Building Blocks

<p>Applications o-Iodohippuric Acid is used as a probe to measure renal function and clearance.<br>References Galinsky, R. et al.: Mech. Age. Dev., 56, 209 (1990);<br></p>

<p>Applications Asiatic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Asiatic Acid is a neuroprotectant and induces of apoptosis in HepG2 human hepatoma cells.<br>References Zhou, J. et al.: Jiang. Dax. Xueb. Yixueb., 19, 475 (2009); Hsu, Y.L. et al.: J. Pharmacol. Exp. Ther., 313, 333 (2005);<br></p>

<p>Stability Extremely Hygroscopic<br>Applications Labelled L-Arginine (A769500). An essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function).<br>References Miura, T., et al.: Anal. Biochem., 139, 432 (1984), Jones, et al.: Adv. Enzyme Regul., 9, 19 (1970), Borders, C.L., et al.: Protein. Sci., 3, 541 (1994),<br></p>

<p>Stability Hygroscopic<br>Applications An uremic toxin that acts as a potent endogenous agonist for the human aryl hydrocarbon receptor (AHR). Studies suggest that it is a sensitive and early biomarker of nephrotoxicity.<br>References Jennifer, C. et al.: Biochem., 49, 393 (2010); Zgoda-Pols, J.R. et al.: Toxicol. Appl. Pharmacol., 255, 48 (2011);<br></p>

<p>Stability Volatile<br>Applications SEC-BUTYL METHYL ETHER (cas# 6795-87-5) is a useful research chemical.<br></p>

<p>Applications 2-Ethyl-m-xylene, is one of the components thermocontact pyrolysis tars. It has been also found to be one of the volatile organic emissions from Motor Vehicles, that might have impact on ozone production.<br>References Koretskaya, N. A., Neftepererabotka i Neftekhimiya, 10, 44 (1978); Gentner, D. R., et al.: Environ. Sci. Tech., 47, 11837 (2013);<br></p>

<p>Applications A sulfonate ester as potential genotoxic impurity in drug substances. It may exert genotoxic effects in bacterial and mammalian cell systems.<br>References Eder, E., et al.: Xenobiotica, 12, 831 (1982), Li, W., et al.: J. Chromatogr., 1046, 297 (2004), Glowienke, S., et al.: Mutat. Res., 581, 23 (2005), Colon, I., et al.: J. Pharm. Biomed. Anal., 39, 477 (2005),<br></p>

<p>Stability Light Sensitive<br>Applications 4-Methoxyphenylhydrazine hydrochloride was used in the preparation of 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole. It was also used to synthesize diarylpyrazoles as possible cyclooxygenase 2 ((COX-2)) inhibitors.<br>References Iwakawa, T., et al.: Chem. Pharm. Bull., 48, 160 (2000); Penning, T., et al.: J. Med. Chem., 40, 1347 (1997)<br></p>

<p>Applications Bromocyclobutane<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6-Mercapto-1-hexanolcan be used as a chemical linker for anchoring biological molecules to gold surfaces.<br>References McKinlay, C. J. et al.: J. Am. Chem. Soc 138, 3510 (2016)<br></p>

<p>Applications 4-Imidazolecarboxaldehyde is a 4-formyl derivative of imidazole used in the preparation of C17,20-lyase inhibitor for the treatemnet of androgen-dependent prostate cancer. 4-Imidazolecarboxaldehyde is also used in the synthesis of other biologically active compounds such as antimalarial drugs.<br>References Kawakami, J. et al.: Org. Proc. Res. Dev., 11, 206 (2007); Kalkanidis, M. et al.: Biochem. Pharmacol., 63, 833 (2002);<br></p>

<p>Applications 4-Methylmorpholine is used in the synthesis of novel and selective TYK2 inhibitors, used in the treatment of inflammatory diseases. Also used in the preparation of cathespin K inhibitors which are highly selective.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liang, J. et al.: Eur. J. Med. Chem., 67, 175 (2013); Yuan, X. et al.: Org. Biomol. Chem., 11, 5847 (2013);<br></p>

