Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Diethylamino)-2,2-dimethyl-propan-1-ol is a psychoactive substance that belongs to the group of phenethylamines. It is structurally related to the precursor molecule 2,5-dihydroxyphenethylamine (or dopamine). 3-(Diethylamino)-2,2-dimethyl-propan-1-ol has been shown to inhibit cytochrome P450 2C19 and metabolize into glucuronidated metabolites through CYP3A4 and other isoforms. This metabolite is excreted in human urine as a result of its metabolism by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl N-(3-methylphenyl)carbamate is a methylating agent that can be used to modify the epigenome. It is an inhibitor of histone lysine demethylases, which are enzymes that remove methyl groups from the amino acid lysine on histones. Methyl N-(3-methylphenyl)carbamate can also inhibit DNA replication and actin filament formation. This drug has been shown to have a clastogenic effect in mammalian cells and is also an inhibitor of effector proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one is a chemical compound containing an iodide group and a nitrogen atom. Iodides can be formed by the iodocyclization of ethyl acetoacetate with ethyl iodide. The resulting 5-ethyl-6-methylpyrimidinecarboxylic acid can be converted to the desired product by treatment with potassium hydroxide in ethanol.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(Mercaptomethyl)benzoic acid is a thiosemicarbazide derivative that has been used as a photosensitizer in photodynamic therapy. This compound has the ability to bind to selenide ions, which are electron acceptors, and is converted to its reactive form by light. 4-(Mercaptomethyl)benzoic acid may be used for the treatment of cancers that have been resistant to other treatments. The compound also shows potential for use in diagnosing or treating other conditions such as carboxylate ligand transfer reactions and cadmium toxicity. The diameter of this drug is around 2 nm.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>3-Methylnaphthalene-2-carboxylic acid is a dicarboxylic acid that can be found in the environment. It has been isolated from Australian soil samples and is produced by some bacterial strains. 3-Methylnaphthalene-2-carboxylic acid has antimicrobial activity, which may be due to its ability to inhibit microbial growth by inhibiting protein synthesis.</p>

<p>1-(Aminomethyl)naphthalene hydrochloride (1-AMN) is an organocatalytic oxidant that is used to oxidize quaternary ammonium salts and quinazolinones. 1-AMN is a white crystalline solid that can be stored at room temperature. It has been shown to have the ability to react with anisidine, amines, and alcohols to produce aniline, nitrosobenzene, and hydroxylamine, respectively. This product also has a functional group which is capable of reacting with chlorides or diazonium ions. The use of this product in biochemistry has been shown in the immobilization of biomolecules such as DNA and RNA.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Quinolin-2-yl)propanoic acid is a quinoline derivative that is used to treat inflammatory diseases. It is thought to have an anti-inflammatory effect by inhibiting the production of the fatty acid arachidonic acid, which is then converted into prostaglandins and leukotrienes. 3-(Quinolin-2-yl)propanoic acid inhibits cellular signaling by binding to specific protein receptors. This drug binds to the fatty acids in cell membranes, which leads to the inhibition of cellular growth factor signal transduction and signal detection. Research has shown that 3-(quinolin-2-yl)propanoic acid has a toxic effect on humans, as well as other animals, including rats and mice. The animal studies showed that this drug inhibited the growth of cancer cells in human colon tumors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>NSC 185058 is a potential cancer therapy that inhibits protein synthesis in the cell. It prevents cells from growing and dividing by inhibiting their ability to synthesize proteins. NSC 185058 also induces apoptotic cell death, which is programmed cell death that occurs as a result of genetic or environmental stress. When cells undergo apoptosis, they are able to destroy themselves without releasing harmful substances into the surrounding area. NSC 185058 has been shown to induce autophagy and autophagy-related proteins in animal models. Autophagy is a process by which cells break down dysfunctional components to recycle nutrients and energy for future use. NSC 185058 has also been shown to inhibit tumor growth in mice with malignant brain tumors when used in combination with other therapies such as radiation and chemotherapy.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,4-Dibromo-2,5-dimethylthiophene is a diphosphinoethane that has been used as a catalyst for the thermal and photochemical activation of methyl groups. It has been shown to have a high reactivity with hexane and form fluorescent polymer films. 3,4-Dibromo-2,5-dimethylthiophene is structurally similar to other diphosphinoethanes that are used in phosphine devices and polymer films. The crystal structure of 3,4-dibromo-2,5-dimethylthiophene has been determined using X-ray crystallography. In this study it was found that the molecule can exist in two different structural isomers.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Ethylthiazol-2-amine is a chemical that yields, on hydrolysis, a mixture of 5-ethylthiazole and 2-aminoethanol. It can be prepared by the reaction of ethyl mercaptan with carbon tetrachloride in the presence of potassium hydroxide. The spectral data for this compound are given in Table 1. The reaction time for this synthesis is about 25 minutes and it is operational at temperatures from 0 to 100°C. This compound reacts with tetracycline, an antibiotic, to yield a yellow solid. It also reacts with solvents such as acetonitrile and amines to give a white precipitate.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Phenyl N-(1,3-thiazol-2-yl)carbamate is a crystal structure stabilizer. It is an oriented, two-dimensional molecule that contains two phenyl rings (-C6H5) connected to each other by a single bond and one thiazole ring (-N=C=S). The orientation of the molecule in space is stabilized by a dihedral angle of 60° between the two phenyl rings. This orientation causes the phenyl rings to point in opposite directions and prevents them from rotating around their axis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>tert-Butyl 2-methyl-3-oxobutanoate is a metabolite of tert-butyl acetate, which is an organic compound that has been used for the production of synthetic rubber and other chemicals. The biosynthesis of tert-butyl 2-methyl-3-oxobutanoate is dependent on the availability of a ketoaldehyde precursor. When tert-butyl acetate is incubated with aspergillus niger, the desired product can be obtained in high yield. Tertiary butyl 2 methyl 3 oxobutanoate can also be synthesized by deuteration of tertiary butyl alcohol with deuterium gas. The product can then be purified using gas chromatography/mass spectroscopy (GC/MS) and identified using nuclear magnetic resonance (NMR) analysis.</p>

<p>Ethyl ±-Bromo-²-phenylpropionate is a thiomorpholine that is used in organic reactions. It has been found to be an effective catalyst for the epoxidation of alkenes, as well as for the acylation of alcohols and amines.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(2-Bromoacetyl)-1H-isochromen-1-one is a heterocyclic compound that can be prepared using the following preparative method.</p>

<p>Versatile small molecule scaffold</p>

<p>1,4,5,6,7,7a-Hexahydro-inden-2-one is a cycloaddition product of two 1,4-dihydrobenzenes. It has been shown to undergo the pauson-khand reaction with diazomethane to produce a cyclopropane ring.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>