Building Blocks

2-(ethanesulfonyl)acetonitrile is an organic solvent that has a constant boiling point, high reactivity, and low toxicity. It can be used as an acid catalyst in fluorination reactions or to synthesize nitro groups. 2-(ethanesulfonyl)acetonitrile has a reactive functional group and hydrocarbon group that can be substituted with other substituents. The fluorine atom in this compound is replaced with a nitro group when it reacts with oxygen. 2-(ethanesulfonyl)acetonitrile is used in synthetic chemistry to create nitro compounds by the reaction of nitric oxide with the nitro-group on the aromatic ring.

Versatile small molecule scaffold

1-(4-Nitrophenyl)azepane is a potent fxa inhibitor. It inhibits the serine proteases, such as thrombin, and has been shown to have anticoagulant effects in animal models. 1-(4-Nitrophenyl)azepane interacts with the active site of serine protease and competes with the substrate for binding to coagulation proteins. This inhibition leads to a reduction in coagulation and an increase in bleeding time.

Versatile small molecule scaffold

3-Bromo-6-chloroquinoline is a cisplatin analogue that is used in the treatment of cancer. It has been shown to have cytotoxic effects against human T47D cells, an estrogen receptor positive cell line, by binding to DNA and interfering with DNA replication. 3-Bromo-6-chloroquinoline has also been shown to have significant cytotoxic activity against the Mcf-7 breast cancer cell line. It binds to the proximal region of the human cytochrome P450 1A2 enzyme and blocks its ability to metabolize drugs, which prevents the activation of certain anticancer agents. This drug also inhibits the synthesis of RNA and protein, leading to cancer cell death.

3-Vinylthiophene is a stabilizer that can be used in the production of polymers and copolymers. It is used in the Suzuki coupling reaction to form vinylidene-3-thiophene, which has been shown to be an effective surface modifier for mesoporous materials. 3-Vinylthiophene has low affinity for both organic ligands and metal ions, making it a reactive compound. The absorption spectroscopy of 3-vinylthiophene shows a strong peak at 290 nm and a weak peak at 320 nm. With a photoelectron spectroscopy, it was found to have an electron affinity of 2.5 eV with a reactive copolymerization with phenylethyl and selenophene being possible reactions.

2-Methyltetrahydrothiophen-3-one is an organic solvent that is found in the environment as a result of natural processes. It has been shown to inhibit bacterial growth and is used for the analysis of fatty acids. 2-Methyltetrahydrothiophen-3-one inhibits bacterial growth by inhibiting the synthesis of fatty acids, which are needed for cell membrane synthesis.

2-Hydrazinylpyrimidine-5-carbonitrile is an anticancer drug that inhibits cell proliferation by binding to transition metal ions. It has cytostatic activity and is used to treat cancer. 2-Hydrazinylpyrimidine-5-carbonitrile also has antibacterial properties and can be used to treat infections caused by staphylococcus. The drug inhibits bacterial growth by binding to the sulfhydryl groups of enzymes such as methionine adenosyltransferase and acylhydrazone synthase, which are involved in fatty acid synthesis. This inhibition leads to a decrease in the production of fatty acids, thereby leading to bacterial death. 2-Hydrazinylpyrimidine-5-carbonitrile has been shown to have antiplatelet effects and can be immobilized for in vitro anticancer activity studies.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Chloronaphthalen-2-amine is a high concentration, organic solvent that is soluble in water and stable. It has been shown to be a reductant, which is a substance that donates electrons to another reactant in a chemical reaction. 3-Chloronaphthalen-2-amine can be used as a solvent for underwater applications and may have the ability to reduce nitrogen gas into ammonia. The residue of 3-chloronaphthalen-2-amine can be removed by solvents such as chloroform or ether.

Versatile small molecule scaffold