Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 5-acetyl-1H-pyrrole-2-carboxylate is a pyrrole-2-carboxylic acid that can be synthesized by the reaction of carbon tetrachloride and aliphatic alcohols. It is an experimental compound with a rate constant of 10.5 x 10^5 M^(-1) s^(-1). The synthesis of methyl 5-acetyl-1H-pyrrole-2-carboxylate can also be accomplished by the reaction of acetaldehyde, acetic anhydride, and formic acid. The compound has been studied for use as a catalyst for the conversion of esters and alcohols to aliphatic compounds. This process is catalyzed by methyl 5-acetylpyrrolecarboxylate in the presence of palladium on charcoal or platinum on coal.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Benzyl (2-((2-amino-4-methoxyphenyl)(phenyl)amino)-2-oxoethyl)carbamate (BZQA) is a nonselective, centrally acting acetylcholine receptor agonist. BZQA is a cholinergic agent that has been shown to have medicinal effects on cognition and the forebrain. It binds to the orthosteric site of acetylcholine receptors in the central nervous system, which is responsible for mediating the effects of acetylcholine. The pharmacokinetic properties of BZQA have been determined using a rat model, and it has been shown that this drug has low toxicity and high brain penetration.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Methoxycarbonyl)-5-methylbenzoic acid is a potent inhibitor of the enzyme xanthine oxidoreductase. It has been shown to inhibit the production of uric acid in cell-based assays, and also inhibits the enzyme xanthine dehydrogenase, which catalyzes the conversion of hypoxanthine to xanthine. 3-(Methoxycarbonyl)-5-methylbenzoic acid is a low nanomolar inhibitor of the enzyme xanthine oxidoreductase and is selective for this target over other enzymes such as cytochrome P450. 3-(Methoxycarbonyl)-5-methylbenzoic acid has an isostere group that binds to a subpocket on the enzyme and blocks access to substrate. The molecular weight of 3-(methoxycarbonyl)-5-methylbenzoic acid makes it suitable for analysis by X-ray crystallography.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Hexylhydroxylamine hydrochloride is a metal chelator that is used to bind heavy metals in the gastrointestinal tract. It is taken as a pill, and then binds to heavy metals such as lead, mercury, and arsenic. This prevents absorption of these toxic substances into the body. N-Hexylhydroxylamine hydrochloride has been shown to be most effective when it is given at high doses (2-3 grams) and causes less side effects than other chelators. One of the side effects of N-Hexylhydroxylamine hydrochloride is an increased risk for asphyxiation due to the increased concentration of gases in the lungs. The drug also has an effect on reticulatum pigment cells in the foregut, which can cause ulcers or cancerous growths if too much hexylhydroxylamine hydrochloride accumulates there.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tert-Butyl 3-iodopropylcarbamate is a monomer that possesses reactive chemical groups, such as carbonyl and iodide. It is used in the synthesis of polyamides and other molecules containing pyrrole rings. Tert-Butyl 3-iodopropylcarbamate is also used to synthesize oligonucleotides by coupling reactive groups on the nucleotide phosphoramidite monomers. This coupling reaction can be done with imidazole or tripyrrole nucleophiles. Tert-Butyl 3-iodopropylcarbamate can also be used to form heterodimeric complexes with cysteine. The tert-butyl group of tert-Butyl 3-iodopropylcarbamate is a sequence that may be removed by hydrolysis or reductive amination.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>