Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 4-methanesulfonamidobenzoate is an enzyme inhibitor that binds to the hydroxyl group of the active site on enzymes, such as human protein kinase. The hydroxyl group of this compound interacts with the amide group of the enzyme, preventing it from carrying out its normal function. Methyl 4-methanesulfonamidobenzoate has been shown to inhibit a number of different enzyme isozymes, including 2-methylisocitrate dehydrogenase and cyclooxygenase 2. This drug also has selectivity for one conformation over another because it binds only to the human form of these enzymes, while not binding to other animal or microbial forms.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(3-Methoxyphenoxy)benzoic acid is a chemical compound that has dehydrating properties and can be used industrially as an organic solvent. It is a colorless, water-soluble liquid with an aprotic nature. 4-(3-Methoxyphenoxy)benzoic acid is also used to prepare other chemicals by hydrolysis, such as 3-methoxybenzoic acid and 3,4-dimethoxybenzoic acid.

4-Bromo-3-chlorosulfonylbenzoic acid (4BCSA) is a synthetic cannabinoid that has been modified to have increased affinity for the CB2 receptor. 4BCSA has been shown to produce analgesia in animal models of neuropathic and inflammatory pain. This drug also blocks the effects of endocannabinoids at the CB1 receptor, which may be useful for treating postoperative and chronic pain. In addition, 4BCSA has been shown to inhibit caspase activity in cells and increase levels of glutathione, which may have therapeutic benefits for diseases such as cancer.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,4,5-Trichlorothiazole (2,4,5-T) is a chlorinated organic acid that is used as an active substance in the manufacture of pesticides. 2,4,5-T has been shown to be toxic to plants and animals by inhibiting growth and causing damage to cells. It has been used as an herbicide for the control of weeds and grasses in crop fields. The chemical is also an algicide for the control of algae in lakes and rivers. 2,4,5-T can be applied as a foliar spray or soil drenching agent. This chemical can also be diluted with water or other substances before application.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Bromocyclohex-2-en-1-one is a reactive compound that belongs to the group of organometallic compounds. It is utilized in polyphosphoric acid production, where it reacts with hydrocarbons and alcohols to form esters or ethers. This compound may also be used as an intermediate in the preparation of Taxol, which is a drug used to treat cancer. 2-Bromocyclohex-2-en-1-one has shown enantioselective reactions with chloride ion and chiral trifluoroacetic acid, leading to the formation of enolate anion. The reaction mechanism for this process is still not fully understood.

Versatile small molecule scaffold

4-Methyl-3-quinolinamine is a compound that is synthesized by the diazotization of 4-methyl-3-nitroaniline and can be used as a synthetic intermediate. The ring system of this compound has not been determined.

N'-Hydroxyfuran-2-carboximidamide is an antibacterial agent that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. It is used to treat eye infections and is also used as an adjuvant in animal vaccines. N'-Hydroxyfuran-2-carboximidamide has been shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.

Versatile small molecule scaffold

Pyridazine-4-carboxaldehyde is a pyridine derivative that has been shown to have antiherpetic properties. It can be synthesized by reacting pyridazine with methyl iodide and anhydrous potassium carbonate. Pyridazine-4-carboxaldehyde is a potent inhibitor of human cytomegalovirus (HCMV) replication in cell culture, and its activity against the virus may be due to its ability to inhibit DNA synthesis and act as a cytotoxic agent. Pyridazine-4-carboxaldehyde has also been studied for its potential use in cancer treatment, with one study showing that it was able to inhibit tumor growth in mice.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Amino-2,4-dichlorobenzoic acid is a metabolite of malonate that inhibits the synthesis of fatty acids by inhibiting the activity of fatty acid synthetase. It has been shown to inhibit lipid accumulation in plants and may be used as an inhibitor in plant physiology experiments. 3-Amino-2,4-dichlorobenzoic acid can be applied to explants before or after treatment with test compounds to determine its inhibitory effect on fatty acid synthetase activity. 3-Amino-2,4-dichlorobenzoic acid is also a potent inhibitor of endogenous lipogenic enzymes.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold