Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>(1S)-1-(4-Iodophenyl)ethan-1-ol is an electrophilic reagent that is used in the synthesis of imidazoles. It is generated by the chemoenzymatic, regioselective alkylation of a phenyl ring with a stannylated phenyl amine. This process can be performed using a variety of different reagents and solvents, including N-chloro-N-methylpyridinium tetrafluoroborate (NCMP). The regioselectivity of the reaction ensures that the desired product is generated in high yield.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Cyclopropylthiophene is a compound that can be synthesized by arylation of 3-cyclopropyl-thiophene with an aryl iodide in the presence of copper. The reaction can be catalyzed by diaryliodonium salts, and the selectivities are determined by the counterion. Cyclopropylthiophene is used as a model substrate for mechanistic studies on asymmetric catalysis. Cyclopropylthiophene can also be applied to the synthesis of nanoparticles for catalysis in organic reactions.

Versatile small molecule scaffold

<p>3-Methylpiperidine-2,6-dione is a dipeptide that is used to form an oral drug delivery system. It is encapsulated in silicone and has affinity for hydrogen peroxide. A heterostructure is created by sandwiching the 3-methylpiperidine-2,6-dione between two layers of acrylate. This creates a device that can be activated by light and will release the dipeptide when it reaches a specific pH level. The acrylates are dissolved in an oxocarboxylic acid, which also denatures the peptide to prevent proteolysis by enzymes in the stomach. Once it reaches the small intestine, the phthalimides are cleaved from the 3-methylpiperidine-2,6-dione, leaving behind an intact dipeptide.</p>

2-(Ethylsulfanyl)phenol is a hyphenated chemical compound that has been shown to be toxic to cells. It is a radical that can form in the body, and it has been found to have high potential for health risks. The reaction time for 2-(Ethylsulfanyl)phenol is an average of 130 seconds, which is much faster than most other chemicals. Kinetics for this compound are also rapid, with an average rate of 10-14 μmol/L per second. 2-(Ethylsulfanyl)phenol reacts with DNA at the scission site, which generates a free radical that damages the DNA strand and breaks it down into smaller fragments. This chemical has been shown to cause DNA damage at a rate of 0.1% per hour, which can lead to cell death and cancer development.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-methyl-3-oxo-3-phenylpropanoate is a zerovalent metallorganic compound. It is used as an intermediate in the synthesis of other compounds and has been found to be a good catalyst for the benzoylation of olefins. The compound is prepared by reacting an azide with a benzyl alcohol. This reaction proceeds via an initial hydrolysis of the azide to form a chloride, followed by substitution of the chloride with the alcohol to form the desired product. The catalytic mechanism is thought to involve magnesium ions, which are reduced to magnesium cations upon addition of chloride ions.<br>The compound has not been shown to produce any toxic effects in humans and can be safely handled without protective equipment.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-(1H-Imidazol-2-yl)aniline is an antimycobacterial agent that can be used concurrently with diethylamine. It has been shown to react with acetone and phenyl isocyanate to form a series of compounds, including 2-(1H-imidazol-2-yl)acetophenone, 2-(1H-imidazol-2-yl)-N,N'-dimethylformamide, and 2-(1H-imidazol-2-yl)-N,N'-diisopropylethane diamide. The substituents on the imidazole ring are reactive and can form aliphatic carbamates or isocyanates.</p>

<p>Versatile small molecule scaffold</p>

1-Phenylcyclopropan-1-ol is a reactive oxygen species (ROS) that can be used as an endogenous substrate for the cytochrome P450 enzymes. 1-Phenylcyclopropan-1-ol has been shown to activate NADPH cytochrome P450 reductase in human liver microsomes and rat liver microsomes. It is also known to inhibit the formation of azides from drugs such as diphosphine and polyclonal antibodies, and has been proposed to be an immunosuppressant drug. 1-Phenylcyclopropan-1-ol has been shown to inhibit the growth of cancer cells in vivo, which may be due to its ability to induce apoptosis. !-- -->

<p>Versatile small molecule scaffold</p>

<p>Azepane-2,4-dione is a reactive intermediate in the synthesis of quinolines. It can be synthesized by acid treatment of benzofuran, followed by condensation with piperidine and quinone, or by condensation of 2-aminoethanethiol with chloroacetyl chloride. Azepane-2,4-dione is not stable and spontaneously reacts with water to form an adduct. The compound can be converted to the corresponding quinoline through a two step process involving enamine formation and cyclization. This reaction is catalyzed by palladium on carbon or stannic chloride on alumina.</p>

Versatile small molecule scaffold

<p>4-Chloro-2,6-diphenylpyrimidine is a chemical compound that exhibits growth-regulating properties. It has been used as a solvent for the synthesis of other organic compounds. 4-Chloro-2,6-diphenylpyrimidine is a tautomeric compound with two different forms: the catechol and the ketone form. The catechol form is more stable than the ketone form and can be activated by light or heat to produce an excited state. This excited state can emit light in the visible region of the spectrum, which can be measured using fluorescence spectroscopy. 4-Chloro-2,6-diphenylpyrimidine also has high solubility in water and good transport properties. This chemical has been shown to have thermally activated rearrangements and amide cleavage reactions when heated or subjected to acid conditions.</p>

Versatile small molecule scaffold

Ethyl 7-methyloctanoate is a silicone that can be used as a nutrient or as an emulsifier in skin care products. It has high water retention capacity, and can be used to form lipid bilayers in liposomes. Ethyl 7-methyloctanoate has been shown to have antioxidant properties, which is due to its ability to scavenge free radicals and inhibit lipid peroxidation. This compound also has the ability to protect against UV radiation induced damage by absorbing UV light and converting it into heat.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold