Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Allyl-4,5-dimethoxyphenol is a pheromone that binds to the olfactory receptor of Diptera. It is also present in the fruit of Eugenia sp. (Myrtaceae). The binding of 2-allyl-4,5-dimethoxyphenol to the olfactory receptor of Diptera has been shown in vivo and in vitro. Spectrometric analyses have revealed significant cytotoxicity for this molecule against breast cancer cells. This molecule may be transformed by β-caryophyllene and eugenol into bioactive molecules with cytotoxic, antioxidant, or antiinflammatory activities.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,1,1-Trichloro-4-ethoxy-but-3-en-2-one is a chemical compound that is used as a solvent and as a reagent in organic synthesis. It has been used to prepare pyrazole derivatives with regiospecific substitution at the alpha position. 1,1,1-Trichloro-4-ethoxy-but-3-en-2-one can also be used to produce enamines and vinyl ethers by reacting with pyrrole or carbonyl groups. This chemical is an excellent catalyst for reactions involving heterocycles such as sulfates and isomeric chlorides. 1,1,1-Trichloro4ethoxybut3en2one reacts with diethyl ether in the presence of a base to form ethyl chloride.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl (2E)-3-cyclopropylprop-2-enoate is a chiral compound. It can be synthesized from the corresponding chiral propionate by a cross-coupling reaction with cyclopropanes and triflates. The product is a racemic mixture of two diastereomers, an E and Z isomer, which can be separated using chromatography or crystallization. This compound has been used in the synthesis of natural compounds such as alkenes and esters. Methyl (2E)-3-cyclopropylprop-2-enoate can also be synthesized through the use of sodium borohydride to reduce acrylate or catalytic hydrogenation to reduce esters.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Pyrazolo[1,5-a]pyridin-2(1H)-one is a natural product that is found in plants and fungi. It has been shown to have anticancer activity by inhibiting the proliferation of cancer cells. Pyrazolo[1,5-a]pyridin-2(1H)-one may also act as a backup for dehydrogenase enzymes such as uridine 5'-diphospho-glucose dehydrogenase (UDPGDH) that are involved in the biosynthesis of nucleotides such as uridine triphosphate (UTP). Pyrazolo[1,5-a]pyridin-2(1H)-one inhibits mitochondrial membrane potential and cell proliferation in leukemia cells. The inhibition of mitochondrial membrane potential may be due to its ability to inhibit the enzyme electron transport chain complex I.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Bromo-4-(trifluorovinyloxy)benzene is a polyether that can be used to synthesize fluorescent polymers. The vinylene group in 1-bromo-4-(trifluorovinyloxy)benzene has shown to act as a nucleophile and yield polymerized products. This compound is insoluble in organic solvents, which makes it difficult to isolate yields. It has been experimentally shown that the anomeric carbon in this compound can be converted into the alpha form by treatment with potassium bis(trimethylsilyl)amide and then subjected to Wittig reaction.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Oxaspiro[4.4]nonan-6-one is a geometric isomer of the bicyclic compound 1,3,5-trioxaspiro[4.4]nonane. It has been synthesized by reacting 3-methylcyclohexanone with nitroethane in the presence of sodium ethoxide and potassium hydroxide. The substituents on the ring have been found to have an effect on the selectivity of 1-oxaspiro[4.4]nonan-6-one. For example, steric effects are more significant in this compound than in other six-membered rings with substituents that are not axial or equatorial. In addition, 1-oxaspiro[4.4]nonan-6-one has been shown to be a stronger diastereoselective agent than other six membered ring compounds with substituents that are not axial or equatorial due to</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>