Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>1-Boc-4-(2-hydroxyethyl)piperazine is a modification of piperazine that has potent activity against amyloid plaques. It is a cyclase inhibitor and can be used to treat Alzheimer's disease. 1-Boc-4-(2-hydroxyethyl)piperazine inhibits the production of amyloid beta protein by interfering with the formation of its precursor, amyloid beta peptide. The compound binds to the active site of cyclases and prevents ATP from binding, inhibiting the synthesis of amyloid beta protein. 1-Boc-4-(2-hydroxyethyl)piperazine can also be used as a treatment for other diseases including Parkinson's disease, multiple sclerosis, and spinal cord injury.</p>

<p>1-(4-{2-[4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]diazen-1-yl}phenyl)-2,5-dihydro-1H-pyrrole - 2,5 - dione (PDL) is a covalent azobenzene that can be activated by light. PDL has a variety of optical and photochemical properties. PDL binds to ion channels and alters the permeability of cells to ions. It is able to bind to heteromeric ion channels containing different subunits as well as to cysteine residues. The PDL molecule can also be taken up by tissues through passive transport and its uptake is increased when it is activated by irradiation.</p>

Versatile small molecule scaffold

<p>2-Iodo-5-methoxybenzaldehyde (2IMB) is a synthetic compound that has been synthesized in the laboratory. It is an annulated product of 2-iodoethanol and 5-methoxybenzaldehyde. This product belongs to the family of tetradehydroquinones, which are natural products. The 2IMB molecule contains a skeleton with an intramolecular Diels–Alder reaction and amination reaction that can be used as a building block for other molecules.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Carbamoyl-3-nitrobenzoic acid (2CNB) is an antiviral drug that has been shown to inhibit the replication of a variety of viruses, including coxsackievirus B3 and human respiratory syncytial virus. 2CNB is a mesomeric compound that can be used as a sodium salt or in its unreactive form. The antiviral effects are due to the inhibition of viral protein synthesis by 2CNB. 2CNB binds to amino acids in proteins, blocking the formation of amide bonds, which are necessary for protein synthesis. The antiviral activity of 2CNB is due to its ability to inhibit betaines and betaine, which are important intermediates in RNA synthesis.</p>

<p>1-Bromo-5-iodonaphthalene is a photolytic reagent that can be used for the preparation of phenols. It is a strong nucleophilic brominating agent and reacts with electron-rich compounds such as phenols, amines, and alcohols to form corresponding bromides. 1-Bromo-5-iodonaphthalene can also react with electron deficient compounds such as aromatic hydrocarbons and nitrobenzenes to form radical species. The photolysis of 1-bromo-5-iodonaphthalene in aqueous solution produces naphthalenes. This reaction is dependent on the pH of the solution and irradiation time. The solubility of 1-bromo-5-iodonaphthalene in water decreases when the pH increases.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Cyclopropylmethylmethylamine hydrochloride (CPMMA) is an experimental drug that belongs to the class of medicaments. It is a selective cannabinoid receptor type 1 (CB1) agonist which has been shown to reduce infarct size in animal models of myocardial reperfusion injury. CPMMA also has angiogenic and anti-inflammatory properties, which may be due to its ability to decrease cholesterol levels and inhibit the production of vascular endothelial growth factor (VEGF). This agent has potential as a treatment for hypercholesterolemia, coronary artery disease, and other cardiovascular disorders.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>8-Chloro-3-methyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione is a fluorescent amine that can be used in spectroscopy to detect the presence of ammonia. This product has a molar extinction coefficient of 3600 M−1cm−1 at 280 nm and can be used as a pH indicator.</p>

<p>1,3-Bis(benzyloxy)propan-2-one is an efficient and stereoselective synthesis of epoxides. It is a chiral molecule that can be used in the synthesis of enantiomers. The reaction involves a nucleophile (such as an alcohol) and an electrophile (an epoxide). This reaction proceeds in two steps with the nucleophile attacking at the carbon atom adjacent to the carbonyl group. The first step is a nucleophilic addition to form a tetrahedral intermediate which collapses to give an intermediate with two new stereogenic centers. The second step is then a nucleophilic attack by water on one of these new stereogenic centers, leading to formation of the product and release of hydrogen gas. 1,3-Bis(benzyloxy)propan-2-one has been shown to be more efficient than other methods for synthesizing epoxides, such as using acid chlorides or ox</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tert-Butyl 8-bromooctanoate is a pseudopepetide that has an affinity for the cck-A receptor. It has also been shown to inhibit membrane phospholipase A2 and increase inositol phosphate levels. This pseudopepetide was found to have pharmacological effects on the central nervous system, such as sedation, and may be useful in the treatment of pain or anxiety. Tert-Butyl 8-bromooctanoate is a macrocyclic compound that can form conformational changes in membranes. These changes may lead to an increase in intracellular calcium ion concentrations and stimulate insulin secretion from pancreatic beta cells.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>4-Pyridin-4-ylphenol is a redox active compound that can undergo one-electron reduction. It has been shown to be an excellent electron donor and acceptor in the electrochemical studies. 4-(Pyridin-4-yl)phenol also has a biradical structure, which is responsible for its unpaired electrons and unpaired spectra. This compound can be used as an initiator of free radical reactions due to its high redox potentials. The electron transfer properties of this ligand have been studied using electrochemical techniques and it was found to be capable of initiating oxidation or reduction of other compounds.</p>

Methyl 8-aminooctanoate hydrochloride (MAO) is a drug that has been shown to have an optimal activity in the nanomolar range. MAO is a betulinic acid amide derivative and interacts with the transcriptase and RNA polymerase of HIV type 1. The immunodeficiency of MAO was tested in vitro on human T cells, which showed that it had no effect on the growth of these cells. This may be due to its inability to cross the cell membrane.