Building Blocks

<p>2,5-Diiodobenzoic acid is a molecule that has been shown to have anti-cancer properties. It was found to inhibit the growth of malignant glioma cells in vitro and in vivo. The mechanism by which 2,5-diiodobenzoic acid inhibits the growth of these cells is not clear, but it may be due to its ability to change the permeability of the cell membrane or alter the function of proteins such as G proteins. This molecule has also been shown to bind with high affinity to cell nuclei, suggesting that it may be an effective imaging agent for use in diagnosis.</p>

<p>6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-one is a pyrrole with a planar conformation. It has hydrogen bonds to the carbonyl group and two benzenes. The molecule is centrosymmetric and has a dihedral angle of 180°. 6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-one crystallizes in the orthorhombic system. The unit cell dimensions are a=8.05 Å b=8.05 Å c=7.04 Å α=β=γ=90°</p>

<p>3,5-Dinitrobenzaldehyde is an experimental herbicide that has been shown to be effective in the control of weeds. 3,5-Dinitrobenzaldehyde is a protonated electrophilic species that reacts with a variety of electron-rich aromatic compounds by nucleophilic attack at the ortho position. The reaction with benzene, for example, yields phenyl trifluoride and benzenesulfonic acid. This molecule also reacts with chloride to form chlorobenzene and dinitrobenzene. 3,5-Dinitrobenzaldehyde has kinetic properties that are dependent on frequency and layeredness as well as kinetic and dihedral angles. It is also a catalytic reagent that undergoes rapid reaction at room temperature.</p>

<p>2-(4-Methylbenzenesulfonyl)cyclohexan-1-one is a peptide that is used as a research tool. It has been shown to act as an activator of ion channels and to bind to antibodies. 2-(4-Methylbenzenesulfonyl)cyclohexan-1-one can be used in the study of protein interactions and receptor ligand interactions. This product is available in both powder form and as an acetate salt.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

2-(1H-Tetrazol-1-yl)aniline is a nitroaniline that has been shown to form complexes with copper. It is an efficient method for the synthesis of 2-(1H-tetrazol-1-yl)anilines from nitrobenzenes, which are orthoformic and can be used as the starting material. 2-(1H-Tetrazol-1-yl)anilines can be used as a reagent in complex formation reactions, such as the nitration of orthoformates, or as a precursor to synthesize other compounds. The biological activity of 2-(1H-tetrazol-1-yl)aniline has been demonstrated by its ability to inhibit cyclocondensation and catalyze the hydrolysis of basic compounds. This compound also shows high efficiency in catalytic reactions with copper salts, which makes it reusable.

<p>Versatile small molecule scaffold</p>

<p>1-(4-Nitrophenyl)-1H-1,2,3,4-tetrazole is a nitroarene that can be used in the synthesis of disubstituted tetrazoles. It reacts with alcohols to form tetrazole compounds and with water to form anhydrides. The high reactivity of 1-(4-Nitrophenyl)-1H-1,2,3,4-tetrazole makes it suitable for use as a reactant in organic synthesis. The regioselectivity of this compound means that it can be used to synthesize only one product from two different starting materials. 1-(4-Nitrophenyl)-1H-1,2,3,4-tetrazole has been shown to react with arylacetonitriles to produce isoxazoles.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Chloroisothiazole is a chlorinating agent that reacts with active methylene groups of organic molecules to form vicinal dioxides. 3-Chloroisothiazole has been used in the synthesis of isoxazoles and alkynes, as well as for the chlorination of organic compounds. The reaction proceeds by nucleophilic attack of chlorine on the active methylene group to form a chloride ion, which then reacts with an alkyne or alkene to form an isoxazole or alkene respectively. 3-Chloroisothiazole has been found to be toxic, although it can be used in small amounts without significant side effects.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-cycloheptylacetate is a prophylactic drug that belongs to the group of pharmaceutical salts. It is used for the treatment of bipolar disorder and depression, but not for prophylactic purposes. Methyl 2-cycloheptylacetate encompasses gabapentin, which is used to treat epilepsy and neuropathic pain. The mechanism of action of methyl 2-cycloheptylacetate has not been elucidated yet, but it may act as an agonist at GABA receptors.</p>