<p>Stability Air Sensitive<br>Applications 2-Ethylhexanal, is an organic building block used in various chemical synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(N-Ethylanilino)ethanol can be used as a corrosion inhibitor. It can also be used as a reactant in the synthesis of a highly selective fluorescent probe for ALDH3A1-positive viable cells.<br>References Gupta, Meenakshi, et al.: Corrosao e Proteccao de Materiais, 31(1), 17-21 (2012);Yagishita, Atsushi, et al.: Bioconjugate Chem., 28(2), 302-306 (2017)<br></p>

<p>Applications N-Methylformamide is used in amidation or transamidation chemical reactions where formamide is insufficient.<br>References Rao, S. et al.: Org. Lett., 15, 1496 (2013); Xu, K. et al.: Chem. A. Eur. J., 18, 9793 (2012);<br></p>

<p>Applications Isobutyl Nitrite is used in the preparation of plasmoquin.<br>References Han, Qiang. et al., Faming Zhuanli Shenqing.(2020):<br></p>

<p>Applications Inosine-5'-monophosphate Disodium Salt Hydrate is used in Raman spectra of alkali and alkaline earth metal salts of inosine 5'-monophosphoric acid.<br>References Carmona, P., et al.: J. Raman Spectrosc., 27, 817 (1996)<br></p>

<p>Applications An inhibitor of NADPH oxidase (an enzyme responsible for reactive oxygen species production) and is useful in the treatment of various inflammatory diseases.<br>References Imnpellizzeri, D. et al.: Biochem. Pharmac., 81, 636 (2011); Genovese, T. et al: Brain Res., 1372;<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Catecholamines.<br>References Kopin, I.J., et al.: J. Biol. Chem., 236, 2109 (1961), Short, F.W., et al.: J. Med. Pharm. Chem., 5, 642 (1962)<br></p>

<p>Applications 3,6-Dichloro-2-hydroxybenzoic Acid Potassium Salt, is a hydroxybenzoic acid derivative and can be synthesized using a Kolbe-Schmitt carboxylation and acidification reaction of 2,5-dichlorophenol.<br>References Zhao, W-H., Song, G-Z.: Huagong Jishu Yu Kaifa, 44, 39-41 (2015)<br></p>

<p>Applications 4-Iodophenylhydrazine, HCl<br></p>

<p>Applications 9-Hydroxyfluorene is a wake promoting agent and is considered as the next generation anti-narcolepsy drug. It is also a potential environmental carcinogen.<br>References Dunn, D., et al.: Bioorg. Med. Chem. Lett., 22, 3751 (2012); Clark, J., et al.: Environ. Res., 117, 132 (2012); Li, F., et al.: Environ. Toxicol. Phar., 32, 373 (2011)<br></p>

<p>Applications 4-Iodo-N,N-dimethylaniline is a useful reactant for organic reactions and the synthesis of various compounds.<br>References Luo, X., et al.: Org. Lett., 20, 2997-3000 (2018); Hamasaka, G., et al.: Adv. Synth. Catal., 360, 1833-40 (2018);<br></p>

<p>Applications 2-Mercaptothiazoline is an antithyroid agent that strongly reduces thyroid hormone levels. 2-Mercaptothiazoline is also used as an intermediate in the preparation of pesticides and other biologically active compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thomes, J. et al.: Jap. J. Pharmacol., 58, 201 (1992); Buxeraud, J. et al.: Eur. J. Med. Chem., 20, 43 (1985); Cheng, J. et al.: Nongyao, 38, 12 (1999);<br></p>

<p>Applications 4-(3-HYDROXYPROP-1-EN-1-YL)-2-METHOXYPHENOL (cas# 458-35-5) is a useful research chemical.<br></p>

<p>Applications Ethyl fluoroacetate is an inhibitor of insect juvenile hormone biosynthesis. It also shows toxic effects against Vibrio fischeri.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Quistad, Gary B., et al.: J. of Agri. and Food Chem., 30(6), 1151-4 (1982);Dawson, D. A., et al.: Archives of Envir. Contam. and Tox., 66(2), 248-258 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications 1,6-Anhydrohexopyranoses have proven to be valuable synthons for the preparation of biologically important and structurally diverse products (e.g. rifamycin S, indanomycin, thromboxane B2, (+)-biotin, tetrodotoxin, quinone, and macrolide antibiotics) as well as for modified sugars.The chemical/physical/toxicological properties have not been thoroughly investigated. Since it is known to be a minor component of certain food materials it may be regarded as of relatively low toxicity.<br>References Fraser-Reid, B., et al. J. Am. Chem. Soc. 106, 731 (1984); Edwards, M.P., et al. J. Org. Chem. 49, 3503 (1984); Kelly, A.G., and Roberts, J.S. J. Chem. Soc., Chem. Commun. 228, (1980); Ogawa, T., et al. Carbohydr. Res. 57, C31 (1977); Isobe, M., et al. Tetrahedron Lett. 28, 6485 (1987); Fresnos, J.N. and Swenton, J.S. , J. Chem. Soc., Chem. Commun. 658, (1985); Kochetkov, N.K. et al., Tetrahedron Lett. 22, 4315, 4319 (1981); Georges, M. et al., Carbohydr. Res. 130, 115 (1984); Paulsen, et al., Chem. Ber. 114, 322 (1981).<br></p>

<p>Applications 4-(p-Iodophenyl)butyric Acid is a reactant involved in the synthesis of meta- and paracyclophanes containing unsaturated amino acids and intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones.<br>References Gibson, S., et al.: Tetrahedron, 60, 6945 (2004); Cui, D., et al.: Tetrahedron Lett., 44, 4007 (2003)<br></p>

<p>Applications Guanidinoacetic Acid is an important marker for renal failure, in kidney transplantation, and for the renal metabolic activity.<br>References Zugno, A., et al.: Neurochem. Res., 33, 1804 (2008), Debray, F., et al.: Neurol., 71, 44 (2008), da Silva, R., et al.: Am. J. Physiol., 296, E256 (2009),<br></p>

<p>Impurity Anastrozole Monoacid Impurity<br>Applications Anastrozole Mono Acid is an impurity of Anastrozole (A637435), an aromatase enzyme inhibitor and antineoplastic agent. Anastrozole Monoacid Impurity<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>

<p>Applications A nicotinic receptor agonist; brain rubidium efflux pharmacol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alkondon, M., et al.: J. Pharmacol. Exp. Ther., 271, 494 (1994); Wang, F., et al.: J. Biol. Chem., 271, 17656 (1996); Corringer, P., et al.: J. Neurosci., 18, 648 (1998);<br></p>

<p>Applications 1-Ethyl-3-hydroxypiperidine acts as a reagent for the preparation of new compounds of N,N-dimethyl-[3-(1-alkylpiperidy)]carbamates, as potential cholinesterase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mathison, I. W., et al.: J. Pharm. Sci., 62, 158 (1973)<br></p>

<p>Applications 4-Aminopiperidine is a useful reactant in organic synthesis.<br>References Park, Sun Jun, et al.: Bioorg. &amp; Med. Chem. Let., 27(18), 4399-4404 (2017);Le Manach, Claire, et al.: J. of Med. Chem., 59(21), 9890-9905 (2016)<br></p>

<p>Applications Methoxylamine is a methoxime derivative used as internal standard for Prostaglandin assays by gas chromatography-mass spectrometry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Herold, D.A. et al.: Prostaglandins, 33, 599 (1987);<br></p>

<p>Applications 3,5-Dimethoxyphenol is a phenol derivative as antinitrosating agent.<br>References Marletta, M., et al.: Chem. Res. Toxicol., 1, 249 (1988), Caulfield, J., et al.: J. Biol. Chem., 273, 12689 (1998), Wang, P., et al.: Chem. Rev., 102, 1091 (2002),<br></p>

<p>Applications 3-Hydroxyphenylacetic Acid (cas# 621-37-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Methylindole metabolite.<br>References Skordos, K., et al.: Chem. Res. Toxicol., 11, 741 (1998), Lanza, D., et al.: Drug Metab. Disposition, 29, 950 (2001), Hoenicke, K., et al.: J. Agric. Food Chem., 50, 4303 (2002),<br></p>

<p>Applications Nicosulfuron intermediate.<br></p>