Building Blocks

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-cyano-3-methylpyridine-2-carboxylic acid is a medicinal drug used to treat chronic diseases. It belongs to the group of p-glycoprotein (Pgp) inhibitors, which are trifluoromethylated compounds that are effluxed by Pgp from cells. 5-cyano-3-methylpyridine-2-carboxylic acid has been shown to inhibit BACE1, an enzyme responsible for the production of amyloid beta, which can lead to Alzheimer's disease. This compound also inhibits neural cell growth and nervous system activity in rats. The trifluoromethyl group in this molecule is important for optimization as it increases the affinity for binding with proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-3-oxobutanal is a reactive chemical intermediate which is used as a reagent in organic synthesis. It can be used to synthesize amines, amides, or imines. 2-Bromo-3-oxobutanal is also used as an industrial solvent and as an intermediate in the production of pharmaceuticals. This compound has been shown to react with DNA and RNA, altering their conformation and inducing conformational changes.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-tert-Butyl-1-methyl-2-pyrazolin-5-one is an electrophilic compound with a variety of use in the medical field. The compound has been used in research as a potential therapeutic for Alzheimer's disease, cancer, and other conditions. 3-tert-Butyl-1-methyl-2-pyrazolin-5-one has also been used to treat skin diseases such as psoriasis. It is typically administered topically or orally.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(2S)-2-Amino-N,3-dimethylbutanamide is a trifunctional molecule with a carbocycle that belongs to the class of chemical substances. It has been shown to be an inhibitor of human serum enzymes and it can also inhibit the production of human immunodeficiency virus (HIV). It binds to the receptor molecule and prevents HIV from binding to CD4 cells. The toxicological studies for this compound have been performed in cell culture and in animals. There are no reports on its effects on humans. This compound is not metabolized in vivo, but it is rapidly hydrolyzed by esterases in vitro, forming ethyl esters.</p>

<p>Versatile small molecule scaffold</p>

<p>5,7-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine is an aromatic heterocyclic compound. It can be prepared by the palladium-catalyzed coupling of aryl bromides with 5,7-dimethylpyrazolo[1,5-a]pyrimidines. The yield and synthesis conditions are dependent on the type of aryl bromide used in the reaction. This process has been shown to be a useful methodology for the synthesis of various heterocyclic compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Oxa-spiro[4.5]decan-8-one is a pentafluoroethyl derivative of an odorant that has been used as a blood substitute, and it has been shown to be insoluble in solvents. 1-Oxa-spiro[4.5]decan-8-one has a strong odor and is not soluble in water or common organic solvents. It can be found in the blood of mammals, but not humans.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(tert-Butyldimethylsilyloxy)butanal is a molecule that has been shown to have anticancer activity. It is structurally related to paclitaxel and epothilones, which are both derived from the cyclopentenone family of compounds. 4-(tert-Butyldimethylsilyloxy)butanal was found to be effective against a number of cancer cell lines, including leukemias, lymphomas, and breast cancers. The anticancer activity of 4-(tert-Butyldimethylsilyloxy)butanal is due to its ability to stabilize the enolate form of the enzyme alkylation, leading to inhibition of protein synthesis in cancer cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Hydroxymethyloxan-4-ol is a synthetic chemical that is used as a catalyst in the synthesis of citric acid. It is also used to catalyze the hydrogen peroxide oxidation of hydroxylated compounds and to produce citric acid from sugars. 4-Hydroxymethyloxan-4-ol is an acidic compound and can react with metals such as sodium, calcium, and magnesium to form metal oxides. This chemical has been shown to be a good inhibitor of peroxide formation in catalases.</p>