<p>2-Cycloheptylacetamide is a trisubstituted compound that is structurally related to the cannabinoid receptor agonist WIN 55212-2. This drug has been shown to inhibit proteasome activity and to have anti-cancer effects in vitro. 2-Cycloheptylacetamide has also been shown to inhibit the activity of the enzyme monoamine oxidase, which may be associated with its antidepressant and anxiolytic activities. 2-Cycloheptylacetamide has been shown to prevent oxidative damage in neuronal cells, suggesting that it may be useful for the treatment of Alzheimer's disease and depression.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(Propan-2-yl)benzene-1,3-diamine is a mutagenic compound that belongs to the class of hydrolytic cleavage compounds. It has been shown to have mutagenic activity in Salmonella typhimurium and Escherichia coli. 4-(Propan-2-yl)benzene-1,3-diamine also has a high viscosity. This chemical is used as an intercept in tests for mutagens and carcinogens.br&gt;br&gt; <br>4-(Propan-2-yl)benzene-1,3-diamine hydrolyzes to form solvents such as isopropyl alcohol and water. The molecular weight of this compound is 162.17 g/mol.br&gt;br&gt; <br>4-(Propan-2-yl)benzene-1,3-diamine has not been shown to be carcin</p>

<p>3-(Hydroxymethyl)benzene-1,2-diol is an organic compound. The product is a colorless solid that has a molecular weight of 144.17 g/mol. 3-(Hydroxymethyl)benzene-1,2-diol reacts with metal surfaces and can be used in the synthesis of amides and amido groups. This product is reactive and acidic at high temperatures, but will not react with alcohols or amines. 3-(Hydroxymethyl)benzene-1,2-diol is also a reaction product from the synthesis of dopamine.</p>

<p>Ethanesulfonic acid, 1-methylethyl ester is a sealant that is used to coat the inside of an artery or vein. It has a low energy and is made up of formyl group, attenuating hydroxyl group, and chloride. This product also contains serine protease which can hydrolyze proteins in the plaque. The sealant contains functional groups such as cationic polymerization initiator and particle.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(6-Chloropyridazin-3-yl)-3-methyl-4,5-dihydro-1H-pyrazol-5-one (1) was found to be a potent inhibitor of β amyloid fibril formation and a lead compound for the treatment of Alzheimer's disease. The compound inhibits amyloid fibril formation by binding to the hydrophobic region in the core of the fibrils and preventing crosslinking. 1 also inhibits pancreatic β cell secretion, resulting in reduced production of insulin, which causes glucose intolerance. This drug has been shown to reduce glycemic levels in diabetic mice without causing hypoglycemia.</p>

<p>Versatile small molecule scaffold</p>

<p>Hexahydrophthalazin-1-one is a histamine H3 receptor antagonist. It has been shown to be a potent inhibitor of colon cancer cell growth in vitro, and it has been shown to inhibit the binding of histamine to the H3 receptor and interfere with the activation of this receptor. Hexahydrophthalazin-1-one also inhibits acidic ph histamine release from mast cells in vitro.</p>

<p>2,2-Dimethylheptanoic acid is a carboxylic acid that is also known as 2,2-dimethylpentanoic acid. It has the molecular formula of C8H16O2. This compound is an isomer of hexanoic acid and heptanoic acid. 2,2-Dimethylheptanoic acid is used in the production of lubricating oils and can be produced by the hydrogenation of fatty acids or glycerol. It also acts as an antioxidant, which protects polyunsaturated fats from oxidation.<br>2,2-Dimethylheptanoic acid has a boiling point of 150°C and a melting point of -62°C. It has a density of 0.891 g/cm3 at 20°C and a refractive index of 1.468 at 20°C. The colorless liquid can be found in the form of an oily liquid with a strong odor at room temperature.</p>

<p>3-Bicyclo[3.2.1]octanone is an organic compound that has a cyclohexane ring with a peroxide group. It is used as a synthon in the synthesis of other compounds. 3-Bicyclo[3.2.1]octanone can be synthesized by reacting α-pinene with carbon tetrachloride and cyclohexane in the presence of UV light and an oxidant, or by treating enolate with hydrogen peroxide catalysed with uv absorption to form a ketone and hydroperoxide. This product has been shown to possess UV absorption properties at 220 nm, which make it suitable for use in polymer films where it can absorb ultraviolet radiation and convert it into heat energy. The 3-bicyclo[3.2.1]octanone molecule is chiral, so only one stereoisomer will have these photochemical properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methanesulfonyl-3-methylphenol is a chromatographic and spectrometric reagent that reacts with sulfoxides to form sulfones. It is used in the analysis of pesticides, herbicides, and other organic chemicals. The reaction system consists of two components: the 4-methanesulfonyl-3-methylphenol reagent and the sulfoxide substrate. The linear range is from 0.1 to 100 micrograms per milliliter for 4-methanesulfonyl-3-methylphenol and from 1 to 500 micrograms per milliliter for sulfoxide. This chemical has been found to be resistant to hypersalinity, tissue acclimation, and oxidation products.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Ethylheptanoic acid is used in the analysis of sedimentation and viscosity. It was found to be a good antioxidant based on its ability to inhibit the oxidation of linoleic acid, which is an essential fatty acid. 3-Ethylheptanoic acid has also been shown to have chemopreventive properties in mice with skin cancer. This compound is thought to have anti-inflammatory properties because it inhibits the production of prostaglandins by inhibiting cyclooxygenase activity. Furthermore, 3-ethylheptanoic acid has been used as a chemical intermediate for synthesizing other compounds such as amines, alcohols, and phenolic compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>7-Diethylamino-4-hydroxy-chromen-2-one is a fluorescent chemical compound that belongs to the family of atypical fluorophores. It has a number of photophysical properties, including fluorescence and regression, which are characteristic of amines. 7-Diethylamino-4-hydroxy-chromen-2-one can be synthesized from diazonium salt and 4-hydroxycoumarin. This chemical compound has been used as a fluorescent probe for nucleophilic reactions in various types of organic molecules. The nature of this fluorophore is unknown, but it may be due to its ability to shift the wavelength of fluorescence by up to 400 nm.</p>

<p>5-Methyl-3-oxohexanenitrile is a dialkylamino compound that has been used as a reagent in organic chemistry. It is tautomeric and can exist as both an amide and an isoxazole. The pyridine ring of 5-methyl-3-oxohexanenitrile can be either substituted with a carbamate, nitro, or alkenyl group, depending on the substitution pattern. 5-Methyl-3-oxohexanenitrile reacts with dinitrophenyl to form an N–N bond, which is then cleaved by amines in order to generate the corresponding carbamate or amide. 5-Methyl-3-oxohexanenitrile also reacts with copper to form the corresponding nitro or alkenyl group.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

1,2-Dibromo-4-(bromomethyl)benzene is a brominated organic compound that has been shown to act as a potent agonist for the peroxisome proliferator-activated receptor delta (PPARδ). It has been shown to have structural and biological effects on PPARδ. This compound has been used as a template in the synthesis of many other compounds. 1,2-Dibromo-4-(bromomethyl)benzene is non-selective and bioavailable, which means it can be taken orally or applied topically.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-(5-Nitro-thiazol-2-yl)-benzamide is a noncompetitive inhibitor of the enzyme succinate dehydrogenase and is used as an molluscicide. It binds to the active site of the enzyme, which is located in the mitochondrial membrane, and prevents electron transfer from succinate to ubiquinone. This leads to a decrease in production of ATP, which is needed for cell growth and division. N-(5-Nitro-thiazol-2-yl)-benzamide has been shown to inhibit inflammation by inhibiting prostaglandin synthesis in mice. The drug also inhibits neutrophil infiltration into inflamed areas, which may be due to its effect on 5HT2A receptors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Cyanophenyl chloroformate is a macrocyclic compound that has been shown to have a potential use as an almqvist reagent. Almqvist reagents are nucleophilic compounds that can be used in organic synthesis as carbonylating agents, which are used to form esters and amides. 4-Cyanophenyl chloroformate is a chiral compound with the ability to form macrocycles, which are biomimetic structures. The conformational stepwise reaction of the macrocycle formation enables it to mimic natural processes.</p>

<p>Ethyl 2-(2-aminophenyl)acetate is a cytotoxic agent that binds to DNA and inhibits the synthesis of RNA and protein. It has been shown to inhibit the growth of murine leukemia cells in culture at concentrations between 0.3 and 3 mM, which are dependent on the concentration of benzyl substituents. Ethyl 2-(2-aminophenyl)acetate also exhibits dose-dependent cytotoxic activity against murine leukemia cells. The cytotoxic effects of this compound have been studied in vivo and in vitro using murine leukemia cells (WEHI-3).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(3-Bromopropyl)-4-chlorobenzene is an expedited source of chlorine that is used in the oxidation of aromatic compounds. The chlorination of 1-(3-bromopropyl)-4-chlorobenzene occurs with a yield of about 98% and has high selectivity for the chlorination product. In a photoredox process, this compound can be used as an oxidant to produce an intermediate that can then be used in the oxidative chlorination reactions. This compound has been shown to have bioactivity and is used as a science catalyst.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-[(Cyclopropylcarbonyl)amino]acetic acid is a carboxylic acid that is used as an oral drug for the treatment of cardiac and renal diseases. It has been shown to be effective in the treatment of angiotensin-dependent hypertension and congestive heart failure. The therapeutic effects may be due to its ability to inhibit angiotensin-converting enzyme (ACE) and block the conversion of angiotensin I to angiotensin II, which causes vasoconstriction and increased blood pressure. 2-[(Cyclopropylcarbonyl)amino]acetic acid also inhibits phosphodiesterase, which may lead to improved cardiac function.</p>

