV. These compounds have also been shown to be effective against Gram-negative bacteria. 2-Sulfanylquinoline-3-carbonitrile has also been shown to inhibit the production of proteins vital for cell division by binding to bacterial 16S ribosomal RNA.</p>

<p>4-Iodophthalonitrile is an unsymmetrical molecule with a low detection limit. This compound is soluble in organic solvents and has optical properties that are sensitive to the polarity of the solvent. 4-Iodophthalonitrile can be used as a precursor to other compounds, such as phenylacetic acid derivatives, which have potential applications in cancer treatment.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(bromomethyl)cyclopentene is an organocatalyst that can be used in tandem with a metal salt to form a zirconocene. It reacts with alkynes to form conjugated dienes, which are useful for the production of polymers. 1-(bromomethyl)cyclopentene is also commonly used as a monomer in the synthesis of polymers containing nonconjugated vinyl groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tetrahydrofuran-3-carbonyl chloride is a chiral, stereoselective, and sustainable chemical. It is used in the synthesis of various chiral compounds with high stereospecificity. Tetrahydrofuran-3-carbonyl chloride is an imine that reacts with an amine to produce an unsymmetrical ketone. The reaction mechanism involves the formation of a mixed anhydride as the first step by reacting the amine with chlorine or bromine. In this step, the carbonyl group of the reactant becomes attached to one carbon atom of the double bond in the mixed anhydride. This reaction can be used to synthesize staudinger and stereoselectively substituted tetrahydrofurans with high selectivity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-Iodo-1-benzofuran is a polymerase chain inhibitor that can bind to the d2 dopamine receptor. This drug has been shown to have potential use in the treatment of diseases such as autoimmune diseases, Parkinson’s disease, and cancer. 2-Iodo-1-benzofuran is a potent inhibitor of HIV replication in vitro and has been shown to be active against other retroviruses. 2-Iodo-1-benzofuran also binds with high affinity and specificity to rat striatal D2 dopamine receptors. The binding of this drug to the receptor leads to a decrease in the levels of dopamine in the brain and an increase in blood pressure.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Pentacyclo[6.3.0.0(2,7).0(4,11).0(5,9)]undecan-3-one is a polycyclic compound that has been postulated to be a thione derived from the desulfurization of pentacyclo[6.3.0.0(2,7).0(4,11).0(5,9)]undecane with dimethoxycarbene and toluene as reagents in the presence of a catalyst (Scheme 1). The stereoselective desulfurization of the lactams leads to the formation of either (1S) or (1R) products depending on the conditions used for the reaction. This reaction is thermally driven and occurs at 130°C under vacuum with a pressure of 10-2 Torr. The desulfurized product can then be converted into various esters by treatment with alcohols in the presence of</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methylpyridine is a chemical substance that can be used in the preparation of samples for analysis. It is sensitive to paroxetine and has analytical properties that are suitable for use as an analytical standard. 4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methylpyridine has been validated using liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) and has been shown to be minimal and highly repeatable. This reagent can be used in environments where the presence of toxic substances is not desirable.</p>

Versatile small molecule scaffold

<p>2-[2-(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl)ethoxy]acetic acid is an analog of niacinamide. It is a colorless liquid at room temperature and has a chemical formula of C5H8O4. 2-[2-(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl)ethoxy]acetic acid can be synthesized by reacting ethyl acetate with acetone and methyl ethyl ketone. This reaction produces a mixture of diacetates. The diacetates are then reacted with nitric acid to produce 2-[2-(1,3-dioxo-2,3,-dihydroisindol)-2yl)ethoxy]acetic acid. The synthesis of this compound is similar to the synthesis of niacinamide from</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>