Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(R)-Tetrahydrofuran-3-amine is a nucleoside phosphorylase inhibitor that binds to the catalytic site of the enzyme, inhibiting the synthesis of purine nucleotides. This drug has been shown to be effective in treating atrial fibrillation. (R)-Tetrahydrofuran-3-amine has also been used as a lead compound for the development of analogues with improved inhibitory potency and selectivity for adenosine receptors. The synthetic scheme for this compound starts by reacting 1,4-dihydropurine with aldehyde and formaldehyde under acid conditions. The product is then condensed with 2,2-dimethylpropane-1,3-dione to yield an intermediate that is oxidized and reduced to produce the final product. This process can be carried out using high performance liquid chromatography (HPLC) methods.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Segetalin A trifluoroacetic acid is a protein-based product, which is a derivative of a natural compound isolated from the seeds of the plant Vaccaria segetalis. This plant is traditionally recognized for its medicinal properties, and segetalin A represents one of the active proteins responsible for these biological effects.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Perfluorophenyl methanesulfonate is an organic solvent. It is a colorless liquid that is soluble in water and in most organic solvents. The chemical formula for perfluorophenyl methanesulfonate is C6F5OCH3SO3Cl. This compound has the structural formula of CH2=C(O)CH2-CF3SO3Cl. Perfluorophenyl methanesulfonate can be used as a formylating agent to convert alcohols, amines, or carboxylic acids into their corresponding formates, amides, or acid chlorides. It can also be used as an additive to petroleum products to increase the boiling point of hydrocarbons by adding a formyl group to the hydrocarbon chain. Other uses include as a divalent hydrocarbon in alkynyl groups and alkoxycarbonyl groups and as a skeleton for phosphoryl groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methyl-2-p-tolyl-propylamine (MPTP) is an aromatic compound that has been shown to have some biologic activity. MPTP was first synthesized in the lab of Dr. K.B. Sharpless and his team at Duke University in 1979, who were attempting to make an inhibitor for monoamine oxidase B (MAO-B). MAO-B is a type of enzyme that breaks down the neurotransmitter dopamine, which is involved in the regulation of movement and emotions. The synthesis of MPTP was abandoned when it was found that the compound was instead metabolized into a neurotoxin called 1-methyl-4-phenylpyridinium (MPP+), which caused Parkinson's disease in mice.<br>MPTP causes cell death by inhibiting mitochondrial complex I, which produces adenosine triphosphate (ATP) needed for cell function, leading to cell death through apoptosis or necrosis</p>