Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Bromo-4-ethynyl-1-methoxybenzene is a potent inhibitor of adenosine kinase, an enzyme that catalyzes the phosphorylation of adenosine to make it active. This agent has been shown to inhibit the activity of other enzymes in the adenosine pathway, such as phosphodiesterases and nucleoside transport proteins. 2-Bromo-4-ethynyl-1-methoxybenzene is not a nucleoside and does not act by binding to DNA or RNA. It has been shown to be effective in vivo and in vitro against lymphomas, leukemia, and breast cancer cells.

5-Iodobenzene-1,3-dicarbaldehyde is a chemical compound with the molecular formula C6H5I. It is an electron acceptor that can be used in organic chemistry as a moiety to form transition metal complexes. 5-Iodobenzene-1,3-dicarbaldehyde can be detected by its red shift in the visible light spectrum and has been shown to exhibit antiferromagnetic coupling. The unpaired electron delocalizes over two carbons, which leads to hyperfine coupling between the two carbons. This results in a detectable shift in the wavelength of light absorbed or emitted by the molecule.

Versatile small molecule scaffold

Pyrido[3,4-b]pyrazin-5-amine is a crystalline solid with a solvate. It has been shown to inhibit the growth of bacteria by binding to the 50S ribosomal subunit. Pyrido[3,4-b]pyrazin-5-amine binds to the penicillin-binding proteins in the bacterial cell wall by competitive inhibition. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold