Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(Z)-1-Chloro-2,3,3,3-tetrafluoropropene is a chemical used in commercial solvents. It is a colorless gas with an odor similar to that of hexane. It has been shown to have cardiac effects in chronic exposure studies and it can also cause chronic oral toxicity in animals. Studies on the toxicology of (Z)-1-chloro-2,3,3,3-tetrafluoropropene have been conducted using fruit extract and protein synthesis assays. The results show that this compound may be useful for the treatment of cancer and other diseases caused by protein aggregation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Dimethoxymethyl)-1H-pyrazole is a natural product that is produced by the reaction of acetals with catalytic amounts of trifluoromethanesulfonic acid. This chemical is synthesised by reacting orthoformates and functional groups. 3-(Dimethoxymethyl)-1H-pyrazole is found in catalytic amounts in the synthesis of pyrazoles and cyclic compounds. The yield of 3-(dimethoxymethyl)-1H-pyrazole can be increased by adding an oxidant to the reaction mixture.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>This linker, 2-(Pyridin-2-yldisulfanyl)ethan-1-ol, forms a disulfide bond with thiol-containing molecules. It can be cleaved intracellularly in a reductive environment, allowing controlled payload release.</p>

<p>1-Benzenesulfonyl-piperidine-4-carboxylic acid ethyl ester is an inhibitor of acetylcholinesterase. It is a white solid that can be synthesized in two steps from commercially available starting materials. Inhibition of this enzyme leads to the accumulation of acetylcholine, which causes increased stimulation of nicotinic and muscarinic receptors. This drug has been shown to have IC50 values that are similar to those of the reference inhibitor donepezil. 1-Benzenesulfonyl-piperidine-4-carboxylic acid ethyl ester also interacts with sulfonyl chlorides, butyrylcholinesterase, and other proteins in a manner similar to donepezil. The molecular docking studies suggest that this compound binds competitively with the active site of acetylcholinesterase.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(R)-Tetrahydrofuran-3-amine is a nucleoside phosphorylase inhibitor that binds to the catalytic site of the enzyme, inhibiting the synthesis of purine nucleotides. This drug has been shown to be effective in treating atrial fibrillation. (R)-Tetrahydrofuran-3-amine has also been used as a lead compound for the development of analogues with improved inhibitory potency and selectivity for adenosine receptors. The synthetic scheme for this compound starts by reacting 1,4-dihydropurine with aldehyde and formaldehyde under acid conditions. The product is then condensed with 2,2-dimethylpropane-1,3-dione to yield an intermediate that is oxidized and reduced to produce the final product. This process can be carried out using high performance liquid chromatography (HPLC) methods.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>