Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Spiro[3.5]nonan-2-one is an intermediate in the synthesis of a number of analogues, including the anti-tuberculosis drugs ethambutol and isoniazid.</p>

<p>Methyl 4-Pyridinylacetate is a reactive compound that reacts with trifluoromethylthiolation. It also inhibits the aromatase enzyme and has been shown to react with benzoates to form stereoselective products. Methyl 4-Pyridinylacetate is an aromatic compound that can be used in the synthesis of anilines. It is synthesized from pyridine compounds, which are heterocycles, and methyl chloride. Methyl 4-Pyridinylacetate has not been shown to be reactive with sesbanine or unreactive to chiral compounds.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

5,6,7,8-Tetrahydronaphthalene-1-carbonitrile is a reactive chemical that has been used as a photochemical precursor to other organic molecules. It can be synthesized by the Birch reaction and the Robinson annulation. It reacts with acetonitrile in an acid-catalyzed reaction to form a biradical species that can undergo intramolecular cyclization to form tetralin or undergo intermolecular reactions with other molecules. The photophysical properties of 5,6,7,8-tetrahydronaphthalene-1-carbonitrile have been studied using fluorescence data. 5,6,7,8-Tetrahydronaphthalene-1-carbonitrile is also used as a substrate for quantum yields experiments.

O-Decylhydroxylamine is a chlorine-containing fatty acid that has been shown to inhibit serine proteases, nitro compounds, and ornithine decarboxylase. It also has amide and dialkylamino groups. O-Decylhydroxylamine is used as a cross-linking agent in the treatment of chronic bronchitis and has been found to be effective in reducing inflammation associated with prostate cancer cells. O-Decylhydroxylamine also inhibits insulin resistance in cells by preventing the release of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) or interleukin-6 (IL6).

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>N-Benzyl-N-methylacetamide is a cardiac stimulant and thermogenic that has been shown to increase the rate of metabolism in mammals. It is an electrophile that can be converted to a reactive form by perchlorates and other oxidizing agents. The resulting n-oxide reacts with amino acids, yielding iminium ions that react with amide bonds in proteins, altering their structure and function. N-Benzyl-N-methylacetamide has also been shown to have antioxidant properties in vivo studies on mice. It may also have carcinogenic effects due to its ability to induce oxidative stress and DNA damage.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Methyl 5-aminopentanoate hydrochloride is an amide that has a protonated methyl group. It is a colorless liquid with a boiling point of 173°C and a melting point of -7°C. The technique used to measure the affinity of this compound for benzyl esters is called titration. Methyl 5-aminopentanoate hydrochloride is also soluble in water, chloroform, and ether. The molecule has two methyl groups (CH3) and one carboxylic acid group (COOH). The physicochemical properties of this substance are determined by the size and charge of its atoms.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,5-Dichloro-N-(2-methyl-3-oxobutan-2-yl)benzamide (3,5DCMB) is a herbicide that inhibits photosynthesis in plants. It is metabolized to dichlorobenzene and hydrated to 3,5-dichlorobenzaldehyde. The metabolites are excreted through the urine or via the lungs. 3,5DCMB is also a xenobiotic with an ethynyl group and a methyl ketone group.</p>

Versatile small molecule scaffold

<p>Octahydro-1H-inden-1-one is an alkylation agent that has been used in the synthesis of triketones and ethyl diazoacetate. This compound is a synthetic intermediate that is used to produce organic compounds. It can be prepared by the kinetic reaction of ethyl diazoacetate with chloride or by the thermolysis of 1,3,5-triketone. Octahydro-1H-inden-1-one can also be synthesized from octahydrobenzofuran using a regiospecifically catalyzed reaction. The compound exists as two regiospecific isomers due to its double bond: cis and trans. The cis form has greater reactivity than the trans form because it has two electron withdrawing groups on the same side of the double bond and it can be hydrolyzed more easily than its trans isomer.<br>Octahydro-1H-ind</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>1-Bromo-3-methanesulfinylbenzene (1BrMS) is a chemoselective oxidant that can be used for the oxidation of sulfides and sulfoxides. 1BrMS has been shown to have an optimum pH of 9.5, and it has been shown to be catalytic in the presence of hydrogen peroxide. It also exhibits enantioselectivity and chemoselectivity as well as high regioselectivity. 1BrMS is stable under basic conditions, but breaks down under acidic conditions due to its reactive nature. The parameters of 1BrMS are not fully understood at this time, but it has been shown to be a powerful oxidant with potential applications in organic synthesis.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>2-(2-Propynyloxy)benzenecarbaldehyde (2-POBA) is a biomolecule that can be used as a fluorescence probe. It reacts with nucleophiles, such as pyridines and coumarins, to form radical species. 2-POBA has shown antibacterial activity against subtilis and other bacterial strains. The allyl group in 2-POBA is responsible for the antibacterial activity. 2-POBA also reacts with cyclic voltammetric and electrospray ionization techniques to produce an ion signal that is indicative of its presence in solution.</p>