<p>2-Methyl-5-oxopyrrolidine-2-carboxylic acid (2MOP) is a levulinic acid derivative with a carboxylic acid group on the side chain. It can be synthesized from levulinic acid, which is produced from the hydrolysis of cellulose. 2MOP is used as a plasticizer and an intermediate in the synthesis of esters such as methyl acetate and ethyl acetate. 2MOP has been found to have good compatibility with polyvinyl chloride, polystyrene, and polyolefins. This compound has been used to produce plastics that are flexible, tough, and resistant to heat degradation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Acetamidobenzenesulfonamido)-3-methylbutanoic acid is a disordered molecule that has an isopropanol group at the 4th carbon. The benzene ring and methyl groups are in the 2nd and 3rd positions, respectively. The orientation of the isopropyl group determines how the molecule folds. This molecule has hydrogen bonds between its N-H and C=O groups, as well as intramolecular hydrogen bonds along with coplanar dihedral angles.<br>2-(4-Acetamidobenzenesulfonamido)-3-methylbutanoic acid is used for research purposes to study benzene rings, methyl groups, and acetamide orientations.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one is a synthetic drug that binds to the opioid receptor and is used as an analgesic. It has been shown to have a strong affinity for opioid receptors in the central nervous system and intestine. 2-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one has been found to have an uptake of 40% in the brain and intestine. This drug also has a high affinity for opioid receptors in the brain and intestinal tissue and acts as a full agonist on these sites. 2-Hydroxy-1,2,3,4-tetrahydronaphthalen-1-one also has been found to be effective in treating Alzheimer's disease. This drug can be administered orally or intravenously.</p>

<p>(2S)-2-Amino-N,4-dimethylpentanamide is an amide that is a metabolite of the amino acid l-tert-leucine. This drug has been shown to have bioactive properties and may be used in pharmaceutical preparations for the treatment of degenerative diseases. (2S)-2-Amino-N,4-dimethylpentanamide binds to cannabinoid receptors, which are found on the surface of cells. It also inhibits matrix metalloproteinase activity, leading to increased bone resorption and ulceration. The stereoisomers of this compound have different activities: 2R-(+)-(2S)-2-amino-N,4-dimethylpentanamide inhibits the production of inflammatory proteins and is used as a pharmaceutical preparation for the treatment of ulcers; 2S-(+)-(2S)-2-amino-N,4-dimethylpentanamide has</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(S)-1-phenyl-2-propyn-1-ol is a bicyclic compound that is used in the metathesis reaction. This chemical can undergo a metathesis reaction, where two different types of bonds are broken and two new ones are formed. (S)-1-Phenyl-2-propyn-1-ol can be used for the synthesis of polymers, pharmaceuticals, and agrochemicals.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(2-Formylphenoxy)propanoic acid is a carboxylic acid that is used in the synthesis of pharmaceuticals. The carboxylic acid group of 3-(2-Formylphenoxy)propanoic acid reacts with amines to form amides. It can also be reacted with alcohols to form esters. The propanoic acid group in this compound can undergo reactions that generate carboxylic acids, alcohols, and hydrocarbons. 3-(2-Formylphenoxy)propanoic acid has two carboxylic acid groups, one on each end of the molecule. These groups are positioned so they react with other molecules by donating their electrons to create new bonds. This conformation is called a dimer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Ethoxy-4-nitrophenol is a nitro compound that is used in the synthesis of dibenzofurans, polychlorinated biphenyls, and other organic compounds. It can be used to generate nitro groups in organic synthesis and has been shown to have high yields. 3-Ethoxy-4-nitrophenol is metabolized by the liver with a half life of approximately 10 hours and is excreted unchanged in the urine. This compound may cause adverse health effects at high doses due to its toxicity as a nitrosating agent, which may result in DNA damage or cancer.</p>

<p>Versatile small molecule scaffold</p>